GSK3395879
- CAS No.
- 2215852-91-6
- Chemical Name:
- GSK3395879
- Synonyms
- GSK3395879;GSK-3395879,GSK3395879;Benzonitrile, 4-[[(3S,4R)-1-[[2-cyano-4-(trifluoromethyl)phenyl]sulfonyl]-4-hydroxy-4-(hydroxymethyl)-3-pyrrolidinyl]oxy]-2-fluoro-
- CBNumber:
- CB14676589
- Molecular Formula:
- C20H15F4N3O5S
- Molecular Weight:
- 485.41
- MDL Number:
- MFCD31813660
- MOL File:
- 2215852-91-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
GSK3395879 Chemical Properties, Uses, Production
Description
GSK3395879 is a potent, selective and orally active TRPV4 inhibitor (IC50 = 1 nM), GSK3395879 demonstrated the ability to inhibit TRPV4-mediated pulmonary edema in an in vivo rat model. GSK3395879 is a tool for studying the biology of TRPV4 and an advanced lead for identifying new heart failure medicines.
Uses
GSK3395879 is a selective and orally bioavailable transient receptor potential vanilloid-4 (TRPV4) antagonist with an IC50 of 1 nM for hTRPV4[1].
References
[1] Brnardic EJ, et al. Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4). J Med Chem. 2018 Nov 8;61(21):9738-9755. DOI:10.1021/acs.jmedchem.8b01317
GSK3395879 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK3395879 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Shaanxi Didu Pharmaceutical Co., Ltd. | 029-81124775 17791530730 | 1079@dideu.com | China | 10000 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
View Latest Price from GSK3395879 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | GSK3395879
2215852-91-6
|
$2120.00-3700.00 | 10g | TargetMol Chemicals Inc. |
-
- GSK3395879
2215852-91-6
- $2120.00-3700.00
- TargetMol Chemicals Inc.
