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(S)-4-Hydroxy-2-pyrrolidinone

(S)-4-Hydroxy-2-pyrrolidinone structure

CAS No.: 68108-18-9

Chemical Name:: (S)-4-Hydroxy-2-pyrrolidinone

Synonyms: SHPD;OxiracetaM iMpurity A;Oxiracetam Impurity 9;Oxiracetam impurity H;Oxiracetam Impurity N;Busulfan Impurity1706;Oxiracetam impurities1718;4-HYDROXY-PYRROLIDIN-2-ONE;(S)-4-HYDROXY-2-PYRROLIDONE;(s)-β-hydroxy-γ-butyrolactam

CBNumber:: CB1474345

Molecular Formula:: C4H7NO2

Molecular Weight:: 101.1

MDL Number:: MFCD00273370

MOL File:: 68108-18-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:37:54

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(S)-4-Hydroxy-2-pyrrolidinone Properties

Melting point	156-159 °C (lit.)
alpha	-41 º (c=% in ethanol)
Boiling point	363.6±35.0 °C(Predicted)
Density	1.292±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Water Solubility	Slightly soluble in water
pka	13.62±0.20(Predicted)
form	Solid
color	White to off-white
optical activity	[α]23/D 43°, c = 1 in ethanol
BRN	1524192
InChI	1S/C4H7NO2/c6-3-1-4(7)5-2-3/h3,6H,1-2H2,(H,5,7)/t3-/m0/s1
InChIKey	IOGISYQVOGVIEU-VKHMYHEASA-N
SMILES	O[C@@H]1CNC(=O)C1
CAS DataBase Reference	68108-18-9(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS05

Signal word

Warning

Hazard statements

H315-H319-H302-H318

Precautionary statements

P280i-P301+P312a-P305+P351+P338-P310a-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

22-41

Safety Statements

22-24/25-36-26

WGK Germany

HS Code

29349990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1

NFPA 704

	1
2		0

(S)-4-Hydroxy-2-pyrrolidinone price More Price(71)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	479179	(S)-(?)-4-Hydroxy-2-pyrrolidinone 97%	68108-18-9	5g	$235	2026-04-30	Buy
Sigma-Aldrich	479179	(S)-(?)-4-Hydroxy-2-pyrrolidinone 97%	68108-18-9	1g	$52.5	2023-06-20	Buy
TCI Chemical	H1368	(S)-(-)-4-Hydroxy-2-pyrrolidone >98.0%(GC)	68108-18-9	1g	$184	2026-04-30	Buy
Usbiological	465113	S-(-)-4-Hydroxy-2-pyrrolidinone	68108-18-9	1g	$432	2026-06-03	Buy
AstaTech	62394	(S)-4-HYDROXY-2-PYRROLIDINONE 97%	68108-18-9	1G	$28	2026-04-30	Buy

Product number	Packaging	Price	Buy
479179	5g	$235	Buy
479179	1g	$52.5	Buy
H1368	1g	$184	Buy
465113	1g	$432	Buy
62394	1G	$28	Buy

(S)-4-Hydroxy-2-pyrrolidinone Chemical Properties,Uses,Production

Chemical Properties

White crystal

Uses

The (S)-enantiomer intermediate in the preparation of Oxiracetam

Uses

(S)-()-4-Hydroxy-2-pyrrolidinone can be used as a starting material in the preparation of:

Biologically significant pyrrolo[1,2:1′,2′]azepino[5,6-b]indole derivatives.
Substituted azepanes by reacting with various aldehydes via photochemical [5+2] cycloaddition.

General Description

4-Hydroxy-2-pyrrolidinone is an important building block found in many bioactive compounds like streptopyrrolidine. It can be used as an intermediate in the synthesis of various γ-amino acids (GABA) and substituted 2-pyrrolidinones like cynometrine and cynodine.

Synthesis

10.1 g (100 mmol) of 2-oxiranylacetamide, CuI 0.95 g (5 mmol), cesium carbonate 2 g (200 mmol) was added to 150 ml of ammonia in a saturated solution of methanol, 55 for stirring reaction for 8 h, the reaction solution was concentrated under reduced pressure, 100 ml of water was added, dichloromethane extraction three times, saturated saline washed three times, the phase of ethyl acetate was concentrated under reduced pressure, and petroleum ether recrystallization to obtain (S)-(-)-4-hydroxy-2-pyrrolidinone 8.71g, yield 86.3%, HPLC purity 99.42% (area normalization method), ee value 99.67%.

(S)-4-Hydroxy-2-pyrrolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-4-Hydroxy-2-pyrrolidinone Suppliers

Global( 274)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59
Accela ChemBio Co.,Ltd.	64

View Lastest Price from (S)-4-Hydroxy-2-pyrrolidinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	(S)-4-Hydroxy-2-pyrrolidinone 68108-18-9	$3.00-9.00		99%		ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2025-04-04	(S)-4-Hydroxy-2-pyrrolidinone 68108-18-9		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-05-08	4-Hydroxy-2-pyrrolidone 68108-18-9	$2800.00	1Kg	98	500 Kg	R&D Scientific Inc.

(S)-4-Hydroxy-2-pyrrolidinone
68108-18-9
$3.00-9.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

(S)-4-Hydroxy-2-pyrrolidinone
68108-18-9
98%
Henan Aochuang Chemical Co.,Ltd.

4-Hydroxy-2-pyrrolidone
68108-18-9
$2800.00
98
R&D Scientific Inc.

(S)-4-Hydroxy-2-pyrrolidinone Spectrum

(S)-4-Hydroxy-2-pyrrolidinone(68108-18-9)¹HNMR (S)-4-Hydroxy-2-pyrrolidinone(68108-18-9)IR

68108-18-9((S)-4-Hydroxy-2-pyrrolidinone)Related Search:

N-Vinyl-2-pyrrolidone CHLOROPHOSPHONAZO III 2-Pyrrolidinone N-Methyl-2-pyrrolidone Povidone iodine

4-hydroxypyrrolidin-2-one OxiracetaM Related CoMpound 2 Oxiracetam Related Compound 7 Oxiracetam 2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)acetaMide

Oxiracetam Related Compound 8 methyl 4-hydroxy-2-oxopyrrolidine-1-acetate 2-[(carbamoylmethyl)amino]acetamide Oxiracetam Related Compound 5 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid

(4S)-4-hydroxy-2-oxo-1-Pyrrolidineacetic acid Methyl ester Polyvinylpyrrolidone ethyl 4-hydroxy-2-oxopyrrolidine-1-acetate

1of4

2-PYRROLIDINONE, 4-HYDROXY-, (S) 2-PYRROLIDINONE, 4-HYDROXY-, (4S)- (4S)-4-HYDROXYPYRROLIDIN-2-ONE 4-HYDROXY-PYRROLIDIN-2-ONE (s)-(-)-β-hydroxy-γ-butyrolactam (s)-β-hydroxy-γ-butyrolactam (S)-(-)-4-HYDROXY-2-PYRROLIDINONE (S)-(+)-4-HYDROXY-2-PYRROLIDINONE (S)-4-HYDROXY-2-PYRROLIDINONE (S)-4-HYDROXY-2-PYRROLIDONE (S)-4-HYDROXY-PYRROLIDINE-2-ONE SHPD (S)-BETA-HYDROXY-GAMMA-BUTYROLACTAM (S)-(-)-4-Hydroxy-2-pyrrolinone (4S)-4-hydroxy-2-pyrrolidone (S)-4-Hydroxy-pyrrolidin-2-one (4S)-(-)-4-Hydroxy-2-oxopyrrolidine, (4S)-(-)-beta-Hydroxy-gamma-butyrolactam (4S)-4-Hydroxy-2-pyrrolidinone OxiracetaM iMpurity A Oxiracetam Impurity 9 (S)-4-Mercapto-2-pyrrolidone Oxiracetam Impurity A ((S)-4-Hydroxy-2-pyrrolidinone) (S)-(-)-4-Hydroxy-2-pyrrolidinone 97% (S)-4-Hydroxy-2-pyrrolidone,99%e.e. Oxiracetam impurity H Oxiracetam Impurity N (S)-(-)-4-Hydroxy-2-pyrrolidone> Busulfan Impurity1706 Oxiracetam impurities1718 (S)-(-)-4-Hydroxy-2-pyrrolidinone (Oxiracetam Impurity) (S)-(?)-4-Hydroxy-2-pyrrolidinone (S)-4-hydroxypyrrolidin-2-one, 98%min 68108-18-9 C4H7NO2 Heterocyclic Building Blocks Pyrrolidines Chiral Building Blocks Asymmetric Synthesis Amines Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Chiral Pyrrolidinone derivatives Drug Intermediates