3-Carboxy-5-nitrophenylboronic acid
- CAS No.
- 101084-81-5
- Chemical Name:
- 3-Carboxy-5-nitrophenylboronic acid
- Synonyms
- 3-BORONO-5-NITROBENZOIC ACID;AKOS BRN-0156;CAS:101084-81-5;RARECHEM AH PB 0071;3-Carboxy-5-nitrophe;3-CARBOXY-5-NITROBENZOIC ACID;3-Carboxy-5-Nitrophenylboronic;3-Carboxy-5-nitrophenylbor acid;Benzoic acid, 3-borono-5-nitro-;5-Nitro-3-carboxyphenylboronic acid
- CBNumber:
- CB1431069
- Molecular Formula:
- C7H6BNO6
- Molecular Weight:
- 210.94
- MDL Number:
- MFCD00757433
- MOL File:
- 101084-81-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 229°C(lit.) |
|---|---|
| Boiling point | 502.6±60.0 °C(Predicted) |
| Density | 1.62±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 3.49±0.10(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| InChI | 1S/C7H6BNO6/c10-7(11)4-1-5(8(12)13)3-6(2-4)9(14)15/h1-3,12-13H,(H,10,11) |
| InChIKey | WNIFCLWDGNHGMX-UHFFFAOYSA-N |
| SMILES | OB(O)c1cc(cc(c1)[N+]([O-])=O)C(O)=O |
| CAS DataBase Reference | 101084-81-5(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Carboxy-5-nitrophenylboronic acid price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 721042 | 3-Carboxy-5-nitrophenylboronic acid | 101084-81-5 | 5g | $153 | 2026-04-30 | Buy |
| Sigma-Aldrich | 721042 | 3-Carboxy-5-nitrophenylboronic acid | 101084-81-5 | 1g | $77 | 2023-06-20 | Buy |
| TCI Chemical | C2385 | 3-Carboxy-5-nitrophenylboronic Acid (contains varying amounts of Anhydride) | 101084-81-5 | 1g | $118 | 2026-04-30 | Buy |
| TCI Chemical | C2385 | 3-Carboxy-5-nitrophenylboronic Acid (contains varying amounts of Anhydride) | 101084-81-5 | 5g | $353 | 2026-04-30 | Buy |
| Biosynth | FC37899 | 3-Carboxy-5-nitrophenylboronic acid | 101084-81-5 | 10g | $243.3 | 2026-06-04 | Buy |
3-Carboxy-5-nitrophenylboronic acid Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
Reactant for:
- Copper-catalyzed chlorination
- Parallel solid-phase synthesis of azabicyclooctylidenemethylbenzamides as μ- and d-opioid agonists
Used for:
- Immobilization of glucose oxidase and acetylcholinesterase on boronic acid-activated silica surfaces
Uses
suzuki reaction
Synthesis
25487-66-5
101084-81-5
The general procedure for the synthesis of 3-carboxy-5-nitrophenylboronic acid from 3-carboxyphenylboronic acid is as follows: first, 7.5 g of 3-carboxyphenylboronic acid (45.2 mmol) was mixed with 25 ml of concentrated sulphuric acid, and 25 ml of fuming nitric acid was slowly added under rapid stirring conditions while cooling using an ice water bath. The reaction mixture was stirred for 15 min, then the ice water bath was removed and the reaction continued to be stirred for 15 min. Subsequently, the reaction solution was poured into ice water to produce a precipitate, which was filtered and then the precipitate was washed with ice water for 5 times, and finally 6.01 g of 3-nitro-5-carboxyphenylboronic acid as a white solid was obtained by aqueous recrystallization in 63.0% yield. Next, 1.50 g of 3-carboxy-5-nitrophenylboronic acid (7.1 mmol) was dissolved in 20 ml of methanol, and 2 g of 10% Pd/C catalyst was added in a 50 ml three-necked flask for a catalytic hydrogenolysis reaction for 6 hours. After completion of the reaction, the Pd/C catalyst was removed by filtration and the filtrate was evaporated to dryness to give 1.25 g of 3-amino-5-carboxyphenylboronic acid as a white powdery solid in 97.1% yield.
References
[1] Patent: CN103497211, 2016, B. Location in patent: Paragraph 0190
[2] Organic Preparations and Procedures International, 1991, vol. 23, # 6, p. 729 - 734
[3] Journal of the American Chemical Society, 1959, vol. 81, p. 3017
[4] Arkiv foer Kemi, 1957, vol. 10, p. 497,503
3-Carboxy-5-nitrophenylboronic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 |
View Lastest Price from 3-Carboxy-5-nitrophenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3-Carboxy-5-nitrophenylboronic acid
101084-81-5
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-03-20 | 3-Carboxy-5-nitrophenylboronic acid
101084-81-5
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2020-02-26 | 3-Carboxy-5-nitrophenylboronic acid
101084-81-5
|
1KG | 99.0%+ | 100 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 3-Carboxy-5-nitrophenylboronic acid
101084-81-5
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-Carboxy-5-nitrophenylboronic acid
101084-81-5
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-Carboxy-5-nitrophenylboronic acid
101084-81-5
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
