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HL001 (HL 001)

HL001 (HL 001) structure

CAS No.: 1186371-31-2

Chemical Name:: HL001 (HL 001)

Synonyms: HL001;HL001 (HL 001);Benzamide, N-[(9H-fluoren-9-ylamino)carbonyl]-2,6-dihydroxy-

CBNumber:: CB14844867

Molecular Formula:: C21H16N2O4

Molecular Weight:: 360.36

MDL Number:

MOL File:: 1186371-31-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:50

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HL001 (HL 001) Properties

Melting point	225-227 °C
Density	1.48±0.1 g/cm3(Predicted)
pka	7.40±0.35(Predicted)

HL001 (HL 001) price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0084096	HL001 98.90%	1186371-31-2	5mg	$303	2026-06-04	Buy
ChemScene	CS-0084096	HL001 98.90%	1186371-31-2	10mg	$487	2026-06-04	Buy
ChemScene	CS-0084096	HL001 98.90%	1186371-31-2	25mg	$975	2026-06-04	Buy
ChemScene	CS-0084096	HL001 98.90%	1186371-31-2	50mg	$1571	2026-06-04	Buy
ChemScene	CS-0084096	HL001 98.90%	1186371-31-2	100mg	$2546	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0084096	5mg	$303	Buy
CS-0084096	10mg	$487	Buy
CS-0084096	25mg	$975	Buy
CS-0084096	50mg	$1571	Buy
CS-0084096	100mg	$2546	Buy

HL001 (HL 001) Chemical Properties, Uses, Production

Uses

HL001 is an orally active small molecule inhibitor of Cyclophilin A (CypA) and a receptor antagonist of Lysophosphatidic acid 1 (LPA1). HL001 induces cell cycle arrest and apoptosis of tumor cells by p53. HL001 stabilizes p53 by down-regulating G3BP1, inducing reactive oxygen species and DNA damage. HL001 disrupts the interaction between MDM2 and p53-72R in a CypA dependent manner. HL001 has antitumor activity. HL001 can also be used to study pulmonary fibrosis[1][2].

IC 50

Cyclophilin A; LPA1 Receptor

References

[1] Lu W, et al. Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA. Oncogene. 2017 Aug 17;36(33):4719-4731. DOI:10.1038/onc.2017.41
[2] Yuki Y, et al. Preclinical evaluation of HL001, a novel lysophosphatidic acid 1 (LPA1) receptor antagonist, for idiopathic pulmonary fibrosis utilizing physiologically relevant stem cell-derived lung organoids. European Respiratory Journal 2023 62(suppl 67): OA898.

HL001 (HL 001) Preparation Products And Raw materials

Raw materials

Preparation Products

HL001 (HL 001) Suppliers

Global Suppliers ( 3)

Supplier	Tel	Email	Country	ProdList	Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6288	58
Guangzhou Younan Technology Co., Ltd	020-82000279 18988941452	YN_research@163.com	China	2984	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	11975	58

Supplier	Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Guangzhou Younan Technology Co., Ltd	58
Nanjing Shizhou Biology Technology Co.,Ltd	58

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HL001 (HL 001) HL001 Benzamide, N-[(9H-fluoren-9-ylamino)carbonyl]-2,6-dihydroxy- 1186371-31-2