3-Nitroacetophenone
- CAS No.
- 121-89-1
- Chemical Name:
- 3-Nitroacetophenone
- Synonyms
- 1-(3-NITROPHENYL)ETHANONE;M-NITROACETOPHENONE;3'-nitroacetophenone;(3-nitrophenyl)methylketone;usafma-1;USAF ma-1;AKOS 233-65;AURORA 14018;AKOS BBS-00003220;3-Nitroacetofenon
- CBNumber:
- CB4400448
- Molecular Formula:
- C8H7NO3
- Molecular Weight:
- 165.15
- MDL Number:
- MFCD00007259
- MOL File:
- 121-89-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 76-78 °C(lit.) |
|---|---|
| Boiling point | 202 °C(lit.) |
| Density | 1.3450 (rough estimate) |
| vapor pressure | 0.32Pa at 25℃ |
| refractive index | 1.5468 (estimate) |
| Flash point | 202°C |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| color | Yellow to yellow-green |
| Odor | Odorless |
| Water Solubility | <0.01 g/100 mL at 20 ºC |
| BRN | 743002 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| InChI | 1S/C8H7NO3/c1-6(10)7-3-2-4-8(5-7)9(11)12/h2-5H,1H3 |
| InChIKey | ARKIFHPFTHVKDT-UHFFFAOYSA-N |
| SMILES | CC(=O)c1cccc(c1)[N+]([O-])=O |
| LogP | 1.42 |
| EWG's Food Scores | 1 |
| FDA UNII | SU4B5T763F |
| NIST Chemistry Reference | 3-Nitroacetophenone(121-89-1) |
| EPA Substance Registry System | 3-Nitroacetophenone (121-89-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 21 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AM9625000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29147090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Aquatic Chronic 3 | |||||||||
| Hazardous Substances Data | 121-89-1(Hazardous Substances Data) | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,200mg/kg (200mg/kg),National Technical Information Service. Vol. AD277-689, | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3-Nitroacetophenone price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 72610 | 3′-Nitroacetophenone purum, ≥98.0% (GC) | 121-89-1 | 100g | $38.9 | 2026-04-30 | Buy |
| TCI Chemical | N0109 | 3'-Nitroacetophenone >98.0%(GC) | 121-89-1 | 25g | $22 | 2026-04-30 | Buy |
| TCI Chemical | N0109 | 3'-Nitroacetophenone >98.0%(GC) | 121-89-1 | 100g | $51 | 2026-04-30 | Buy |
| Usbiological | 284947 | 3-Nitroacetophenone Asreported | 121-89-1 | 500g | $360 | 2026-06-03 | Buy |
| Usbiological | 284947 | 3-Nitroacetophenone Asreported | 121-89-1 | 1kg | $505 | 2026-06-03 | Buy |
3-Nitroacetophenone Chemical Properties, Uses, Production
Chemical Properties
white to light beige crystalline powder or yellow needle-like crystals. soluble in hot water and ether, slightly soluble in ethanol. can be volatile with water vapor.
Uses
3''-Nitroacetophenone is used as a reactant in the synthesis of fluorine based aminothiazoles with antimicrobial activity.
Uses
3′-Nitroacetophenone can undergo high hydrostatic pressure-assisted reduction with Ni–Al alloy in water to form 1-(3-aminophenyl)ethanol.
Preparation
3-Nitroacetophenone is synthesized from acetophenone by nitration.
Synthesis of 3-nitroacetophenone
Production Methods
Acetophenone is carefully dissolved in concentrated sulfuric acid at 0 ℃, and mixed acid is added slowly below 0 ℃. The crude product is precipitated by quenching into ice, filtered, and washed acid free. Purification, mainly from the ortho isomer, is achieved by recrystallization from ethanol with significant lowering of the overall yield to ca. 55 %.
General Description
3-nitroacetophenone is a light beige powder. It is an anthropogenic compound which is used as a synthetic intermediate in the production of dyes and other organic compounds. (NTP, 1992)
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A nitrated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.
Fire Hazard
Flash point data for 3-Nitroacetophenone are not available, however 3-Nitroacetophenone is probably combustible.
Purification Methods
Distil the ketone in steam and crystallise it from EtOH. [Beilstein 7 IV 656.]
References
[1] Chemical Communications, 2017, vol. 53, # 51, p. 6926 - 6929
[2] Journal of Organometallic Chemistry, 2017, vol. 851, p. 46 - 51
[3] Journal of Organometallic Chemistry, 2015, vol. 799-800, p. 122 - 127
[4] Chemische Berichte, 1913, vol. 46, p. 3733
[5] Organometallics, 2013, vol. 32, # 9, p. 2814 - 2826
3-Nitroacetophenone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Siyan Biological Technology Co., Ltd. | 021-50908862，442785678，326799392 18721037013 | siyansales@126.com | China | 9612 | 58 |
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| CHANGZHOU HONGYU CHEMICAL CO.,LTD | 0519-89996110 13813691203 | 1031106541@qq.com | China | 182 | 58 |
| Suzhou Zejun Biotechnology Co., Ltd. | 13814894981 | 749428581@qq.com | China | 238 | 58 |
| Tianjin Zhongxin Chemtech Co., Ltd. | 022-66880623 | sales@tjzxchem.com | China | 612 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Chang Zhou Chemistar Chemistry Technology Co.,Ltd | +86 (519) 8689-6136 | kr@krchemistar.com | China | 181 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from 3-Nitroacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3-Nitroacetophenone
121-89-1
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | 3-Nitroacetophenone
121-89-1
|
$1.90 | 1KG | 99% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2025-06-27 | 3-Nitroacetophenone
121-89-1
|
50KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 3-Nitroacetophenone
121-89-1
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-Nitroacetophenone
121-89-1
- $1.90
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 3-Nitroacetophenone
121-89-1
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
