Autotaxin inhibitor compound 1 (Autotaxin-IN-1)
- CAS No.
- 1619971-30-0
- Chemical Name:
- Autotaxin inhibitor compound 1 (Autotaxin-IN-1)
- Synonyms
- Autotaxin-IN-1;AutotaxinIN1,Autotaxin IN 1;Autotaxin inhibitor compound 1;Autotaxin inhibitor compound 1 (Autotaxin-IN-1);Ethanone, 1-[2-[(2,3-dihydro-1H-inden-2-yl)amino]-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-[2-(1H-1,2,3-triazol-5-yl)ethoxy]-
- CBNumber:
- CB14844498
- Molecular Formula:
- C21H23N7O2
- Molecular Weight:
- 405.45
- MDL Number:
- MFCD32201059
- MOL File:
- 1619971-30-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Autotaxin inhibitor compound 1 (Autotaxin-IN-1) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | UPC97130 | Autotaxin-in-1 | 1619971-30-0 | 25mg | $1281 | 2026-06-05 | Buy |
| Biosynth | UPC97130 | Autotaxin-in-1 | 1619971-30-0 | 50mg | $1782.5 | 2026-06-05 | Buy |
| Biosynth | UPC97130 | Autotaxin-in-1 | 1619971-30-0 | 100mg | $2852 | 2026-06-05 | Buy |
| DC Chemicals | DC20701 | Autotaxin inhibitor compound 1 >98% | 1619971-30-0 | 100mg | $800 | 2026-05-24 | Buy |
| DC Chemicals | DC20701 | Autotaxin inhibitor compound 1 >98% | 1619971-30-0 | 250mg | $1600 | 2026-05-24 | Buy |
Autotaxin inhibitor compound 1 (Autotaxin-IN-1) Chemical Properties, Uses, Production
Description
Autotaxin-IN-1 is a potent inhibitor of autotaxin.
Uses
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain[1].
in vivo
Autotaxin-IN-1 (i.v.; 1.0mg/kg) has T1/2 of 1.14 hours[1].
Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM h[1].
| Animal Model: | Normal rat[1] |
| Dosage: | 1.0 mg/kg, 10 mg/kg (Pharmacokinetic Study) |
| Administration: | I.v. (1.0 mg/kg); p.o. (10 mg/kg) |
| Result: | Has T1/2 of 1.14 hours (i.v.; 1.0mg/kg). Has Cmax of 660 nM and AUC of 3440 nMh (p.o.; 10 mg/kg). |
IC 50
Autotaxin: 2 nM (IC50)
References
[1] Jones SB, et al. Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design. ACS Med Chem Lett. 2016 Aug 2;7(9):857-61. DOI:10.1021/acsmedchemlett.6b00207
Autotaxin inhibitor compound 1 (Autotaxin-IN-1) Preparation Products And Raw materials
Raw materials
Preparation Products
Autotaxin inhibitor compound 1 (Autotaxin-IN-1) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
View Latest Price from Autotaxin inhibitor compound 1 (Autotaxin-IN-1) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Autotaxin-IN-1
1619971-30-0
|
$1670.00-2800.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-08-22 | Autotaxin-IN-1
1619971-30-0
|
$1670.00-2800.00 | 10g | TargetMol Chemicals Inc. |
-
- Autotaxin-IN-1
1619971-30-0
- $1670.00-2800.00
- TargetMol Chemicals Inc.
-
- Autotaxin-IN-1
1619971-30-0
- $1670.00-2800.00
- TargetMol Chemicals Inc.
