N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea
- CAS No.
- 249889-64-3
- Chemical Name:
- N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea
- Synonyms
- CS-1473;SB 334867;SB 334867A;SB334867 HCl;Zinc00008794;SB-334867 (SB 334867A;SB-334867（249889-64-3）;SB-334867 hydrochloride;SB 334867 hydrochloride NEW;SB 334867A; SB334867; SB 334867
- CBNumber:
- CB1458943
- Molecular Formula:
- C17H13N5O2
- Molecular Weight:
- 319.32
- MDL Number:
- MFCD06411602
- MOL File:
- 249889-64-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BS165496 | SB 334867 | 249889-64-3 | 10mg | $150 | 2026-06-04 | Buy |
| Biosynth | BS165496 | SB 334867 | 249889-64-3 | 50mg | $417.5 | 2026-06-04 | Buy |
| ChemScene | CS-1924 | SB-334867 99.08% | 249889-64-3 | 5mg | $100 | 2026-06-04 | Buy |
| ChemScene | CS-1924 | SB-334867 99.08% | 249889-64-3 | 10mg | $171 | 2026-06-04 | Buy |
| ChemScene | CS-1924 | SB-334867 99.08% | 249889-64-3 | 25mg | $330 | 2026-06-04 | Buy |
N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea Chemical Properties, Uses, Production
Uses
SB 334867 is an orexin-1-receptor antagonist. An important ligand for the study of the orexin 1 (OX1) receptor due to its high OX1/OX2 selectivity and bioavailability.
Definition
ChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative.
Biological Activity
Selective non-peptide orexin OX 1 receptor antagonist. pK b values are 7.2 and < 5 for inhibition of intracellular Ca 2+ release in CHO cells expressing human OX 1 and OX 2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo .
in vivo
SB-334867 (intraperitoneal injection; 20 mg/kg; 20 days) administers 15 min before morphine injection can significantly decrease the effect of the morphine challenge dose in mice in comparison with the sporadically morphine-treated group[2].SB334867 (intraperitoneal injection; 3, 10 and 30 mg/kg) significantly reduces ethanol intake relative to vehicle and does not effect water consumption in female P rats[3].SB334867 (intraperitoneal injection; 3, 10 and 30 mg/kg) reduces ethanol consumption at the 30 mg/kg dose, high dose suppresses sucrose intake relative to vehicle, and it results in lower blood ethanol concentrations (BECs) relative to both the 10 and 30 mg/kg doses[3].
| Animal Model: | Male Swiss mice[2] |
| Dosage: | 20mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Inhibited the acquisition of morphine-induced sensitization to locomotor activity of mice. |
| Animal Model: | C57BL/6J Mice[3] |
| Dosage: | 3, 10 and 30 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Reduced ethanol consumption, BECs and suppressed sucrose intake in mice. |
IC 50
OX1
References
[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452.
N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1784 | 58 | |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| ShangHai Siyan Biological Technology Co., Ltd. | 021-50908862，442785678，326799392 18721037013 | siyansales@126.com | China | 9612 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
View Latest Price from N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-02 | N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
249889-64-3
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
249889-64-3
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
