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2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine structure

CAS No.: 7355-55-7

Chemical Name:: 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine

Synonyms: Aids045539;OK-B-01044;Aids-045539;deazaguanine;7-DEAZAGUANINE;7-Deazaguanine,97%;Propranolol Impurity 12;2-amino-1H-pyrrolo[2,3-d]pyrimidin-4-ol;2-AMINO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-OL;2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi

CBNumber:: CB1379134

Molecular Formula:: C6H6N4O

Molecular Weight:: 150.14

MDL Number:: MFCD09033259

MOL File:: 7355-55-7.mol

MSDS File:: SDS

Last updated:2026-01-26 13:56:28

Product description	Number	Pack Size	Price
7-Deazaguanine	D1810-10	5g	$319
7-Deazaguanine	D201325	1g	$70
7-Deazaguanine	FD08308	2g	$80
2-Amino-7H-pyrrolo[2,3-d]pyrimidin-4-ol	066664	1g	$84
7-Deazaguanine	FD08308	1g	$50
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2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine Properties

Melting point	>230°C (dec.)
Density	1.87±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Soluble in N,N-Dimethylformamide, Dimethyl sulfoxide.
form	crystalline
pka	10.83±0.20(Predicted)
color	tan
CAS DataBase Reference	7355-55-7(CAS DataBase Reference)
FDA UNII	GPL8T5ZO3M

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Risk Statements

36/37/38

Safety Statements

26-37-60

RIDADR

2811

WGK Germany

HazardClass

6.1(a)

PackingGroup

HS Code

29339900

NFPA 704

	1
2		0

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	D1810-10	7-Deazaguanine	7355-55-7	5g	$319	2021-12-16	Buy
TRC	D201325	7-Deazaguanine	7355-55-7	1g	$70	2021-12-16	Buy
Biosynth Carbosynth	FD08308	7-Deazaguanine	7355-55-7	2g	$80	2021-12-16	Buy
Matrix Scientific	066664	2-Amino-7H-pyrrolo[2,3-d]pyrimidin-4-ol	7355-55-7	1g	$84	2021-12-16	Buy
Biosynth Carbosynth	FD08308	7-Deazaguanine	7355-55-7	1g	$50	2021-12-16	Buy

Product number	Packaging	Price	Buy
D1810-10	5g	$319	Buy
D201325	1g	$70	Buy
FD08308	2g	$80	Buy
066664	1g	$84	Buy
FD08308	1g	$50	Buy

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine Chemical Properties,Uses,Production

Chemical Properties

Pink solid

Uses

Ethidium bromide efficiently intercalates into synthetic duplex DNAs with 7-deazaguanine in place of guanine, but shows none of the fluorescence enhancement usually observed upon intercalation. 7-Deazaadenine-duplexes show about 70% of the expected fluorescence enhancement.

Definition

ChEBI: DG is 7-deazaguanine

Synthesis

100643-27-4

2032-35-1

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine

7355-55-7

To a suspension of bromoacetaldehyde diethyl acetal (10.4 mL, 68.98 mmol) in water (35 mL) was slowly added concentrated hydrochloric acid (1.5 mL). The reaction mixture was stirred at 90 °C for 30 min. Upon completion of the reaction, the solution was cooled to room temperature, followed by the addition of sodium acetate (6.8 g, 82.75 mmol). This mixed solution was slowly added to a suspension in water (75 mL) containing 2,4-diamino-6-hydroxypyrimidine (10.0 g, 79.29 mmol) and sodium acetate (3.5 g, 42.82 mmol). The reaction mixture was continued to be stirred at 80 °C for 2 hours. At the end of the reaction, the mixture was cooled to 0 °C and stirred for 90 min to promote crystallization. The precipitate was collected by filtration and washed sequentially with a small amount of cold water and acetone to afford the target product 2-amino-4-hydroxypyrrolo[2,3-d]pyrimidine (11.9 g, quantitative yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 10.97 (s, 1H), 10.23 (s, 1H), 6.61-6.60 (m, 1H), 6.18-6.17 (m, 1H), 6.05 (s, 2H).

IC 50

DYRK1A

References

[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 21, p. 5596 - 5611
[2] European Journal of Organic Chemistry, 2010, # 34, p. 6517 - 6519
[3] Patent: CN103601779, 2016, B. Location in patent: Paragraph 0057; 0058; 0059
[4] Patent: CN104292117, 2016, B. Location in patent: Paragraph 0476; 0499-0501
[5] Patent: WO2014/11911, 2014, A2. Location in patent: Paragraph 00252; 00253; 00254

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Chloroacetaldehyde 4-Pyrimidinol, 2,6-diamino- (9CI) Bromoacetaldehyde diethyl acetal 2,4-Diamino-6-hydroxypyrimidine Bromoacetaldehyde

Sodium acetate Hydrochloric acid

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Preparation Products

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine Suppliers

Global( 176)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	11727	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32470	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shanghai Arbor Chemical Co., Ltd.	58
Nanjing Baifuli Technology Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Zhengzhou Alfa Chemical Co.,Ltd	58
TargetMol Chemicals Inc.	58

View Lastest Price from 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-26	2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi 7355-55-7	US $0.00 / removed		99.42%	10g	TargetMol Chemicals Inc.
2022-09-12	2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine 7355-55-7	US $0.00-0.00 / G	1G	98%min	50kg/month	Shanghai Rlavie Technology Co ltd
2019-07-06	2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine 7355-55-7	US $8.80 / KG	1KG	97%-99%	100kg	Career Henan Chemical Co

2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
7355-55-7
US $0.00 / removed
99.42%
TargetMol Chemicals Inc.

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine
7355-55-7
US $0.00-0.00 / G
98%min
Shanghai Rlavie Technology Co ltd

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine
7355-55-7
US $8.80 / KG
97%-99%
Career Henan Chemical Co

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine Spectrum

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine(7355-55-7)¹HNMR

7355-55-7(2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine)Related Search:

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7-DEAZA-2'-DEOXYGUANOSINE 5'-O-(4,4'-DIMETHOXYTRITYL)-N2-DIMETHYLAMINOMETHYLENE-7-DEAZA-2'-DEOXYGUANOSINE, 3'-[(2-CYANOETHYL)-(N,N-DIISOPROPYL)]PHOSPHORAMIDITE 2'-Deoxy-L-guanosine 5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-7-DEAZA-2'-DEOXYGUANOSI NE 2-AMINO-4-METHOXY-7-(BETA-D-2-DEOXYRIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE

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2-AMINO-6-ETHYL-3,7-DIHYDRO-PYRROLO[2,3-D]PYRIMIDIN-4-ONE 7-DEAZAGUANOSINE, [8-3H(N)]- 2-AMINO-4-METHOXY-7-METHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID

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deazaguanine 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine 7-Deazaguanine 2-amino-1H-pyrrolo[2,3-d]pyrimidin-4-ol 2-Amino-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one 2-AMINO-3,7-DIHYDRO-PYRROLO[2,3-D]PYRIMIDIN-4-ONE 2-AMINO-4-HYDROXY-7H-PYRROLO[2,3-DPYRIMIDINE] 2-AMINO-4-HYDROXYPYRROLO-[2,3-D]PYRIMIDINE 2-AMINO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-OL 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-1,7-dihydro- (9CI) 2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidine 7-DEAZAGUANINE 2-amino-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one Aids045539 Aids-045539 2-Amino-3,7-dihydro-4Hpyrrolo[2,3-d]pyrimidin-4-one 2-aMino-3H,4H,7H-pyrrolo[2,3-d]pyriMidin-4-one 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-1,7-dihydro- 2-amino-1,7-dihydropyrrolo[2,3-d]pyrimidin-4-one 2-Amino-7H-pyrrolo[2,3-d]pyrimidin-4-ol 95+% 2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi OK-B-01044 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-3,7-dihydro- 7-Deazaguanine,97% 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine USP/EP/BP 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidin Propranolol Impurity 12 7355-55-7 Enzyme Inhibitors Enzymes, Inhibitors, and Substrates Enzyme Inhibitors by Type Substrate Analogs Biochemicals and Reagents BioChemical PYRIMIDINE AMINEPRIMARY Heterocyclic Series Heterocyclic Compounds Bases & Related Reagents Heterocycles Intermediates Nucleotides