Benzo[a]phenazin-5-ol
- CAS No.
- 2089-82-9
- Chemical Name:
- Benzo[a]phenazin-5-ol
- Synonyms
- sAJM589,sAJM-589;sAJM589 >=98% (HPLC);Benzo[a]phenazin-5-ol
- CBNumber:
- CB14822973
- Molecular Formula:
- C16H10N2O
- Molecular Weight:
- 246.26
- MDL Number:
- MFCD00437759
- MOL File:
- 2089-82-9.mol
Benzo[a]phenazin-5-ol Chemical Properties,Uses,Production
Uses
sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC50 of 1.8 μM[1].
Biological Activity
sAJM589 is a Myc inhibitor th at disrupts the Myc-Max heterodimer with an IC50 value of 1.8 μM. sAJM589 was shown to suppress cellular proliferation in a variety of MYC-dependent cancer cell line including strong inhibition of Burkitt lymphoma Raji cell line growth. The mechanism of action of sAJM589 is thought to involve increased ubiquitination of Myc by inhibition of Max binding to Myc, leading to proteasome-mediated degradation.
References
[1] Choi SH, et al. Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule. ACS Chem Biol. 2017 Nov 17;12(11):2715-2719. DOI:10.1021/acschembio.7b00799
Benzo[a]phenazin-5-ol Preparation Products And Raw materials
Raw materials
Preparation Products
Benzo[a]phenazin-5-ol Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19961 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44814 | 58 |
cjbscvictory | 13348960310 | 3003867561@qq.com | China | 10505 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29770 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |