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PIP-199

PIP-199 structure

CAS No.: 622795-76-0

Chemical Name:: PIP-199

Synonyms: PIP-199;Ethyl 4-[(1-hydroxy-2-phenylindol-3-yl)-2-pyridylmethyl]piperazinecarboxylate;ethyl 4-[(1-hydroxy-2-phenyl-1H-indol-3-yl)(pyridin-2-yl)methyl]piperazine-1-carboxylate;PIP-199 ethyl 4-((1-hydroxy-2-phenyl-1H-indol-3-yl)(pyridin-2-yl)methyl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-[(1-hydroxy-2-phenyl-1H-indol-3-yl)-2-pyridinylmethyl]-, ethyl ester

CBNumber:: CB14718650

Molecular Formula:: C27H28N4O3

Molecular Weight:: 456.55

MDL Number:: MFCD04443596

MOL File:: 622795-76-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:37:24

Product description	Number	Pack Size	Price
PIP-199	BA3924	1mg	$160
PIP-199	BA3924	5mg	$578
PIP-199 97%	AA01V58F	1mg	$64
PIP-199 98%byHPLC	AA01V58F	10mg	$567
PIP-199 98%byHPLC	AA01V58F	25mg	$1151

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PIP-199 Properties

Boiling point	655.1±65.0 °C(Predicted)
Density	1.26±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	13.19±0.58(Predicted)
form	Solid
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

PIP-199 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ApexBio Technology	BA3924	PIP-199	622795-76-0	1mg	$160	2026-05-06	Buy
ApexBio Technology	BA3924	PIP-199	622795-76-0	5mg	$578	2026-05-06	Buy
aablocks	AA01V58F	PIP-199 97%	622795-76-0	1mg	$64	2026-05-31	Buy
aablocks	AA01V58F	PIP-199 98%byHPLC	622795-76-0	10mg	$567	2026-05-31	Buy
aablocks	AA01V58F	PIP-199 98%byHPLC	622795-76-0	25mg	$1151	2026-05-31	Buy

Product number	Packaging	Price	Buy
BA3924	1mg	$160	Buy
BA3924	5mg	$578	Buy
AA01V58F	1mg	$64	Buy
AA01V58F	10mg	$567	Buy
AA01V58F	25mg	$1151	Buy

PIP-199 Chemical Properties,Uses,Production

Uses

PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics[1].

Biological Activity

PIP-199 is a selective inhibitor of the RecQ-mediated RMI core complex/MM2 interaction of genomically unstable proteins with IC50 of 36 μM. PIP-199 can be used to sensitize resistant tumors to DNA cross-linking chemotherapeutics.

in vitro

MM2 is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM).
Induction of the Fanconi anemia (FA) DNA repair pathway is a common mechanism by which tumors evolve resistance to DNA crosslinking chemotherapies.
Proper execution of the FA pathway requires interaction between the FANCM and the RMI complex, and mutations that disrupt FANCM/RMI interactions sensitize cells to DNA crosslinking agents.

target

IC50: 36 μM (RMI core complex/MM2 interaction)

References

[1] Andrew F. Voter, et al. A high throughput screening strategy to identify protein-protein interaction inhibitors that block the Fanconi anemia DNA repair pathway. J Biomol Screen. 2016 Jul; 21(6): 626–633. DOI:10.1177/1087057116635503

PIP-199 Preparation Products And Raw materials

Raw materials

Preparation Products

PIP-199 Suppliers

Global( 16)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4857	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9683	58
Shanghai Yu Ben Biotechnology Co., Ltd.	021-61350663 15502154572	1639466865@qq.com	China	499	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	4276	58
cjbscvictory	13348960310 13348960310	3003867561@qq.com	China	10233	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	27066	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	024-88590548 18698872706	757984502@qq.com	China	960	58
Zibo Hangyu Biotechnology Development Co., Ltd	13053322091 13053322091	admin@mopaikeji.com	China	1612	58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.	13761987713; 13761987713	hxzheng@sunwaypharm.cn	China	9905	58

Supplier	Advantage
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai Chaolan Chemical Technology Center	58
Shanghai Yu Ben Biotechnology Co., Ltd.	58
ShangHai ChuanQian Chemcial Technique Centre	58
cjbscvictory	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.	58

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PHOSPHORAMIDEMUSTARD

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PIP-199 PIP-199 ethyl 4-((1-hydroxy-2-phenyl-1H-indol-3-yl)(pyridin-2-yl)methyl)piperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-[(1-hydroxy-2-phenyl-1H-indol-3-yl)-2-pyridinylmethyl]-, ethyl ester ethyl 4-[(1-hydroxy-2-phenyl-1H-indol-3-yl)(pyridin-2-yl)methyl]piperazine-1-carboxylate Ethyl 4-[(1-hydroxy-2-phenylindol-3-yl)-2-pyridylmethyl]piperazinecarboxylate 622795-76-0