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ChemicalBook >> CAS DataBase List >>2,2,6,6-Tetramethyl-3,5-heptanedione

2,2,6,6-Tetramethyl-3,5-heptanedione

2,2,6,6-Tetramethyl-3,5-heptanedione Structure
2,2,6,6-Tetramethyl-3,5-heptanedione structure
CAS No.
1118-71-4
Chemical Name:
2,2,6,6-Tetramethyl-3,5-heptanedione
Synonyms
TMHD;2,2,6,6-TETRAMETHYLHEPTANE-3,5-DIONE;DIPIVALOYLMETHANE;2,2,6,6-Tetramethyl heptanedione;2,2,6,6-Tetramethyl-3,5-heptadione;3,5-Heptanedione, 2,2,6,6-tetramethyl-;butan-1-ol,propan-2-ol,titanium;dpm-h;5-heptanedione;6-Tetramethyl-3
CBNumber:
CB1373637
Molecular Formula:
C11H20O2
Molecular Weight:
184.28
MDL Number:
MFCD00008848
MOL File:
1118-71-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-04 18:03:49
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2,2,6,6-Tetramethyl-3,5-heptanedione Properties

Melting point >400 °C (decomp)
Boiling point 72-73 °C/6 mmHg (lit.)
Density 0.883 g/mL at 25 °C (lit.)
refractive index n20/D 1.459(lit.)
Flash point 153 °F
storage temp. Sealed in dry,Room Temperature
solubility Difficult to mix.
form Liquid
pka 11.60±0.10(Predicted)
Specific Gravity 0.883
color Clear colorless to slightly yellow
BRN 1447269
InChI 1S/C11H20O2/c1-10(2,3)8(12)7-9(13)11(4,5)6/h7H2,1-6H3
InChIKey YRAJNWYBUCUFBD-UHFFFAOYSA-N
SMILES CC(C)(C)C(=O)CC(=O)C(C)(C)C
LogP 2.818 (est)
CAS DataBase Reference 1118-71-4(CAS DataBase Reference)
FDA UNII R8UI909HOY
EPA Substance Registry System 3,5-Heptanedione, 2,2,6,6-tetramethyl- (1118-71-4)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H227-H302
Precautionary statements  P210e-P264-P280a-P301+P312a-P501a-P210-P280-P370+P378-P403+P235-P501
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn
Risk Statements  22-40-36/37/38
Safety Statements  24/25-36-26-22
RIDADR  UN 1993 / PGIII
WGK Germany  3
TSCA  TSCA listed
HS Code  29141900
Storage Class 10 - Combustible liquids
NFPA 704
2
1 0

2,2,6,6-Tetramethyl-3,5-heptanedione price More Price(78)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 155756 2,2,6,6-Tetramethyl-3,5-heptanedione 98% 1118-71-4 5g $54.7 2026-04-30 Buy
Sigma-Aldrich 155756 2,2,6,6-Tetramethyl-3,5-heptanedione 98% 1118-71-4 25g $156 2026-04-30 Buy
TCI Chemical D1678 Dipivaloylmethane >97.0%(GC) 1118-71-4 5g $55 2026-04-30 Buy
TCI Chemical D1678 Dipivaloylmethane >97.0%(GC) 1118-71-4 25g $156 2026-04-30 Buy
Strem Chemicals 08-2050 2,2,6,6-Tetramethylheptane-3,5-dione, 98% TMHD 98% 1118-71-4 5g $41 2026-04-30 Buy
Product number Packaging Price Buy
155756 5g $54.7 Buy
155756 25g $156 Buy
D1678 5g $55 Buy
D1678 25g $156 Buy
08-2050 5g $41 Buy

2,2,6,6-Tetramethyl-3,5-heptanedione Chemical Properties, Uses, Production

Chemical Properties

CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID

Uses

suzuki reaction

Uses

2,2,6,6-tetramethyl-3,5-heptanedione was used in the synthesis of α-aryl-β-diketones1 and dicyanamidobenzene-bridge diruthenium complex.

Uses

2,2,6,6-Tetramethyl-3,5-heptanedione is a beta diketone with antibacterial activity.

Definition

2,2,6,6-Tetramethyl-3,5-heptanedioneis a stable, anhydrous reagent. It undergoes O-additions and C-additions. In various reactions, it acts as an air-stable ligand for metal catalysts. Furthermore, it serves as a substrate for heterocycles.

Synthesis Reference(s)

Journal of the American Chemical Society, 100, p. 5428, 1978 DOI: 10.1021/ja00485a030

General Description

Acylation, a replacement to silylation, allows the conversion of compounds that consist of active hydrogens (-OH, -SH and -NH) into esters, thioesters, and amides via the action of a carboxylic acid or derivative. The carbonyl group adjacent to the halogenated carbons is known to improve the electron capture detector (ECD) response. Acylation has several advantages:

  • It enhances the stability of compounds by protecting unstable groups.
  • It may confer volatility on substances like carbohydrates or amino acids, that have several polar groups that they are non-volatile and usually decompose on heating.
  • It facilitates the separations not possible with underivatized compounds.
  • Compounds are detectable at very low levels with an ECD.

2,2,6,6-Tetramethyl-3,5-heptanedione is a reagent used to form fragmentation-directing derivatives for GC/MS analysis.

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

Synthesis

Methyl pivalate and formamide could be used as starting materials to synthesize 2,2,6,6-Tetramethyl-3,5-heptanedione.
2,2,6,6-Tetramethyl-3,5-heptanedione   

2,2,6,6-Tetramethyl-3,5-heptanedione synthesis

62688-81-7
1118-71-4
Synthesis of 2,2,6,6-Tetramethyl-3,5-heptanedione from 4-Heptyn-3-one, 2,2,6,6-tetramethyl-

2,2,6,6-Tetramethyl-3,5-heptanedione Preparation Products And Raw materials

Raw materials

Sodium hydride Ethanol N,N-Dimethylformamide Pinacolone Tetrahydrofuran
Diethyl ether Ethyl acetate Methyl trimethylacetate Hydrochloric acid 4-Heptyn-3-one, 2,2,6,6-tetramethyl-
Benzenemethanamine, N-(1,2,2-trimethylpropylidene)- Dipivaloylamine 2,2-Dimethylpropanoic acid phenyl ester Propanamide,2,2-dimethyl-N-(phenylmethyl)- 2,3,3-Trimethyl-2-butanol
8-Hydroxyquinoline

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Preparation Products

N,N-Diphenylquinacridone 2,2,6,6-Tetramethyl-3,5-heptanedionato potassium 3,5-Heptanedione, 4-bromo-2,2,6,6-tetramethyl-

2,2,6,6-Tetramethyl-3,5-heptanedione Suppliers

Global Suppliers ( 407)
Supplier Tel Email Country ProdList Advantage
Wuhan EEChem Technologies Co., Ltd 0711-3617768 13308685235 lihongcai4360@sina.com China 1542 55
Changzhou Liren Medical Technology Co. Ltd. 0519-85859058 13915836899 2078957504@qq.com China 454 58
Shijiazhuang Qiyue Chemical Co. LTD 15369111890 sjzqiyuekeji@163.com China 342 58
Tongchuang Pharma(Suzhou). Co., Ltd. 0512-63263366 18912765016 tongtf110@sina.com China 984 62
Speranza Chemical Co., Ltd. 0755-21030354 18126410231 sales@speranzachem.com China 632 58
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Fuxin Pharmaceutical 021-50872116 13391048226 contact@fuxinpharm.com China 1614 58
Dancheng Huatai Biotechnology Co., Ltd. 13482210809 13482210809 hli@3wpharm.com China 357 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chemvon Biotechnology Co., Ltd 021-50790412 info@chemvon.com China 371 57
Supplier Advantage
Wuhan EEChem Technologies Co., Ltd 55
Changzhou Liren Medical Technology Co. Ltd. 58
Shijiazhuang Qiyue Chemical Co. LTD 58
Tongchuang Pharma(Suzhou). Co., Ltd. 62
Speranza Chemical Co., Ltd. 58
Beijing HwrkChemical Technology Co., Ltd 55
Fuxin Pharmaceutical 58
Dancheng Huatai Biotechnology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Chemvon Biotechnology Co., Ltd 57

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View Latest Price from 2,2,6,6-Tetramethyl-3,5-heptanedione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE pictures 2026-09-17 2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE
1118-71-4
 $195.00-205.00 25KG 98% 500kg Speranza Chemical Co., Ltd.
2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE pictures 2026-09-11 2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE
1118-71-4
 1KG ≥98% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
2,2,6,6-Tetramethyl-3,5-heptanedione pictures 2026-09-07 2,2,6,6-Tetramethyl-3,5-heptanedione
1118-71-4
 1kg 99%min 20tons HANGZHOU HAILAN CHEMICAL CO.,LTD.

2,2,6,6-Tetramethyl-3,5-heptanedione Spectrum

2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE(1118-71-4)MS2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE(1118-71-4)1HNMR2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE(1118-71-4)13CNMR2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE(1118-71-4)IR12,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE(1118-71-4)Raman2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE(1118-71-4)ESR

1118-71-4 (2,2,6,6-Tetramethyl-3,5-heptanedione) Related Search:

2,4-Hexanedione 2,2-Dimethyl-3-hexanone Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)yttrium(III) 2,6-Heptanedione Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)ytterbium
Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)dysprosium(III) Tris(dipivaloylmethanato)lanthanum Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)copper(II) 3,5-Heptanedione Barium bis(2,2,6,6-tetramethyl-3,5-heptanedionate) hydrate
GD(TMHD)3 2,2,6,6-Tetramethyl-3,5-heptanedione Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)lead(II) 2,6-Dimethyl-3,5-heptanedione Bismuth Tris(2,2,6,6-tetramethyl-3,5-heptanedionate)
2,2-Dimethyl-3,5-hexanedione 2,2-Dimethyl-3-heptanone 2,6-Dimethyl-3-heptanone

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(CH3)3CCOCH2COC(CH3)3 2,2,6,6-tetramethyl-5-heptanedione 2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE DIPIVALOYLMETHANE 2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE Dipivaloylmethane~Dpm-H~Tmhd-H 2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE, 95 % 2,2,6,6-Tetramethylheptane-3,5-dione,98%TMHD dpm-h 2,2,6,6-TETRAMETHYLHEPTANE-3,5-DIONE TMHD 2,2,6,6-Tetramethyl-3,5-heptanedione, 99+% 2,2,6,6-Tetramethyl-3,5-heptanedione, 98+% 1,3-Di-tert-butyl-1,3-propanedione 2,2,6,6-Tetramethylheptane-3,5-dione, 99% TMHD 2,2,6,6-TetraMethyl-3,5-heptanedione, 98% 5GR 2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE FOR 2,2,6,6-TetraMethyl-3,5-heptan Dipivaloylmethane, 3,5-Dioxo-2,2,6,6-tetramethylheptane 2,2,6,6-TetraMethylheptane-3,5-dione SynonyMs 1,3-Di-tert-butyl-1,3-propanedione 2,2,6,6-Tetramethylheptane-3,5-dione 98% 5-heptanedione 6-Tetramethyl-3 Dipivaloylmethane> DIPIVALOYALMETHANE -3,5-heptanedione butan-1-ol,propan-2-ol,titanium 2,2,6,6-Tetramethylheptane-3,5-dione 1118-71-4 Di-tert-pentylmethane 2,2,6,6-tetramethyl-3,5-heptyldione TMHD 2,2,6,6-Tetramethyl-3,5-heptadione 2,2,6,6-Tetramethyl heptanedione 2,2,6,6-TETRAMETHYLHEPTANE-3,5-DIONE 3,5-Heptanedione, 2,2,6,6-tetramethyl- DIPIVALOYLMETHANE 1118-71-4 11188-71-4 C11H20O2 KETONE Ligands (Environmentally-friendly Oxidation) Environmentally-friendly Oxidation C11 to C12 Carbonyl Compounds Acylation Building Blocks Organic Building Blocks Ketones Achiral Oxygen organic compound Environmentally-friendly Oxidation Ligands (Environmentally-friendly Oxidation) Synthetic Organic Chemistry CHIRAL CHEMICALS