Methyl benzenesulfonate
- CAS No.
- 80-18-2
- Chemical Name:
- Methyl benzenesulfonate
- Synonyms
- Methyl Besylate;BENZENESULFONIC ACID METHYL ESTER;20ND3-5;nsc06624;ai3-06624;AKOS BBS-00004424;Methyl benzenesulfon;Methylbenzoxysulfonate;METHYL BENZENESULFONATE;Methyl Benzensulfonate
- CBNumber:
- CB0776273
- Molecular Formula:
- C7H8O3S
- Molecular Weight:
- 172.2
- MDL Number:
- MFCD00014737
- MOL File:
- 80-18-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -4 °C |
|---|---|
| Boiling point | 147-150°C 13mm |
| Density | 1.3 |
| refractive index | 1.514-1.516 |
| Flash point | 143 °C |
| storage temp. | 2-8°C |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Liquid |
| color | Clear colorless to slightly yellow |
| Water Solubility | Miscible with chloroform, methanol, ethanol and ether. Immiscible with water. |
| BRN | 908448 |
| InChI | 1S/C7H8O3S/c1-10-11(8,9)7-5-3-2-4-6-7/h2-6H,1H3 |
| InChIKey | CZXGXYBOQYQXQD-UHFFFAOYSA-N |
| SMILES | COS(=O)(=O)c1ccccc1 |
| CAS DataBase Reference | 80-18-2(CAS DataBase Reference) |
| FDA UNII | 69X50842RM |
| NIST Chemistry Reference | Benzenesulfonic acid, methyl ester(80-18-2) |
| EPA Substance Registry System | Benzenesulfonic acid, methyl ester (80-18-2) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H314-H317 | |||||||||
| Precautionary statements | P261-P270-P280-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C,Xi | |||||||||
| Risk Statements | 34-22-43 | |||||||||
| Safety Statements | 28A-26-45-36/37/39 | |||||||||
| RIDADR | 3265 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DB7151000 | |||||||||
| Hazard Note | Irritant/Corrosive | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29051990 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Skin Corr. 1B Skin Sens. 1 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Methyl benzenesulfonate price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 165956 | Methyl benzenesulfonate 98% | 80-18-2 | 100g | $148 | 2026-04-30 | Buy |
| Sigma-Aldrich | 165956 | Methyl benzenesulfonate 98% | 80-18-2 | 500g | $526 | 2026-04-30 | Buy |
| TCI Chemical | B0033 | Methyl Benzenesulfonate >98.0%(GC) | 80-18-2 | 25mL | $39 | 2026-04-30 | Buy |
| TCI Chemical | B0033 | Methyl Benzenesulfonate >98.0%(GC) | 80-18-2 | 100mL | $98 | 2026-04-30 | Buy |
| TRC | TRC-M288890-250MG | Methyl Benzenesulfonate >95%(HPLC) | 80-18-2 | 250mg | $215 | 2026-06-03 | Buy |
Methyl benzenesulfonate Chemical Properties,Uses,Production
Description
Methyl benzenesulfonate is used as a raw material for the dye and pharmaceutical industries, used as an alkylating agent in organic synthesis for the production of some synthetic dye. It can also be used for the manufacturing the thin-cation exchanger film.
Preparation
Methyl benzenesulfonate is the effective methylating reagent of synthetic multiple organic intermediate, and industry is at present gone up and mainly adopted Phenylsulfonic acid and methyl alcohol to carry out after the esterification essence to steam, this technology starting material costliness, and reaction time is long, and product yield is low. How to get Methyl benzenesulfonate with high yield, scientists have lots of researcher.
Photolysis
Irradiation of methyl benzenesulfonate in methanol causes photolysis, yielding benzene (5–34%), biphenyl (9–15%), and phenethyl ether (trace amounts). The quantum yield of extinction at a wavelength of 254 nm at room temperature is estimated to be 0.07 ± 0.005 [1].
Genotoxicity
Methyl benzenesulfonate is a sulfonate ester which acts as a potential genotoxic impurity in drug substances. Further, it exerts genotoxic effects in bacterial and mammalian cell systems. Incompatible with strong oxidizing agents, strong acids and strong bases.
Reaction
V. M. Nesterov and I. E. Chubova prepared theobromine from 3-methylxanthine, methyl benzenesulfonate, which has been used as the methylating agent. To obtain theobromine, 3-methylxanthine is generally methylated with dimethyl sulfate in an aqueous ethanolic solution of caustic potash. However, if in the reaction the pH exceeds 8.0, the methylation of 3-methylxanthine leads to caffeine, which forms a by-product.
Chemical Properties
clear colourless to slightly brown liquid
Uses
A sulfonate ester as potential genotoxic impurity in drug substances.
Uses
Methyl benzenesulfonate is a sulfonate ester which acts as a potential genotoxic impurity in drug substances. Further, it exerts genotoxic effects in bacterial and mammalian cell systems.
References
[1] Y. Izawa, Naoki K. (1975). Photolysis of Methyl Benzenesulfonate in Methanol. Bulletin of the Chemical Society of Japan, 48 1, 3197–3199. https://doi.org/10.1246/bcsj.48.3197
Methyl benzenesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shouguang Nuomeng Chemical Co Ltd. | 0536-5399456 13869682027 | holly@nuomengchem.com | China | 47 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
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View Lastest Price from Methyl benzenesulfonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | Methyl benzenesulfonate
80-18-2
|
$1.00-122.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-25 | Methyl Benzenesulfonate, Methyl Benzene sulfonate
80-18-2
|
$4200.00 | 1KG | 99% Min. | 200 tons per month | Shouguang Nuomeng Chemical Co Ltd. | |
 |
2026-08-07 | Methyl Benzenesulfonate
80-18-2
|
$1.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- Methyl benzenesulfonate
80-18-2
- $1.00-122.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Methyl Benzenesulfonate, Methyl Benzene sulfonate
80-18-2
- $4200.00
- 99% Min.
- Shouguang Nuomeng Chemical Co Ltd.
-
- Methyl Benzenesulfonate
80-18-2
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
