3-Methoxyphenylacetic acid
- CAS No.
- 1798-09-0
- Chemical Name:
- 3-Methoxyphenylacetic acid
- Synonyms
- 2-(3-METHOXYPHENYL)ACETIC ACID;AKOS BBS-00006497;RARECHEM AL BO 0124;m-Anisyl-acetic Acid;Atenolol Impurity 44;MethoxyphenylaceticAci;3-MeO-phenylacetic acid;M-METHOXY-A-TOLUIC ACID;3-Methoxyphenylessigsure;Between the Methoxy acid
- CBNumber:
- CB1350236
- Molecular Formula:
- C9H10O3
- Molecular Weight:
- 166.17
- MDL Number:
- MFCD00004334
- MOL File:
- 1798-09-0.mol
- MSDS File:
- SDS
| Melting point | 65-69 °C (lit.) |
|---|---|
| Boiling point | 306 °C |
| Density | 1.1708 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in Chloroform and Ethyl Acetate. |
| form | Flakes |
| pka | 4.19±0.10(Predicted) |
| color | White to slightly yellow |
| Water Solubility | SLIGHTLY SOLUBLE |
| BRN | 2614004 |
| InChI | InChI=1S/C9H10O3/c1-12-8-4-2-3-7(5-8)6-9(10)11/h2-5H,6H2,1H3,(H,10,11) |
| InChIKey | LEGPZHPSIPPYIO-UHFFFAOYSA-N |
| SMILES | C1(CC(O)=O)=CC=CC(OC)=C1 |
| LogP | 1.500 |
| CAS DataBase Reference | 1798-09-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 25XLO0T6MY |
| NIST Chemistry Reference | Benzeneacetic acid, 3-methoxy-(1798-09-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338+P310 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AI8940000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29189090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 | |||||||||
| NFPA 704 |
|
3-Methoxyphenylacetic acid price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M19007 | 3-Methoxyphenylacetic acid ≥99% | 1798-09-0 | 5g | $49.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | M19007 | 3-Methoxyphenylacetic acid ≥99% | 1798-09-0 | 25g | $145 | 2026-04-30 | Buy |
| TCI Chemical | M0858 | 3-Methoxyphenylacetic Acid >98.0%(T) | 1798-09-0 | 25g | $95 | 2026-04-30 | Buy |
| TRC | TRC-M265770-5G | 3-Methoxyphenylacetic Acid | 1798-09-0 | 5g | $65 | 2026-06-03 | Buy |
| TRC | TRC-M265770-25G | 3-Methoxyphenylacetic Acid | 1798-09-0 | 25g | $109 | 2026-06-03 | Buy |
3-Methoxyphenylacetic acid Chemical Properties, Uses, Production
Synthesis
In a 1000ml three-necked flask, add 33g of sublimed sulfur, 96.5ml of 3-methoxyacetophenone (V), and 92ml of morpholine, and reflux for 15 hours with mechanical stirring. Cool to about 30°C, and add a mixed solution prepared from 350ml of glacial acetic acid, 105ml of distilled water, and 70ml of concentrated sulfuric acid with mechanical stirring, and continue reflux for 5.5 hours. Pour the reaction mixture into ice water (400g ice + 100ml water), and stir mechanically until a yellowish-brown solid precipitates (add crushed ice if necessary), then rapidly cool and filter under ice bath conditions.
The solid was dissolved in 300 ml of 20% sodium hydroxide aqueous solution, filtered, and the brown insoluble matter was added to 100 ml of 20% sodium hydroxide aqueous solution and heated under reflux for half an hour, then filtered while hot. The filtrates were combined, and 10 g of activated powdered activated carbon was added and refluxed for half an hour for decolorization. The mixture was then filtered. 15 g of Raney Ni was added as a catalyst and refluxed and stirred for 2 hours to remove the reacted Ni. Another 15 g of Raney Ni was added and refluxed for 2 hours. The mixture was filtered, and the filtrate was acidified to pH 1-2 with 2N hydrochloric acid under ice bath and mechanical stirring to obtain a feathery white precipitate. This precipitate was placed under ice bath for half an hour, filtered, and dried to obtain 58 g of 3-Methoxyphenylacetic acid, with a yield of 49.8% and a melting point of 68-71℃.Chemical Properties
Off-White Solid
Uses
A fluorimetric method for the estimation of 4-hydroxy-3-methoxyphenylacetic acid (homovanillic acid) has been developed and applied to normal brain tissue. The presence of homovanillic acid in the caudate nucleus of normal animals of several species has been demonstrated.
Definition
ChEBI: 3-Methoxyphenylacetic acid is a monocarboxylic acid.
Purification Methods
Crystallise the acid from H2O, or aqueous EtOH. The S-benzylisothiuronium salt has m 160-161o (from EtOH). [Beilstein 10 I 82, 10 III 428, 10 IV 541.]
3-Methoxyphenylacetic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Yontinotech Co.,Ltd | 028-86293627 15228898511 | sales@yontinotech.com | China | 106 | 56 |
| Shandong fen Boyu Biotechnology Co.,LTD | 13356310019 13356310019; | boyu2024@163.com | China | 3947 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing dtftchem Technology Co., Ltd. | 010-60275820 13031183356 | elainezt@sina.com | China | 1386 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from 3-Methoxyphenylacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-08 | 3-Methoxyphenylacetic acid
1798-09-0
|
$29.00 | 99.45% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-08-08 | 3-Methoxyphenylacetic acid
1798-09-0
|
$29.00 | 99.45% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | 3-Methoxyphenylacetic acid
1798-09-0
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 3-Methoxyphenylacetic acid
1798-09-0
- $29.00
- 99.45%
- TargetMol Chemicals Inc.
-
- 3-Methoxyphenylacetic acid
1798-09-0
- $29.00
- 99.45%
- TargetMol Chemicals Inc.
-
- 3-Methoxyphenylacetic acid
1798-09-0
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
