ChemicalBook >> CAS DataBase List >>(S)-4-Hydroxy-2-pyrrolidinone
(S)-4-Hydroxy-2-pyrrolidinone
- CAS No.
- 68108-18-9
- Chemical Name:
- (S)-4-Hydroxy-2-pyrrolidinone
- Synonyms
- SHPD;OxiracetaM iMpurity A;Oxiracetam Impurity 9;Oxiracetam impurity H;Oxiracetam Impurity N;Busulfan Impurity1706;Oxiracetam impurities1718;4-HYDROXY-PYRROLIDIN-2-ONE;(S)-4-HYDROXY-2-PYRROLIDONE;(s)-β-hydroxy-γ-butyrolactam
- CBNumber:
- CB1474345
- Molecular Formula:
- C4H7NO2
- Molecular Weight:
- 101.1
- MDL Number:
- MFCD00273370
- MOL File:
- 68108-18-9.mol
Last updated:2026-01-13 11:14:12
| Product description | Number | Pack Size | Price |
| (S)-(?)-4-Hydroxy-2-pyrrolidinone 97% | 479179 | 5g | $221 |
| (S)-(?)-4-Hydroxy-2-pyrrolidinone 97% | 479179 | 1g | $52.5 |
| (S)-(-)-4-Hydroxy-2-pyrrolidone >98.0%(GC) | H1368 | 1g | $203 |
| (S)-(-)-4-Hydroxy-2-pyrrolidinone | H953075 | 10g | $1055 |
| (S)-4-HYDROXY-2-PYRROLIDINONE 95.00% | APN0001929 | 10G | $2148.3 |
| More product size | |||
| Melting point | 156-159 °C (lit.) |
|---|---|
| alpha | -41 º (c=% in ethanol) |
| Boiling point | 363.6±35.0 °C(Predicted) |
| Density | 1.292±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| Water Solubility | Slightly soluble in water |
| pka | 13.62±0.20(Predicted) |
| form | Solid |
| color | White to off-white |
| optical activity | [α]23/D 43°, c = 1 in ethanol |
| BRN | 1524192 |
| InChI | 1S/C4H7NO2/c6-3-1-4(7)5-2-3/h3,6H,1-2H2,(H,5,7)/t3-/m0/s1 |
| InChIKey | IOGISYQVOGVIEU-VKHMYHEASA-N |
| SMILES | O[C@@H]1CNC(=O)C1 |
| CAS DataBase Reference | 68108-18-9(CAS DataBase Reference) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H302-H318 | |||||||||
| Precautionary statements | P280i-P301+P312a-P305+P351+P338-P310a-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-41 | |||||||||
| Safety Statements | 22-24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 |
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| NFPA 704 |
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(S)-4-Hydroxy-2-pyrrolidinone price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 479179 | (S)-(?)-4-Hydroxy-2-pyrrolidinone 97% | 68108-18-9 | 5g | $221 | 2025-07-31 | Buy |
| Sigma-Aldrich | 479179 | (S)-(?)-4-Hydroxy-2-pyrrolidinone 97% | 68108-18-9 | 1g | $52.5 | 2023-06-20 | Buy |
| TCI Chemical | H1368 | (S)-(-)-4-Hydroxy-2-pyrrolidone >98.0%(GC) | 68108-18-9 | 1g | $203 | 2025-07-31 | Buy |
| TRC | H953075 | (S)-(-)-4-Hydroxy-2-pyrrolidinone | 68108-18-9 | 10g | $1055 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | APN0001929 | (S)-4-HYDROXY-2-PYRROLIDINONE 95.00% | 68108-18-9 | 10G | $2148.3 | 2021-12-16 | Buy |
(S)-4-Hydroxy-2-pyrrolidinone Chemical Properties,Uses,Production
Chemical Properties
White crystal
Uses
The (S)-enantiomer intermediate in the preparation of Oxiracetam
Uses
(S)-()-4-Hydroxy-2-pyrrolidinone can be used as a starting material in the preparation of:
- Biologically significant pyrrolo[1,2:1′,2′]azepino[5,6-b]indole derivatives.
- Substituted azepanes by reacting with various aldehydes via photochemical [5+2] cycloaddition.
General Description
4-Hydroxy-2-pyrrolidinone is an important building block found in many bioactive compounds like streptopyrrolidine. It can be used as an intermediate in the synthesis of various γ-amino acids (GABA) and substituted 2-pyrrolidinones like cynometrine and cynodine.
Synthesis
10.1 g (100 mmol) of 2-oxiranylacetamide, CuI 0.95 g (5 mmol), cesium carbonate 2 g (200 mmol) was added to 150 ml of ammonia in a saturated solution of methanol, 55 for stirring reaction for 8 h, the reaction solution was concentrated under reduced pressure, 100 ml of water was added, dichloromethane extraction three times, saturated saline washed three times, the phase of ethyl acetate was concentrated under reduced pressure, and petroleum ether recrystallization to obtain (S)-(-)-4-hydroxy-2-pyrrolidinone 8.71g, yield 86.3%, HPLC purity 99.42% (area normalization method), ee value 99.67%.
(S)-4-Hydroxy-2-pyrrolidinone Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 272)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21595 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Klong Industrial Co., Ltd | 0086-519-68231162 | info@klongchem.com | CHINA | 131 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from (S)-4-Hydroxy-2-pyrrolidinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-13 | (S)-4-Hydroxy-2-pyrrolidinone
68108-18-9
|
US $3.00-9.00 / KG | 0.1KG | 99% | g-kg-tons, free sample is available | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-04-04 | (S)-4-Hydroxy-2-pyrrolidinone
68108-18-9
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2024-05-08 | 4-Hydroxy-2-pyrrolidone
68108-18-9
|
US $2800.00 / Kg | 1Kg | 98 | 500 Kg | R&D Scientific Inc. |
-
- (S)-4-Hydroxy-2-pyrrolidinone
68108-18-9
- US $3.00-9.00 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- (S)-4-Hydroxy-2-pyrrolidinone
68108-18-9
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-Hydroxy-2-pyrrolidone
68108-18-9
- US $2800.00 / Kg
- 98
- R&D Scientific Inc.
68108-18-9((S)-4-Hydroxy-2-pyrrolidinone)Related Search:
4-hydroxypyrrolidin-2-one
OxiracetaM Related CoMpound 2
Oxiracetam Related Compound 7
Oxiracetam
2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)acetaMide
1of4
2-PYRROLIDINONE, 4-HYDROXY-, (S)
2-PYRROLIDINONE, 4-HYDROXY-, (4S)-
(4S)-4-HYDROXYPYRROLIDIN-2-ONE
4-HYDROXY-PYRROLIDIN-2-ONE
(s)-(-)-β-hydroxy-γ-butyrolactam
(s)-β-hydroxy-γ-butyrolactam
(S)-(-)-4-HYDROXY-2-PYRROLIDINONE
(S)-(+)-4-HYDROXY-2-PYRROLIDINONE
(S)-4-HYDROXY-2-PYRROLIDINONE
(S)-4-HYDROXY-2-PYRROLIDONE
(S)-4-HYDROXY-PYRROLIDINE-2-ONE
SHPD
(S)-BETA-HYDROXY-GAMMA-BUTYROLACTAM
(S)-(-)-4-Hydroxy-2-pyrrolinone
(4S)-4-hydroxy-2-pyrrolidone
(S)-4-Hydroxy-pyrrolidin-2-one
(4S)-(-)-4-Hydroxy-2-oxopyrrolidine, (4S)-(-)-beta-Hydroxy-gamma-butyrolactam
(4S)-4-Hydroxy-2-pyrrolidinone
OxiracetaM iMpurity A
Oxiracetam Impurity 9
(S)-4-Mercapto-2-pyrrolidone
Oxiracetam Impurity A ((S)-4-Hydroxy-2-pyrrolidinone)
(S)-(-)-4-Hydroxy-2-pyrrolidinone 97%
(S)-4-Hydroxy-2-pyrrolidone,99%e.e.
Oxiracetam impurity H
Oxiracetam Impurity N
(S)-(-)-4-Hydroxy-2-pyrrolidone>
Busulfan Impurity1706
Oxiracetam impurities1718
(S)-(-)-4-Hydroxy-2-pyrrolidinone (Oxiracetam Impurity)
(S)-(?)-4-Hydroxy-2-pyrrolidinone
(S)-4-hydroxypyrrolidin-2-one, 98%min
68108-18-9
C4H7NO2
Heterocyclic Building Blocks
Pyrrolidines
Chiral Building Blocks
Asymmetric Synthesis
Amines
Chiral Reagents
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals
Chiral
Pyrrolidinone derivatives
Drug Intermediates
