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ChemicalBook >> CAS DataBase List >>8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one

8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one

8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one Structure
8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one structure
CAS No.
1352717-91-9
Chemical Name:
8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one
Synonyms
8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one;4(3H)-Quinazolinone, 8-bromo-6-fluoro-2-methyl-
CBNumber:
CB13065818
Molecular Formula:
C9H6BrFN2O
Molecular Weight:
257.06
MDL Number:
MFCD27996279
MOL File:
1352717-91-9.mol
MSDS File:
SDS
Last updated:2026-05-27 23:28:29
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8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one Properties

Boiling point 357.7±52.0 °C(Predicted)
Density 1.81±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 0.50±0.20(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933998090

8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC535071 8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one 95% 1352717-91-9 250mg $44 2026-06-04 Buy
Apolloscientific PC535071 8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one 95% 1352717-91-9 1g $158 2026-06-04 Buy
Matrix Scientific 296116 8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one 1352717-91-9 250.00mg $26 2026-05-19 Buy
Matrix Scientific 296116 8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one 1352717-91-9 1.00g $84 2026-05-19 Buy
Matrix Scientific 296116 8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one 1352717-91-9 5.00g $411 2026-05-19 Buy
Product number Packaging Price Buy
PC535071 250mg $44 Buy
PC535071 1g $158 Buy
296116 250.00mg $26 Buy
296116 1.00g $84 Buy
296116 5.00g $411 Buy

8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one Chemical Properties, Uses, Production

Synthesis

8-Bromo-6-fluoro-2-methyl-4H-benzo[d][1,3]oxazin-4-one

1352717-90-8

8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one

1352717-91-9

8-Bromo-6-fluoro-2-methyl-4H-benzo[d][1,3]oxazin-4-one (12,466 mg, 1.81 mmol) was used as a feedstock and suspended in 28% v/v aqueous ammonia solution (8 mL). The reaction mixture was stirred at reflux for 1.5 h at 100 °C. After completion of the reaction, the reaction mixture was concentrated. The resulting precipitate was collected by filtration, washed with distilled water (20 mL) and dried to constant weight to afford 8-bromo-6-fluoro-2-methylquinazolin-4(3H)-one (14,342 mg, 73.7% yield) as a pale white solid. The product could be used in subsequent reactions without further purification. The product was characterized by the following data: retention time (t R) = 2.40 min, purity = 100%; no ions detected by ESI+MS; 1H NMR (DMSO-d6) δ (ppm): 2.39 (s, 3H), 7.80 (dd, J = 3.0 Hz, JH-F = 8.2 Hz, 1H), 8.13 (dd, J = 2.7 Hz, JH-F = 8.2 Hz, 1H), 12.54 (br s, 1H); 13C NMR (DMSO-d6) δ (ppm): 21.6, 110.7 (d, JC-F = 23.0 Hz), 122.9 (d, JC-F = 9.7 Hz), 123.0 (d, JC-F = 8.8 Hz), 126.5 (d, JC-F = 26.6 Hz), 143.9 (d, JC-F = 2.7 Hz), 155.3 (d, JC-F = 1.8 Hz), 159.0 (d, JC-F = 247.7 Hz), 161.1 (d, JC-F = 3.5 Hz); HRMS (ESI+) m/z calculated value of C9H7N2BrF: 256.97203, measured value: 256.97205.

References

[1] Tetrahedron, 2012, vol. 68, # 2, p. 534 - 543

8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one synthesis

1352717-90-8
1352717-91-9
Synthesis of 8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one from 8-Bromo-6-fluoro-2-methyl-4H-benzo[d][1,3]oxazin-4-one

8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one Preparation Products And Raw materials

Raw materials

8-Bromo-6-fluoro-2-methyl-4H-benzo[d][1,3]oxazin-4-one Ammonia

Preparation Products

8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one Suppliers

Global Suppliers ( 14)
Supplier Tel Email Country ProdList Advantage
BePharm Ltd 400-685-9117 market@bepharm.com China 15081 60
Henan Alfachem Co.,Ltd. 0371-55051623 18137891487 3983243027@qq.com China 9974 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 021-4009004166/18616739031 18616739031 3007523370@qq.com China 40000 58
Jiangsu aikang biomedical research and development co., LTD 025-58859352 17714375163 qzhang@aikonchem.com China 15525 58
Career Henan Chemica Co +86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
Shanghai Kaiwei Chemical Technology Co., Ltd. 021-58461859 15821823057 service@aiviche.com China 49299 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44871 58
Bide Pharmatech Ltd. 400-6005915 sales@picasso-e.com China 39645 58
Shanghai Haohong Scientific Co., Ltd. 400-8210725 4008210725 malulu@leyan.com China 39319 58
Yantai Shengkailun Chemical Technology Co., Ltd. 13356901049 mark@sklnchem.cn China 9925 58
Supplier Advantage
BePharm Ltd 60
Henan Alfachem Co.,Ltd. 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 58
Jiangsu aikang biomedical research and development co., LTD 58
Career Henan Chemica Co 58
Shanghai Kaiwei Chemical Technology Co., Ltd. 58
Energy Chemical 58
Bide Pharmatech Ltd. 58
Shanghai Haohong Scientific Co., Ltd. 58
Yantai Shengkailun Chemical Technology Co., Ltd. 58

8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one Spectrum

8-Bromo-6-fluoro-2-methylquinazolin-4(3H)-one(1352717-91-9)1HNMR

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