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Batefenterol

Batefenterol Structure
Batefenterol structure
CAS No.
743461-65-6
Chemical Name:
Batefenterol
Synonyms
Batefenterol;GSK-961081,Batefenterol;Batefenterol(GSK961081);Batefenterol, 10 mM in DMSO;GSK-961081(Batefenterol/TD-5959);GSK961081;GSK-961081;GSK 961081;TD-5959;TD 5959;TD5959;BATEFENTEROL;Batefenterol, 98%, a novel muscarinic receptor antagonist and β2-adrenoceptor agonist;GSK-961081,mAChR,inhibit,TD 5959,Muscarinic acetylcholine receptor,GSK 961081,Adrenergic Receptor,Batefenterol,Inhibitor,TD5959,Beta Receptor;(R)-1-(3-((2-Chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate;Carbamic acid, N-[1,1'-biphenyl]-2-yl-, 1-[3-[[2-chloro-4-[[[(2R)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl]amino]methyl]-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester
CBNumber:
CB13145992
Molecular Formula:
C40H42ClN5O7
Molecular Weight:
740.24
MDL Number:
MFCD27987925
MOL File:
743461-65-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:32:01
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Batefenterol Properties

Boiling point 948.3±65.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:67.0(Max Conc. mg/mL);90.51(Max Conc. mM)
form A crystalline solid
pka 8.89±0.20(Predicted)
color Light yellow to yellow
FDA UNII 1IAT42T80T

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Batefenterol price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21793 Batefenterol ≥98% 743461-65-6 1mg $54 2026-04-30 Buy
Cayman Chemical 21793 Batefenterol ≥98% 743461-65-6 5mg $223 2026-04-30 Buy
Cayman Chemical 21793 Batefenterol ≥98% 743461-65-6 10mg $418 2026-04-30 Buy
Cayman Chemical 21793 Batefenterol ≥98% 743461-65-6 25mg $913 2026-04-30 Buy
Biosynth TEB46165 Batefenterol 743461-65-6 25mg $1112.25 2026-06-05 Buy
Product number Packaging Price Buy
21793 1mg $54 Buy
21793 5mg $223 Buy
21793 10mg $418 Buy
21793 25mg $913 Buy
TEB46165 25mg $1112.25 Buy

Batefenterol Chemical Properties, Uses, Production

Uses

Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.

in vivo

In the guinea pig bronchoprotection assay, inhaled Batefenterol produces potent, dose-dependent inhibition of bronchoconstrictor responses via MA (ED50=33.9 μg/mL), BA (ED50=14.1 μg/mL), and MABA (ED50=6.4 μg/mL) mechanisms. Significant bronchoprotective effects of Batefenterol are evident in guinea pigs via MA, BA, and MABA mechanisms for up to 7 days after dosing[1]. In guinea pig isolated trachea expressing native muscarinic M3 and β2, batefenterol produces smooth muscle relaxation through a dual mechanism involving competitive antagonism of the M3 receptor (EC50=50 nM) and agonism of the β2 receptor (EC50=25 nM). The combined effect on both muscarinic receptors and β2 receptors is more potent than either function working alone (EC50=10 nM). Batefenterol exhibits a rapid rate of clearance and short half-life[2].

IC 50

mAChR2; mAChR3

References

[1] Hegde SS, et al. Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties. J Pharmacol Exp Ther. 2014 Oct;351(1):190-9. DOI:10.1124/jpet.114.216861
[2] Hughes AD, et al. Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): first-in-class dual pharmacology multivalent muscarinic antagonist and β agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD). J Med Chem. 2015 Mar 26;58(6):2609-22. DOI:10.1021/jm501915g

Batefenterol synthesis

171722-92-2
743461-65-6
Synthesis of Batefenterol from piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate

Batefenterol Preparation Products And Raw materials

Raw materials

1-Piperidinecarboxylic acid, 4-[(1H-imidazol-1-ylcarbonyl)oxy]-, 1,1-dimethylethyl ester Carbamic acid, N-[1,1'-biphenyl]-2-yl-, 1-[3-[[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate 2-Aminobiphenyl

Preparation Products

Batefenterol Suppliers

Global Suppliers ( 76)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2969 58
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Medi-tech Bioscientific Co., Ltd. 0519-83246372 13585352506 China 1838 58
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai Rechem science Co., Ltd. 58
Shanghai SuperLan Chemcial Technique Centre 58
Amadis Chemical Company Limited 58
Medi-tech Bioscientific Co., Ltd. 58

View Latest Price from Batefenterol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Batefenterol pictures 2026-04-21 Batefenterol
743461-65-6
 $41.00-156.00 97.94% 10g TargetMol Chemicals Inc.
  • Batefenterol pictures
  • Batefenterol
    743461-65-6
  • $41.00-156.00
  • 97.94%
  • TargetMol Chemicals Inc.

Batefenterol Spectrum

Batefenterol(743461-65-6)1HNMR

743461-65-6 (Batefenterol) Related Search:

Batefenterol Glycopyrrolate Aclidinium bromide Theophylline-d6 Umeclidinium bromide
Ipratropium bromide

1of2

GSK961081;GSK-961081;GSK 961081;TD-5959;TD 5959;TD5959;BATEFENTEROL Batefenterol (R)-1-(3-((2-Chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate GSK-961081,Batefenterol GSK-961081(Batefenterol/TD-5959) Batefenterol, 98%, a novel muscarinic receptor antagonist and β2-adrenoceptor agonist Batefenterol(GSK961081) Carbamic acid, N-[1,1'-biphenyl]-2-yl-, 1-[3-[[2-chloro-4-[[[(2R)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl]amino]methyl]-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester GSK-961081,mAChR,inhibit,TD 5959,Muscarinic acetylcholine receptor,GSK 961081,Adrenergic Receptor,Batefenterol,Inhibitor,TD5959,Beta Receptor Batefenterol, 10 mM in DMSO 743461-65-6 C40H42ClN5O7 APIs