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ChemicalBook >> CAS DataBase List >>ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate

ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate

ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Structure
ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate structure
CAS No.
139308-52-4
Chemical Name:
ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate
Synonyms
ethyl 3-bromo-1-methyl-pyrazole-4-carboxylate;ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate;3-Bromo-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester;1H-Pyrazole-4-carboxylic acid, 3-bromo-1-methyl-, ethyl ester
CBNumber:
CB13376860
Molecular Formula:
C7H9BrN2O2
Molecular Weight:
233.06
MDL Number:
MFCD22420858
MOL File:
139308-52-4.mol
MSDS File:
SDS
Last updated:2026-05-27 23:43:31
Product description Number Pack Size Price
Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate 304922 250.00mg $100
Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate 304922 1.00g $276
Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate 304922 5.00g $1109
Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate 95% E46313 100mg $97
Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate 95% E46313 250mg $110
Request For Quotation

ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Properties

Boiling point 290.7±20.0 °C(Predicted)
Density 1.58±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -2.40±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338

ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 304922 Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate 139308-52-4 250.00mg $100 2026-05-19 Buy
Matrix Scientific 304922 Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate 139308-52-4 1.00g $276 2026-05-19 Buy
Matrix Scientific 304922 Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate 139308-52-4 5.00g $1109 2026-05-19 Buy
Synthonix E46313 Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate 95% 139308-52-4 100mg $97 2026-05-06 Buy
Synthonix E46313 Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate 95% 139308-52-4 250mg $110 2026-05-06 Buy
Product number Packaging Price Buy
304922 250.00mg $100 Buy
304922 1.00g $276 Buy
304922 5.00g $1109 Buy
E46313 100mg $97 Buy
E46313 250mg $110 Buy

ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Chemical Properties,Uses,Production

Synthesis

1-H-pyrazole-4-carboxylic acid,3-broMo,ethyl ester

1353100-91-0

Iodomethane

74-88-4

Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate

105486-72-4

ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate

139308-52-4

To a solution of ethyl 3-bromopyrazole-4-carboxylate (5.6 g, 25.57 mmol) in DMF (200 ml) was added iodomethane (14.52 g, 102.28 mmol, 6.37 ml) and cesium carbonate (33.32 g, 102.28 mmol). The reaction mixture was stirred at 25°C for 12 hours. After completion of the reaction, the mixture was diluted with deionized water (1000 ml) and extracted with ethyl acetate (500 ml). The organic layer was subsequently washed with saturated brine (500 ml x 3), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was initially purified (4 g) by preparative HPLC (alkaline conditions). Further purification by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 10/1 to 5:1) afforded ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate (1 g, yield: 16.8%) and ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate (2 g, yield: 33.6%), both as white solid.

References

[1] Patent: WO2018/64119, 2018, A1. Location in patent: Paragraph 0506; 0936

ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Preparation Products And Raw materials

Raw materials

1-H-pyrazole-4-carboxylic acid,3-broMo,ethyl ester Iodomethane N,N-Dimethylformamide Cesium carbonate

Preparation Products

ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Suppliers

Global( 32)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		tp@aladdinsci.com United States 54746 58
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 17321281695 18019252918 sale@amkchem.com China 14982 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163 yftan@aikonchem.com China 16674 50
SuZhou ShiYa Biopharmaceuticals, Inc. 0512-0512-52358471 17715136450 sales@shiyabiopharm.com China 9814 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Suzhou Baosheng Pharmaceutical Technology Co., Ltd., 18616776591 xuchenghao@sinch.com.cn China 263 58
Chengdu Feibai Pharmaceutical Co., Ltd. 028-84641798 18782128315 3302391190@qq.com China 6116 55
LEADMEDPHARM CO.,LTD 13674959855 13674959855 sales@synthontech.com China 3025 58
Changzhou Xuanye Technology Co., Ltd 15195022192; 279776773@qq.com China 2000 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
Supplier Advantage
Aladdin Scientific 		58
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 50
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Suzhou Baosheng Pharmaceutical Technology Co., Ltd., 58
Chengdu Feibai Pharmaceutical Co., Ltd. 55
LEADMEDPHARM CO.,LTD 58
Changzhou Xuanye Technology Co., Ltd 58
Energy Chemical 58

ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Spectrum

ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate(139308-52-4)1HNMR

139308-52-4(ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate)Related Search:

HOOCCH2O-PEG6-CH2COOH ETHOXY-IMINO-ACETIC ACID ETHYL ESTER Dabigatran iMpurity K Ethyl 2-aMino-1H-indol-3-carboxylate HCl 2-Thiophenecarboxylic acid, 3-amino-5-(1,3-benzodioxol-5-yl)-, ethyl ester
Dabigatran Impurity 37 5-Amino-1-benzyl-1,2,3,6-tetrahydro-pyridine-4-carboxylic acid ethyl ester Benzoic acid, 2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester 5-(Ethoxycarbonyl)thiophene-2-boronic acid,pinacol ester Ethyl 6-chloro-1H-pyrrolo[3,2-c]pyridine-3-carboxylate
Ethyl 6-(1,4-Diazepan-1-yl)pyridine-3-carboxylate Hydrochloride ethyl 3-imino-2-(piperidin-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxylate dihydrochloride Pentanoic acid, 4-methyl-2-methylene-, ethyl ester 2-OXO-3-QUINOLIN-2-YL-PROPIONIC ACID ETHYL ESTER 1H-Indole-2-carboxylic acid, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester
3-Furancarboxylic acid, 4,5-dihydro-2-methyl-4-oxo-, ethyl ester

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ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate 3-Bromo-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester 1H-Pyrazole-4-carboxylic acid, 3-bromo-1-methyl-, ethyl ester ethyl 3-bromo-1-methyl-pyrazole-4-carboxylate 139308-52-4