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Bractoppin

Bractoppin Structure
Bractoppin structure
CAS No.
2290527-07-8
Chemical Name:
Bractoppin
Synonyms
Bractoppin;Bractoppin, 10 mM in DMSO;(4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone;Methanone, [4-[(2-fluorophenyl)methyl]-1-piperazinyl](2-phenyl-1H-benzimidazol-6-yl)-;DNA break,Bractoppin,phosphopeptide,inhibit,DNA/RNA Synthesis,DNA damage,RAD51,G2 arrest,Inhibitor,BRCA1 tBRCT
CBNumber:
CB14844584
Molecular Formula:
C25H23FN4O
Molecular Weight:
414.47
MDL Number:
MFCD33402156
MOL File:
2290527-07-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:37:08
Product description Number Pack Size Price
(4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone AA01KJYW 1mg $56
(4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone AA01KJYW 5mg $105
(4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone AA01KJYW 10mg $156
(4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone ≥98% AA01KJYW 25mg $286
(4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone ≥98% AA01KJYW 50mg $429
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Bractoppin Properties

Boiling point 625.7±65.0 °C(Predicted)
Density 1.299±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (603.18 mM; Need ultrasonic)
pka 10.70±0.10(Predicted)
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

Bractoppin price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA01KJYW (4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone 2290527-07-8 1mg $56 2026-05-30 Buy
aablocks AA01KJYW (4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone 2290527-07-8 5mg $105 2026-05-30 Buy
aablocks AA01KJYW (4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone 2290527-07-8 10mg $156 2026-05-30 Buy
aablocks AA01KJYW (4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone ≥98% 2290527-07-8 25mg $286 2026-05-30 Buy
aablocks AA01KJYW (4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone ≥98% 2290527-07-8 50mg $429 2026-05-30 Buy
Product number Packaging Price Buy
AA01KJYW 1mg $56 Buy
AA01KJYW 5mg $105 Buy
AA01KJYW 10mg $156 Buy
AA01KJYW 25mg $286 Buy
AA01KJYW 50mg $429 Buy

Bractoppin Chemical Properties,Uses,Production

Uses

Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response[1].

References

[1] Jayaprakash Periasamy, et al. Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling. Cell Chem Biol. 2018 Jun 21;25(6):677-690.e12. DOI:10.1016/j.chembiol.2018.02.012

Bractoppin Preparation Products And Raw materials

Raw materials

Preparation Products

Bractoppin Suppliers

Global( 34)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19853 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39039 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2624 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9804 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 89686 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9710 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
BOC Sciences 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55

View Lastest Price from Bractoppin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bractoppin pictures 2026-05-11 Bractoppin
2290527-07-8
 $106.00-343.00 99.65% 10g TargetMol Chemicals Inc.
  • Bractoppin pictures
  • Bractoppin
    2290527-07-8
  • $106.00-343.00
  • 99.65%
  • TargetMol Chemicals Inc.

Bractoppin Spectrum

Bractoppin(2290527-07-8)1HNMR
Bractoppin Methanone, [4-[(2-fluorophenyl)methyl]-1-piperazinyl](2-phenyl-1H-benzimidazol-6-yl)- DNA break,Bractoppin,phosphopeptide,inhibit,DNA/RNA Synthesis,DNA damage,RAD51,G2 arrest,Inhibitor,BRCA1 tBRCT (4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone Bractoppin, 10 mM in DMSO 2290527-07-8