Cilostamide
- CAS No.
- 68550-75-4
- Chemical Name:
- Cilostamide
- Synonyms
- OCP 3689;OPC 3689;ciloalaMide;Cilostamide;Cilostamide,OPC 3689;Cilostamide, 10 mM in DMSO;Cilostamide, PDE3 inhibitor;Cilostamide - CAS 68550-75-4 - Calbiochem;N-cyclohexyl-4-[(2-hydroxyquinolin-6-yl)oxy]-N-methylbutanamide;6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one
- CBNumber:
- CB1444199
- Molecular Formula:
- C20H26N2O3
- Molecular Weight:
- 342.43
- MDL Number:
- MFCD00673958
- MOL File:
- 68550-75-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 186~188℃ |
|---|---|
| Boiling point | 594.3±50.0 °C(Predicted) |
| Density | 1.18±0.1 g/cm3(Predicted) |
| storage temp. | 0-6°C |
| solubility | Soluble in DMSO (up to 30 mg/ml). |
| form | White solid |
| pka | 11.12±0.70(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Cosmetics Ingredients Functions | SKIN PROTECTING |
| InChI | 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23) |
| InChIKey | UIAYVIIHMORPSJ-UHFFFAOYSA-N |
| SMILES | [nH]1c2c(cc[c]1=O)cc(cc2)OCCCC(=O)N(C3CCCCC3)C |
| FDA UNII | 45S5605Q18 |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Storage Class | 11 - Combustible Solids |
Cilostamide price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C7971 | Cilostamide phosphodiesterase inhibitor | 68550-75-4 | 5mg | $535 | 2026-04-30 | Buy |
| Sigma-Aldrich | 231085 | Cilostamide | 68550-75-4 | 10mg | $366 | 2026-04-30 | Buy |
| Cayman Chemical | 14455 | Cilostamide ≥98% | 68550-75-4 | 5mg | $82 | 2026-04-30 | Buy |
| Cayman Chemical | 14455 | Cilostamide ≥98% | 68550-75-4 | 10mg | $154 | 2026-04-30 | Buy |
| Cayman Chemical | 14455 | Cilostamide ≥98% | 68550-75-4 | 25mg | $322 | 2026-04-30 | Buy |
Cilostamide Chemical Properties, Uses, Production
Description
Cilostamide (68550-75-4) is a selective inhibitor of phosphodiesterase-3 (PDE3). Displays limited selectivity for PDE3A versus PDE3B (IC50 = 27 and 50 nM).1,2 Blocks PKB/Akt signaling pathway downstream via inhibition of Akt-activated PDE3B.3 Cilostamide reverses the effect of leptin on food intake and body weight.4
Uses
Serotonin receptor ligand
Uses
Cilostamide (OPC 3689) is a specific phosphodiesterase 3 (PDE3) inhibitor.
Definition
ChEBI: N-cyclohexyl-N-methyl-4-[(2-oxo-1H-quinolin-6-yl)oxy]butanamide is a member of quinolines.
Biological Activity
Selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC 50 values are 0.027 and 0.050 μ M for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC 50 = 16.8 μ M); anti-thrombotic. Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .
Biochem/physiol Actions
Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.
storage
Store at RT
References
[1] H HIDAKA. Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation.[J]. Journal of Pharmacology and Experimental Therapeutics, 1979, 211 1: 26-30.
[2] S. CHRISTENSEN T T. Chapter 19. Isozyme-Selective Phosphodiesterase Inhibitors as Antiasthmatic Agents[J]. Annual Reports in Medicinal Chemistry, 1994, 29 1: 185-194. DOI:10.1016/s0065-7743(08)60732-0
[3] F AHMAD. Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells.[J]. Journal of immunology, 2000, 164 9: 4678-4688. DOI:10.4049/jimmunol.164.9.4678
[4] ALLAN Z. ZHAO. A phosphatidylinositol 3-kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding[J]. Nature neuroscience, 2002, 5 8: 727-728. DOI:10.1038/nn885
Cilostamide Preparation Products And Raw materials
Cilostamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3989 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | sales@changyanchem.cn | China | 4998 | 55 |
View Latest Price from Cilostamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | Cilostamide
68550-75-4
|
$56.00-183.00 | 98.87% | 10g | TargetMol Chemicals Inc. |
-
- Cilostamide
68550-75-4
- $56.00-183.00
- 98.87%
- TargetMol Chemicals Inc.
