N-Trityl-L-serine methyl ester
- CAS No.
- 4465-44-5
- Chemical Name:
- N-Trityl-L-serine methyl ester
- Synonyms
- Trt-Ser-OMe;Methyl trityl-L-serinate;(S)-methyl 3-hydroxy-2-(tritylamino)propanoate;methyl (2S)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate;Trt-L-Ser-Ome;Trt-L-Ser-Ome-OH;(diphenylMethyl)benzene;(4S)-4-aMinooxolan-3-one;Methyl N-trityl-L-serinate;N-TRITYL-L-SERINE METHYL ESTER
- CBNumber:
- CB1369166
- Molecular Formula:
- C23H23NO3
- Molecular Weight:
- 361.43
- MDL Number:
- MFCD00192570
- MOL File:
- 4465-44-5.mol
- MSDS File:
- SDS
| Melting point | 148-150 °C (lit.) |
|---|---|
| Boiling point | 538.2±50.0 °C(Predicted) |
| alpha | 31 º (c=1 in methanol) |
| Density | 1.169±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 14.01±0.10(Predicted) |
| color | White to Light yellow |
| optical activity | [α]20/D +31°, c = 1 in methanol |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C23H23NO3/c1-27-22(26)21(17-25)24-23(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16,21,24-25H,17H2,1H3/t21-/m0/s1 |
| InChIKey | LXAWQKKSNNYYEK-NRFANRHFSA-N |
| SMILES | C(OC)(=O)[C@H](CO)NC(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1 |
| FDA 21 CFR | 582.5701 |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29225090 |
| Storage Class | 11 - Combustible Solids |
N-Trityl-L-serine methyl ester price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 411345 | N-Trityl-L-serine methyl ester 99% | 4465-44-5 | 25g | $453 | 2026-04-30 | Buy |
| TCI Chemical | T2870 | N-(Triphenylmethyl)-L-serine Methyl Ester >98.0%(GC)(T) | 4465-44-5 | 5g | $58 | 2026-04-30 | Buy |
| TCI Chemical | T2870 | N-(Triphenylmethyl)-L-serine Methyl Ester >98.0%(GC)(T) | 4465-44-5 | 25g | $197 | 2026-04-30 | Buy |
| Activate Scientific | AS29880 | N-(Triphenylmethyl)-L-serine Methyl Ester 97%EE | 4465-44-5 | 5g | $23 | 2026-06-04 | Buy |
| Activate Scientific | AS29880 | N-(Triphenylmethyl)-L-serine Methyl Ester 97%EE | 4465-44-5 | 25g | $57 | 2026-06-04 | Buy |
N-Trityl-L-serine methyl ester Chemical Properties,Uses,Production
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
5680-80-8
76-83-5
13515-76-9
A solution of dichloromethane (CH2Cl2, 40 mL) with triethylamine (Et3N, 13.4 mL, 96.78 mmol) was slowly added dropwise to a dichloromethane (CH2Cl2, 129 mL) containing L-serine methyl ester hydrochloride (5.0 g, 32.26 mmol) and triphenylmethane chloride (Ph3CCl, 13.5 g, 48.39 mmol) solution and the reaction was carried out at 0 °C under the protection of nitrogen (N2). Subsequently, the reaction system was gradually warmed up to room temperature with continuous stirring overnight. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate (NaHCO3) solution and the aqueous phase was extracted with dichloromethane (CH2Cl2). The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford N-trityl-L-serine methyl ester as a colorless solid (11.41 g, 98% yield).
References
[1] Acta Chemica Scandinavica, 1994, vol. 48, # 6, p. 511 - 516
[2] Patent: WO2007/68474, 2007, A1. Location in patent: Page/Page column 51; 52
[3] Patent: WO2016/8946, 2016, A1. Location in patent: Page/Page column 101
[4] Angewandte Chemie - International Edition, 2017, vol. 56, # 40, p. 12245 - 12249
[5] Angew. Chem., 2017, vol. 129, p. 12413 - 12417,5
N-Trityl-L-serine methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Bosennuokang Pharmaceutical Technology Co., Ltd. | 010-86203349 18201082367 | bosennuokang@163.com | China | 288 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7882 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Lastest Price from N-Trityl-L-serine methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Trt-L-Ser-Ome
4465-44-5
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2019-07-06 | N-Trityl-L-serine methyl ester
4465-44-5
|
$1.00 | 1KG | 99% | 20kg | Career Henan Chemical Co |
-
- Trt-L-Ser-Ome
4465-44-5
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- N-Trityl-L-serine methyl ester
4465-44-5
- $1.00
- 99%
- Career Henan Chemical Co
