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TC-2153

TC-2153 Structure
TC-2153 structure
CAS No.
1381769-23-8
Chemical Name:
TC-2153
Synonyms
TC-2153;TC-2153 >=95% (HPLC);TC-2153 hydrochloride;8-(Trifluoromethyl)benzo[f][1,2,3,4,5]pentathiepin-6-amine hydrochloride;benzopentathiepin 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride
CBNumber:
CB14668595
Molecular Formula:
C7H5ClF3NS5
Molecular Weight:
355.87
MDL Number:
MFCD28976193
MOL File:
1381769-23-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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TC-2153 Properties

storage temp. -20°C
solubility DMSO: 5mg/mL, clear
form powder
color white to beige
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

TC-2153 price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1299 TC-2153 ≥95% (HPLC) 1381769-23-8 5MG $161 2026-04-30 Buy
Sigma-Aldrich SML1299 TC-2153 ≥95% (HPLC) 1381769-23-8 25MG $637 2026-04-30 Buy
Biosynth GFC76923 TC-2153 hydrochloride 1381769-23-8 100mg $1233 2026-06-04 Buy
Biosynth GFC76923 TC-2153 hydrochloride 1381769-23-8 500mg $2270 2026-06-04 Buy
Biosynth GFC76923 TC-2153 hydrochloride 1381769-23-8 1000mg $3240 2026-06-04 Buy
Product number Packaging Price Buy
SML1299 5MG $161 Buy
SML1299 25MG $637 Buy
GFC76923 100mg $1233 Buy
GFC76923 500mg $2270 Buy
GFC76923 1000mg $3240 Buy

TC-2153 Chemical Properties, Uses, Production

Uses

TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling[1].

Biochem/physiol Actions

TC-2153 is a potent inhibitor of STEP (STriatal-Enriched protein tyrosine Phosphatase) that forms a reversible covalent bond with the catalytic cysteine in STEP. TC-2153 increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B in cell cultures. TC-2153 improves cognitive function in transgenic AD mice.

in vivo

Chronic TC-2153 treatment: TC-2153 (20 mg/kg; i.p.; once daily for 7 d) shows antidepressant-like effect without altering locomotor, exploratory activity and anxiety[1].
Acute TC-2153 treatment: TC-2153 (10 mg/kg and 20 mg/kg; p.o.; single dose) inhibits the functional activity of 5-HT2A receptors in vivo in mice[1].

Animal Model:SPF-state adult mouse males[1]
Dosage:10 mg/kg and 20 mg/kg; with or without 1 mg/kg DOI i.p. at 3 h after final treatment
Administration:Oral gavage or intraperitoneal injection; single dose or once daily for 7 d
Result:Showed antidepressant-like effect in the forced swim test without any adverse side effects on locomotor activity, anxiety, exploration, motor skill and obsessive-compulsive-like behavior.
Both acute and chronic methods inhibited the functional activity of 5-HT2A receptors.

IC 50

5-HT1A Receptor; 5-HT2A Receptor; MAO-A

References

[1] Walters JM, et al. Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity. Epilepsia. 2022 May;63(5):1211-1224. DOI:10.1111/epi.17192

TC-2153 Preparation Products And Raw materials

Raw materials

Preparation Products

TC-2153 Suppliers

Global Suppliers ( 12)
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 sales@rrkchem.com China 57336 58
DC Chemicals 021-58447131 13564518121 doncunbiosci@gmail.com China 618 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2934 58
SuZhou GoodChemTech Co., Ltd 18136139868; 18136139868 jinlun@goodchemtech.cn China 321 58
Aikon International Limited 025-58859352 18651614124 2881516338@qq.com China 9968 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Sigma-Aldrich 80
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
DC Chemicals 58
Energy Chemical 58
TargetMol Chemicals Inc. 58
Shanghai Tachizaki Biomedical Research Center 58
SuZhou GoodChemTech Co., Ltd 58
Aikon International Limited 58
TargetMol Chemicals Inc. 58

View Latest Price from TC-2153 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TC-2153 pictures 2026-07-15 TC-2153
1381769-23-8
 $570.00-1578.00 10g TargetMol Chemicals Inc.
  • TC-2153 pictures
  • TC-2153
    1381769-23-8
  • $570.00-1578.00
  • TargetMol Chemicals Inc.

1381769-23-8 (TC-2153) Related Search:

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Puerarin

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benzopentathiepin 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride TC-2153 TC-2153 >=95% (HPLC) TC-2153 hydrochloride 8-(Trifluoromethyl)benzo[f][1,2,3,4,5]pentathiepin-6-amine hydrochloride 1381769-23-8 C7H4F3NS5ClH