2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione

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2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione manufacturers

  • Thalidomide-5-OH
  • Thalidomide-5-OH pictures
  • $29.00
  • 2026-05-11
  • CAS:64567-60-8
  • Purity: 98.94%
  • Supply Ability: 10g
2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Basic information
Product Name:2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
Synonyms:2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione;2-(2,6-Dioxo-3-piperidinyl)-5-hydroxy-1H-isoindole-1,3(2H)-dione;1H-ISOINDOLE-1,3(2H)-DIONE,2-(2,6-DIOXO-3-PIPERIDINYL)-5-HYDROXY-;Thalidomide Impurity 2;Thalidomide 5-Hydroxyisoindoline Impurity;2-(2,6-Dioxo-3-piperidinyl)-5-hydroxy-1,3-isoindolinedione;4-Hydroxy thalidomide/Thalidomide-5-OH;Ligands for E3 Ligase,PROTAC,Inhibitor,Thalidomide5OH,inhibit,CRBN,E3 ligase-recruiting Moiety,Thalidomide,Thalidomide 5 OH
CAS:64567-60-8
MF:C13H10N2O5
MW:274.23
EINECS:
Product Categories:
Mol File:64567-60-8.mol
2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Structure
2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Chemical Properties
Melting point 317-318 °C
Boiling point 600.0±45.0 °C(Predicted)
density 1.611±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO: 62.5 mg/mL (227.91 mM)
pka7.06±0.20(Predicted)
form Solid
color Gray to brown
InChIInChI=1S/C13H10N2O5/c16-6-1-2-7-8(5-6)13(20)15(12(7)19)9-3-4-10(17)14-11(9)18/h1-2,5,9,16H,3-4H2,(H,14,17,18)
InChIKeyLJBQRRQTZUJWRC-UHFFFAOYSA-N
SMILESC1(=O)C2=C(C=C(O)C=C2)C(=O)N1C1CCC(=O)NC1=O
Safety Information
MSDS Information
2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Usage And Synthesis
UsesThalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1].
DefinitionChEBI: 5-Hydroxythalidomide is a member of phthalimides.
IC 50Cereblon
References[1] Megan G Marks, et al. Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation. Biol Pharm Bull. 2002 May;25(5):597-604. DOI:10.1248/bpb.25.597
2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Preparation Products And Raw materials
Tag:2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione(64567-60-8) Related Product Information
Thalidomide 4-Hydroxy ThalidoMide 1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-hydroxy- 1H-Isoindole-1,3(2H)-dione, 5-hydroxy-2-(1-methyl-2,6-dioxo-3-piperidinyl)- 3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)propanoic acid 1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-5-hydroxy-