SBI-425
- CAS No.
- 1451272-71-1
- Chemical Name:
- SBI-425
- Synonyms
- SBI-425;SBI-425 (SBI425);SBI-425, 10 mM in DMSO;SBI-425,Phosphatase,Inhibitor,SBI425,SBI 425,inhibit;5-(5-Chloro-2-methoxybenzenesulfonamido)pyridine-3-carboxamide;3-Pyridinecarboxamide, 5-[[(5-chloro-2-methoxyphenyl)sulfonyl]amino]-;5-[(5-chloro-2-methoxybenzene)sulfonamido]pyridine-3-carboxamide - [AC80942]
- CBNumber:
- CB14668489
- Molecular Formula:
- C13H12ClN3O4S
- Molecular Weight:
- 341.77
- MDL Number:
- MFCD31652984
- MOL File:
- 1451272-71-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 582.1±60.0 °C(Predicted) |
|---|---|
| Density | 1.509±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble |
| form | A solid |
| pka | 6.21±0.40(Predicted) |
| color | White to off-white |
| InChI | 1S/C13H12ClN3O4S/c1-21-11-3-2-9(14)5-12(11)22(19,20)17-10-4-8(13(15)18)6-16-7-10/h2-7,17H,1H3,(H2,15,18) |
| InChIKey | SBAITEDLNTYIOE-UHFFFAOYSA-N |
| SMILES | [S](=O)(=O)(Nc2cncc(c2)C(=O)N)c1c(ccc(c1)Cl)OC |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SBI-425 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 34626 | SBI-425 ≥98% | 1451272-71-1 | 1mg | $37 | 2026-04-30 | Buy |
| Cayman Chemical | 34626 | SBI-425 ≥98% | 1451272-71-1 | 5mg | $99 | 2026-04-30 | Buy |
| Cayman Chemical | 34626 | SBI-425 ≥98% | 1451272-71-1 | 10mg | $181 | 2026-04-30 | Buy |
| Cayman Chemical | 34626 | SBI-425 ≥98% | 1451272-71-1 | 25mg | $404 | 2026-04-30 | Buy |
| Biosynth | BIC27271 | 5-(5-Chloro-2-methoxybenzenesulfonamido)pyridine-3-carboxamide | 1451272-71-1 | 5mg | $250 | 2026-06-04 | Buy |
SBI-425 Chemical Properties, Uses, Production
Description
SBI-425 is a potent, selective and orally bioavailable compound that robustly inhibits tissue-nonspecific alkaline phosphatase (TNAP) in vivo.
Uses
SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival[1][2].
in vivo
| Compds | SBI-425 |
| Clp (mL/min/kg) | 5.14 |
| Vd (L/kg) | 1.03 |
| Cmax (μg/mL) | 178 |
| AUC (μg*hr/mL) | 848 |
| t1/2 (hr) | 2.3 |
| %F | 58 |
References
[1] Pinkerton AB, et al. Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34. DOI:10.1016/j.bmcl.2017.11.024
[2] Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30(5):824-36. DOI:10.1002/jbmr.2420
[3] Brichacek AL, et al. Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis. Sci Rep. 2019 Dec 11;9(1):18788. DOI:10.1038/s41598-019-55154-2
SBI-425 Preparation Products And Raw materials
Raw materials
Preparation Products
SBI-425 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9711 | 58 |
| Shanghai Yu Ben Biotechnology Co., Ltd. | 021-61350663 15502154572 | 1639466865@qq.com | China | 499 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Jingmo (Xiamen) Biotechnology Co., Ltd | 13621943973; 13621943973 | sales@jamxmpharmatech.com | China | 1191 | 58 |
