JNJ-632
- CAS No.
- 1572510-42-9
- Chemical Name:
- JNJ-632
- Synonyms
- JNJ-632;CS-2776;JNJ-632, 10 mM in DMSO;JNJ-632; JNJ 632; JNJ632;JNJ 632,Inhibitor,inhibit,JNJ632,Hepatitis B virus,HBV,JNJ-632;N-(4-fluoro-3-methylphenyl)-3-[[(3S)-oxolan-3-yl]sulfamoyl]benzamide;N-(4-fluoro-3-methyl-phenyl)-3-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]benzamide;(S)-N-(4-Fluoro-3-methylphenyl)-3-(N-(tetrahydrofuran-3-yl)sulfamoyl)benzamide;N-(4-Fluoro-3-methylphenyl)-3-[[[(3S)-tetrahydro-3-furanyl]amino]sulfonyl]benzamide;Benzamide, N-(4-fluoro-3-methylphenyl)-3-[[[(3S)-tetrahydro-3-furanyl]amino]sulfonyl]-
- CBNumber:
- CB14632433
- Molecular Formula:
- C18H19FN2O4S
- Molecular Weight:
- 378.42
- MDL Number:
- MFCD31692402
- MOL File:
- 1572510-42-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| JNJ-632 ≥98% | 26325 | 1mg | $49 |
| JNJ-632 ≥98% | 26325 | 5mg | $213 |
| JNJ-632 ≥98% | 26325 | 10mg | $376 |
| JNJ-632 ≥98% | 26325 | 25mg | $762 |
| JNJ-632 | 26325 | 1mg | $44 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) | ![]() GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
JNJ-632 price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26325 | JNJ-632 ≥98% | 1572510-42-9 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 26325 | JNJ-632 ≥98% | 1572510-42-9 | 5mg | $213 | 2026-04-30 | Buy |
| Cayman Chemical | 26325 | JNJ-632 ≥98% | 1572510-42-9 | 10mg | $376 | 2026-04-30 | Buy |
| Cayman Chemical | 26325 | JNJ-632 ≥98% | 1572510-42-9 | 25mg | $762 | 2026-04-30 | Buy |
| Cayman Chemical | 26325 | JNJ-632 | 1572510-42-9 | 1mg | $44 | 2024-03-01 | Buy |
JNJ-632 Chemical Properties,Uses,Production
Uses
JNJ-632 is a hepatitis B virus (HBV) capsid assembly modulator (CAM).
in vivo
The single dose PK profile of JNJ-632 is evaluated in C57BL/6 mice following intravenous (iv) and oral (po) administration. JNJ-632 has a moderate plasma clearance of 34 mL/min/kg and a moderate volume of distribution of 1.3 L/kg. The oral bioavailability is 40% following oral administration of 10 mg/kg and 66% following oral administration of 50 mg/kg. JNJ-632 has moderate terminal elimination half-life with t1/2s of 0.42±0.06 h, 1.1±0.67 h, 2.4±2.3 h, and 5.3±0.1 h for 2.5 mg/kg (iv), 10 mg/kg (po), 50 mg/kg (po), and 50 mg/kg (sc).To circumvent the first pass metabolism, JNJ-632 is also dosed subcutaneously at 50 mg/kg in C57BL/6 mice and this results in a concentration in plasma after 24 h of dosing of 102 ng/mL and concentration in liver after 24 h of dosing of 1297 ng/g[1].
References
[1] Vandyck K, et al. Synthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV). J Med Chem. 2018 Jul 26;61(14):6247-6260. DOI:10.1021/acs.jmedchem.8b00654
JNJ-632 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Chemia Biotechnology(Shanghai) Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9949 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
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