2-Pyridylthiourea
- CAS No.
- 14294-11-2
- Chemical Name:
- 2-Pyridylthiourea
- Synonyms
- 1-PYRIDIN-2-YLTHIOUREA;AKOS BBS-00007311;2-Pyridylthiourea;N-(2-Pyridyl)thiourea;N-PYRIDIN-2-YLTHIOUREA;N-2-Pyridinyl-Thiourea;Thiourea,N-2-pyridinyl-;1-(2-PYRIDYL)-2-THIOUREA;N-(2-Pyridyl)thiourea, 98%;1-(Pyridin-2-yl)thiourea 98%
- CBNumber:
- CB1445909
- Molecular Formula:
- C6H7N3S
- Molecular Weight:
- 153.2
- MDL Number:
- MFCD00041227
- MOL File:
- 14294-11-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 148-150°C |
|---|---|
| Boiling point | 298.7±32.0 °C(Predicted) |
| Density | 1.382±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 12.00±0.70(Predicted) |
| color | White to Light yellow |
| BRN | 117849 |
| InChI | InChI=1S/C6H7N3S/c7-6(10)9-5-3-1-2-4-8-5/h1-4H,(H3,7,8,9,10) |
| InChIKey | SLUHLANJIVXTRQ-UHFFFAOYSA-N |
| SMILES | N(C1=NC=CC=C1)C(N)=S |
| CAS DataBase Reference | 14294-11-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310-P305+P351+P338-P330-P501a-P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | 2811 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
2-Pyridylthiourea price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | P2272 | (2-Pyridyl)thiourea >98.0%(HPLC)(T) | 14294-11-2 | 5g | $73 | 2026-04-30 | Buy |
| TCI Chemical | P2272 | (2-Pyridyl)thiourea >98.0%(HPLC)(T) | 14294-11-2 | 25g | $230 | 2026-04-30 | Buy |
| Usbiological | 419137 | 2-Pyridylthiourea | 14294-11-2 | 250mg | $312 | 2026-06-03 | Buy |
| Usbiological | 419137 | 2-Pyridylthiourea | 14294-11-2 | 1g | $403 | 2026-06-03 | Buy |
| Usbiological | 288190 | N-(2-Pyridinyl)thiourea Asreported | 14294-11-2 | 2g | $333 | 2026-06-03 | Buy |
2-Pyridylthiourea Chemical Properties, Uses, Production
Uses
2-Pyridylthiourea is an intermediate used to prepare disubstituted thiazoles as potential antibacterial and antiinflammatory agents via condensation of phenacyl bromide with thioureas and thiosemicarbazones. It is also used in the synthesis of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors.
Synthesis
4921-86-2
14294-11-2
The general procedure for the synthesis of 1-(2-pyridyl)thiourea from 1-benzoyl-3-(2-pyridyl)-2-thiourea was as follows: N-(pyridin-2-ylthiocarbonyl)benzamide (2.3 g, 8.95 mmol) was suspended in a 10% aqueous NaOH solution (10.4 mL, 26 mmol) and stirred for 10 min at room temperature, then heated to reflux to continue the reaction for 10 minutes. Upon completion of the reaction, the mixture was cooled to 0 °C, diluted with 100 mL of water and subsequently extracted with ethyl acetate (3 × 150 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give the crude product 1-(2-pyridyl)thiourea (1.2 g). Mass spectrometry (electrospray ionization) m/z (M+H) confirmed the product.
References
[1] Synthesis, 1988, # 6, p. 456 - 459
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 14, p. 3706 - 3712
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 2, p. 634 - 639
[4] Journal of the Chemical Society, 1955, p. 803
[5] Journal of Organic Chemistry USSR (English Translation), 1991, vol. 27, # 1.2, p. 177 - 182
2-Pyridylthiourea Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangxi Boye Medical Technology Co., Ltd | 027-18971341812/18971341812 18971341812 | anikay@boyechemicals.com | China | 480 | 58 |
| Jiangxi Boye Medical Technology Co., Ltd | 15387090420 15387090420; | 2684361091@qq.com | China | 468 | 58 |
| Changsha Luxing Bio-Chem Technology Co., Ltd. | 0731-88827538 15574813303 | luxingbc@126.com | China | 1975 | 65 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
View Latest Price from 2-Pyridylthiourea manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | 2-PYRIDYLTHIOUREA
14294-11-2
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-06 | 2-PYRIDYLTHIOUREA
14294-11-2
|
$500.00 | 1KG | 98% | 1ton | Career Henan Chemical Co |
-
- 2-PYRIDYLTHIOUREA
14294-11-2
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-PYRIDYLTHIOUREA
14294-11-2
- $500.00
- 98%
- Career Henan Chemical Co
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