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| | SBI-425 Basic information |
| Product Name: | SBI-425 | | Synonyms: | SBI-425;3-Pyridinecarboxamide, 5-[[(5-chloro-2-methoxyphenyl)sulfonyl]amino]-;SBI-425,Phosphatase,Inhibitor,SBI425,SBI 425,inhibit;SBI-425, 10 mM in DMSO;5-(5-Chloro-2-methoxybenzenesulfonamido)pyridine-3-carboxamide;SBI-425 (SBI425);5-[(5-chloro-2-methoxybenzene)sulfonamido]pyridine-3-carboxamide - [AC80942] | | CAS: | 1451272-71-1 | | MF: | C13H12ClN3O4S | | MW: | 341.77 | | EINECS: | | | Product Categories: | | | Mol File: | 1451272-71-1.mol |  |
| | SBI-425 Chemical Properties |
| Boiling point | 582.1±60.0 °C(Predicted) | | density | 1.509±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A solid | | pka | 6.21±0.40(Predicted) | | color | White to off-white | | InChI | 1S/C13H12ClN3O4S/c1-21-11-3-2-9(14)5-12(11)22(19,20)17-10-4-8(13(15)18)6-16-7-10/h2-7,17H,1H3,(H2,15,18) | | InChIKey | SBAITEDLNTYIOE-UHFFFAOYSA-N | | SMILES | [S](=O)(=O)(Nc2cncc(c2)C(=O)N)c1c(ccc(c1)Cl)OC |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | SBI-425 Usage And Synthesis |
| Description | SBI-425 is a potent, selective and orally bioavailable compound that robustly inhibits tissue-nonspecific alkaline phosphatase (TNAP) in vivo. | | Uses | SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival[1][2]. | | in vivo | 1.19 Mouse PK parameters for SBI-425[1]| Compds | SBI-425 | | Clp (mL/min/kg) | 5.14 | | Vd (L/kg) | 1.03 | | Cmax (μg/mL) | 178 | | AUC (μg*hr/mL) | 848 | | t1/2 (hr) | 2.3 | | %F | 58 | |
| | References | [1] Pinkerton AB, et al. Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34. DOI:10.1016/j.bmcl.2017.11.024
[2] Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30(5):824-36. DOI:10.1002/jbmr.2420
[3] Brichacek AL, et al. Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis. Sci Rep. 2019 Dec 11;9(1):18788. DOI:10.1038/s41598-019-55154-2 |
| | SBI-425 Preparation Products And Raw materials |
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