ZTMSSDQFJNEUNG-WMMXXEOUSA-N
- CAS No.
- 1429386-01-5
- Chemical Name:
- ZTMSSDQFJNEUNG-WMMXXEOUSA-N
- Synonyms
- AM 8735,AM8735;ZTMSSDQFJNEUNG-WMMXXEOUSA-N;2-Morpholineacetic acid, 6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(1S)-1-cyclopropyl-2-[(1,1-dimethylethyl)sulfonyl]ethyl]-3-oxo-, (2R,5R,6R)-
- CBNumber:
- CB13387512
- Molecular Formula:
- C27H31Cl2NO6S
- Molecular Weight:
- 568.51
- MDL Number:
- MFCD28963896
- MOL File:
- 1429386-01-5.mol
ZTMSSDQFJNEUNG-WMMXXEOUSA-N Chemical Properties,Uses,Production
Description
AM-8735 is a selective and potent inhibitor of the MDM2-p53 protein-protein interaction.
Uses
AM-8735 is a potent and selective MDM2 inhibitor with an IC50 of 25 nM.
in vivo
AM-8735 also demonstrates significant time and concentration dependent p21 mRNA induction in vivo in a pharmacodynamic assay in SJSA-1 osteosarcoma tumors. AM-8735 shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with an ED50 of 41 mg/kg[1].
References
[1] Gonzalez AZ, et al. Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. J Med Chem. 2014 Mar 27;57(6):2472-88. DOI:10.1021/jm401767k
ZTMSSDQFJNEUNG-WMMXXEOUSA-N Preparation Products And Raw materials
Raw materials
Preparation Products
ZTMSSDQFJNEUNG-WMMXXEOUSA-N Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38838 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19939 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| cjbscvictory | 13348960310 | 3003867561@qq.com | China | 10523 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24982 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
