N-pyridin-3-ylthiophene-2-carboxamide
- CAS No.
- 62289-81-0
- Chemical Name:
- N-pyridin-3-ylthiophene-2-carboxamide
- Synonyms
- SW-106065;MPNST Inhibitor, Cpd21;SW106065, 10 mM in DMSO;N-pyridin-3-ylthiophene-2-carboxamide;2-Thiophenecarboxamide, N-3-pyridinyl-;cell,SW 106065,cdk4,Inhibitor,MPNST,cycle,ATP,anticancer,cdk6,cyclin,SW106065,Apoptosis,inhibit
- CBNumber:
- CB14316832
- Molecular Formula:
- C10H8N2OS
- Molecular Weight:
- 204.25
- MDL Number:
- MFCD00469725
- MOL File:
- 62289-81-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
N-pyridin-3-ylthiophene-2-carboxamide Chemical Properties,Uses,Production
Uses
SW106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST). SW106065 inhibits ATP consumption of sMPNST and other models of MPNST with an EC50 of 1 μM. SW106065 can be used for MPNST research[1].
Biological Activity
Cell permeable: yes', 'Reversible: yes
in vivo
SW106065 (Cpd21; 40 mg/kg; intraperitoneal injection; twice per day for 4 weeks) treatment can be delivered to mice in concentrations to sufficiently penetrate sMPNST tissue, and inhibit tumor development[1].
| Animal Model: | NCR-nu/nu female mice (6-7 week old) injected with MPNST cells[1] |
| Dosage: | 40 mg/kg |
| Administration: | Intraperitoneal injection; twice per day for 4 weeks |
| Result: | Reduced MPNST burden in a mouse allograft model. |
References
[1] Vincent Chau, et al. Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors. Cancer Res. 2014 Jan 15;74(2):586-97. DOI:10.1158/0008-5472.CAN-13-1934
N-pyridin-3-ylthiophene-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-pyridin-3-ylthiophene-2-carboxamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Alinda Chemical Ltd. | +7 (495) 672-17-08 | sale@alinda.ru | Russia | 68136 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4611 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6439 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
