Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Structure
2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione structure
CAS No.
64567-60-8
Chemical Name:
2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
Synonyms
Thalidomide-5-OH;Thalidomide Impurity 2;Thalidomide-5-OH, 10 mM in DMSO;4-Hydroxy thalidomide/Thalidomide-5-OH;Thalidomide 5-Hydroxyisoindoline Impurity;2-(2,6-dioxo-3-piperidyl)-5-hydroxy-isoindoline-1,3-dione;2-(2,6-Dioxo-3-piperidinyl)-5-hydroxy-1,3-isoindolinedione;2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione;2-(2,6-Dioxo-3-piperidinyl)-5-hydroxy-1H-isoindole-1,3(2H)-dione;1H-ISOINDOLE-1,3(2H)-DIONE,2-(2,6-DIOXO-3-PIPERIDINYL)-5-HYDROXY-
CBNumber:
CB14675320
Molecular Formula:
C13H10N2O5
Molecular Weight:
274.23
MDL Number:
MFCD24386541
MOL File:
64567-60-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:49:49
Request For Quotation

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Properties

Melting point 317-318 °C
Boiling point 600.0±45.0 °C(Predicted)
Density 1.611±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO: 62.5 mg/mL (227.91 mM)
pka 7.06±0.20(Predicted)
form Solid
color Gray to brown
InChI InChI=1S/C13H10N2O5/c16-6-1-2-7-8(5-6)13(20)15(12(7)19)9-3-4-10(17)14-11(9)18/h1-2,5,9,16H,3-4H2,(H,14,17,18)
InChIKey LJBQRRQTZUJWRC-UHFFFAOYSA-N
SMILES C1(=O)C2=C(C=C(O)C=C2)C(=O)N1C1CCC(=O)NC1=O
FDA UNII 29V976C3CJ

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D6178 2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione 64567-60-8 1G $87 2026-04-30 Buy
TCI Chemical D6178 2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione 64567-60-8 5G $260 2026-04-30 Buy
Biosynth FH46213 4-Hydroxy thalidomide 64567-60-8 500mg $150 2026-06-04 Buy
Biosynth FH46213 4-Hydroxy thalidomide 64567-60-8 1000mg $150 2026-06-04 Buy
Biosynth FH46213 4-Hydroxy thalidomide 64567-60-8 2000mg $200 2026-06-04 Buy
Product number Packaging Price Buy
D6178 1G $87 Buy
D6178 5G $260 Buy
FH46213 500mg $150 Buy
FH46213 1000mg $150 Buy
FH46213 2000mg $200 Buy

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Chemical Properties, Uses, Production

Uses

Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

Definition

ChEBI: 5-Hydroxythalidomide is a member of phthalimides.

IC 50

Cereblon

References

[1] Megan G Marks, et al. Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation. Biol Pharm Bull. 2002 May;25(5):597-604. DOI:10.1248/bpb.25.597

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Suppliers

Global Suppliers ( 108)
Supplier Tel Email Country ProdList Advantage
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd 0371-88900765 18037465274 3430974218@qq.com China 14171 58
Abosyn 0512-69561983 13914027025 he_qf@medinoah.com China 3000 58
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 7909 65
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9510 58
Zouping Mingxing Chemical Co.,Ltd. 86-13605431940 13605431940 zpmxchemical@126.com China 1490 62
Supplier Advantage
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd 58
Abosyn 58
PharmaBlock Sciences (Nanjing),Inc. 55
Chembest Research Laboratories Limited 61
Energy Chemical 61
Adamas Reagent, Ltd. 59
Accela ChemBio Co.,Ltd. 64
Daicel Chiral Technologies (China)CO.,LTD 65
Shanghai Topbiochem Technology Co., Ltd 58
Zouping Mingxing Chemical Co.,Ltd. 62

View Latest Price from 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione pictures 2026-09-02 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
64567-60-8
 $1.00-8.00 1KG 99% Henan Fengda Chemical Co., Ltd
Thalidomide-5-OH pictures 2026-05-11 Thalidomide-5-OH
64567-60-8
 $29.00 98.94% 10g TargetMol Chemicals Inc.
2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione pictures 2025-04-04 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
64567-60-8
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Spectrum

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione(64567-60-8)1HNMR

64567-60-8 (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) Related Search:

Thalidomide 4-Hydroxy ThalidoMide 1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-hydroxy- 1H-Isoindole-1,3(2H)-dione, 5-hydroxy-2-(1-methyl-2,6-dioxo-3-piperidinyl)- 3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)propanoic acid
1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-5-hydroxy-

1of2

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione 2-(2,6-Dioxo-3-piperidinyl)-5-hydroxy-1H-isoindole-1,3(2H)-dione 1H-ISOINDOLE-1,3(2H)-DIONE,2-(2,6-DIOXO-3-PIPERIDINYL)-5-HYDROXY- Thalidomide Impurity 2 Thalidomide 5-Hydroxyisoindoline Impurity 2-(2,6-Dioxo-3-piperidinyl)-5-hydroxy-1,3-isoindolinedione 4-Hydroxy thalidomide/Thalidomide-5-OH Ligands for E3 Ligase,PROTAC,Inhibitor,Thalidomide5OH,inhibit,CRBN,E3 ligase-recruiting Moiety,Thalidomide,Thalidomide 5 OH 2-(2,6-dioxo-3-piperidyl)-5-hydroxy-isoindoline-1,3-dione Thalidomide-5-OH, 10 mM in DMSO 2-(2,6-dioxo-3-piperidyl)-5-hydroxy-isoindoline-1,3-dione - [D87155] Thalidomide-5-OH 64567-60-8