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2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine structure

CAS No.: 7355-55-7

Chemical Name:: 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine

Synonyms: 7-DEAZAGUANINE;2-AMINO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-OL;2-AMINO-3,7-DIHYDRO-PYRROLO[2,3-D]PYRIMIDIN-4-ONE;Aids045539;OK-B-01044;Aids-045539;deazaguanine;7-Deazaguanine,97%;Propranolol Impurity 12;2-amino-1H-pyrrolo[2,3-d]pyrimidin-4-ol

CBNumber:: CB1379134

Molecular Formula:: C6H6N4O

Molecular Weight:: 150.14

MDL Number:: MFCD09033259

MOL File:: 7355-55-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-16 07:06:08

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2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine Properties

Melting point	>230°C (dec.)
Density	1.87±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Soluble in N,N-Dimethylformamide, Dimethyl sulfoxide.
form	crystalline
pka	10.83±0.20(Predicted)
color	tan
CAS DataBase Reference	7355-55-7(CAS DataBase Reference)
FDA UNII	GPL8T5ZO3M

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Risk Statements

36/37/38

Safety Statements

26-37-60

RIDADR

2811

WGK Germany

HazardClass

6.1(a)

PackingGroup

HS Code

29339900

NFPA 704

	1
2		0

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine price More Price(77)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-D201325-5G	7-Deazaguanine	7355-55-7	5g	$319	2026-06-03	Buy
TRC	TRC-D201325-500MG	7-Deazaguanine	7355-55-7	500mg	$73	2026-06-03	Buy
TRC	TRC-D201325-1G	7-Deazaguanine	7355-55-7	1g	$97	2026-06-03	Buy
Biosynth	FD08308	7-Deazaguanine	7355-55-7	5g	$302.3	2026-06-04	Buy
Biosynth	FD08308	7-Deazaguanine	7355-55-7	10g	$518.3	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-D201325-5G	5g	$319	Buy
TRC-D201325-500MG	500mg	$73	Buy
TRC-D201325-1G	1g	$97	Buy
FD08308	5g	$302.3	Buy
FD08308	10g	$518.3	Buy

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine Chemical Properties, Uses, Production

Chemical Properties

Pink solid

Uses

Ethidium bromide efficiently intercalates into synthetic duplex DNAs with 7-deazaguanine in place of guanine, but shows none of the fluorescence enhancement usually observed upon intercalation. 7-Deazaadenine-duplexes show about 70% of the expected fluorescence enhancement.

Definition

ChEBI: DG is 7-deazaguanine

Synthesis

100643-27-4

2032-35-1

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine

7355-55-7

To a suspension of bromoacetaldehyde diethyl acetal (10.4 mL, 68.98 mmol) in water (35 mL) was slowly added concentrated hydrochloric acid (1.5 mL). The reaction mixture was stirred at 90 °C for 30 min. Upon completion of the reaction, the solution was cooled to room temperature, followed by the addition of sodium acetate (6.8 g, 82.75 mmol). This mixed solution was slowly added to a suspension in water (75 mL) containing 2,4-diamino-6-hydroxypyrimidine (10.0 g, 79.29 mmol) and sodium acetate (3.5 g, 42.82 mmol). The reaction mixture was continued to be stirred at 80 °C for 2 hours. At the end of the reaction, the mixture was cooled to 0 °C and stirred for 90 min to promote crystallization. The precipitate was collected by filtration and washed sequentially with a small amount of cold water and acetone to afford the target product 2-amino-4-hydroxypyrrolo[2,3-d]pyrimidine (11.9 g, quantitative yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 10.97 (s, 1H), 10.23 (s, 1H), 6.61-6.60 (m, 1H), 6.18-6.17 (m, 1H), 6.05 (s, 2H).

IC 50

DYRK1A

References

[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 21, p. 5596 - 5611
[2] European Journal of Organic Chemistry, 2010, # 34, p. 6517 - 6519
[3] Patent: CN103601779, 2016, B. Location in patent: Paragraph 0057; 0058; 0059
[4] Patent: CN104292117, 2016, B. Location in patent: Paragraph 0476; 0499-0501
[5] Patent: WO2014/11911, 2014, A2. Location in patent: Paragraph 00252; 00253; 00254

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Chloroacetaldehyde 4-Pyrimidinol, 2,6-diamino- (9CI) Bromoacetaldehyde diethyl acetal 2,4-Diamino-6-hydroxypyrimidine Bromoacetaldehyde

Sodium acetate Hydrochloric acid

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Preparation Products

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine Suppliers

Global Suppliers ( 183)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
ChangZhou SIDU chemical Co., Ltd.	0519-81291281 18015082300	siduchem@hotmail.com	China	274	62
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
Shanghai Sphchem Co., Ltd.	021-56491756 13512199871	2819742715@qq.com	China	3994	55
Shanghai yirong biology science and technology co., ltd	18049974220	3060526242@qq.com	China	999	60
Wuhan Haizheng Industry & Trade Development Co. Ltd	027-8866 0053/88660577/88660578		China	1070	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
INTATRADE GmbH	66
Alfa Aesar	84
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
ChangZhou SIDU chemical Co., Ltd.	62
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
Shanghai Sphchem Co., Ltd.	55
Shanghai yirong biology science and technology co., ltd	60
Wuhan Haizheng Industry & Trade Development Co. Ltd	55

View Latest Price from 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-15	2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi 7355-55-7			99.42%	10g	TargetMol Chemicals Inc.
2022-09-12	2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine 7355-55-7		1G	98%min	50kg/month	Shanghai Rlavie Technology Co ltd
2019-07-06	2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine 7355-55-7	$8.80	1KG	97%-99%	100kg	Career Henan Chemical Co

2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
7355-55-7
$0.00
99.42%
TargetMol Chemicals Inc.

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine
7355-55-7
98%min
Shanghai Rlavie Technology Co ltd

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine
7355-55-7
$8.80
97%-99%
Career Henan Chemical Co

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine Spectrum

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine(7355-55-7)¹HNMR

7355-55-7 (2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine) Related Search:

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2'-Deoxy-L-guanosine 7-DEAZAGUANOSINE Isopropyl 2-amino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate BIOTIN-11-DDGTP 2-Amino-4-methoxy-7-(beta-D-2-deoxyribofuranosyl)pyrrolo[2,3-d]pyrimidine

N2-(Dimethylaminomethylidene)-7-deaza-2'-deoxyguanosine 5'-O-(Dimethoxytrityl)-N2-(dimethylaminomethylidene)-7-deaza-2'-deoxyguanosi ne 7-Deaza-2'-deoxyguanosine 5'-O-(4,4'-Dimethoxytrityl)-N2-dimethylaminomethylene-7-deaza-2'-deoxyguanosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite 7-Deaza-beta-D-2',3'-dideoxyguanosine

2-Amino-4-methoxy-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid 7-Deazaguanosine, [8-3H(N)]- 2-Amino-6-ethyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

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deazaguanine 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine 7-Deazaguanine 2-amino-1H-pyrrolo[2,3-d]pyrimidin-4-ol 2-Amino-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one 2-AMINO-4-HYDROXY-7H-PYRROLO[2,3-DPYRIMIDINE] 2-AMINO-4-HYDROXYPYRROLO-[2,3-D]PYRIMIDINE 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-1,7-dihydro- (9CI) 2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidine 2-amino-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one Aids045539 Aids-045539 2-Amino-3,7-dihydro-4Hpyrrolo[2,3-d]pyrimidin-4-one 2-aMino-3H,4H,7H-pyrrolo[2,3-d]pyriMidin-4-one 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-1,7-dihydro- 2-amino-1,7-dihydropyrrolo[2,3-d]pyrimidin-4-one 2-Amino-7H-pyrrolo[2,3-d]pyrimidin-4-ol 95+% 2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi OK-B-01044 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-3,7-dihydro- 7-Deazaguanine,97% 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine USP/EP/BP 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidin Propranolol Impurity 12 2-AMINO-3,7-DIHYDRO-PYRROLO[2,3-D]PYRIMIDIN-4-ONE 2-AMINO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-OL 7-DEAZAGUANINE 7355-55-7 Enzyme Inhibitors Enzymes, Inhibitors, and Substrates Enzyme Inhibitors by Type Substrate Analogs Biochemicals and Reagents BioChemical PYRIMIDINE AMINEPRIMARY Heterocyclic Series Heterocyclic Compounds Bases & Related Reagents Heterocycles Intermediates Nucleotides