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Y-27632

Y-27632 Structure
Y-27632 structure
CAS No.
146986-50-7
Chemical Name:
Y-27632
Synonyms
Y-27632;ROCK INHIBITOR;Y-276322HCl;Rock inhibitor y-27632;(1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide;CS-20;Y-27632/Y27632;Y-27632 99.87%;Y-27632Y125330;Y-27632 (2HCl),98%
CBNumber:
CB0699488
Molecular Formula:
C14H21N3O
Molecular Weight:
247.34
MDL Number:
MFCD03490488
MOL File:
146986-50-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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Y-27632 Properties

Melting point >260°C (dec.)
Boiling point 462.6±15.0 °C(Predicted)
Density 1.136±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility H2O: 14 mg/mL
form solid
pka 13.53±0.40(Predicted)
color white
Stability Hygroscopic
InChI InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1
InChIKey IYOZTVGMEWJPKR-IJLUTSLNSA-N
SMILES [C@@H]1(C(NC2C=CN=CC=2)=O)CC[C@@H]([C@H](N)C)CC1
FDA UNII 0X370ROP6H
UNSPSC Code 12352207
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P280
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
WGK Germany  3
Storage Class 12 - Non Combustible Liquids

Y-27632 price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 688001 Y-27632 InSolution, ≥95%, reversible, inhibitor of Rho kinases 500μg $175 2026-04-30 Buy
Sigma-Aldrich 5.09228 InSolution Y-27632, Sterile-Filtered, Cell Culture-Tested - CAS 146986-50-7 - Calbiochem 146986-50-7 2mg $417 2026-04-30 Buy
Sigma-Aldrich 688000 Y-27632 - CAS 146986-50-7 - Calbiochem 146986-50-7 1MG $265 2025-07-31 Buy
Sigma-Aldrich 688000 Y-27632 - CAS 146986-50-7 - Calbiochem 146986-50-7 5MG $948 2025-07-31 Buy
Sigma-Aldrich 688000 Y-27632 - CAS 146986-50-7 - Calbiochem 146986-50-7 10MG $1270 2025-07-31 Buy
Product number Packaging Price Buy
688001 500μg $175 Buy
5.09228 2mg $417 Buy
688000 1MG $265 Buy
688000 5MG $948 Buy
688000 10MG $1270 Buy

Y-27632 Chemical Properties,Uses,Production

Uses

Y-27632 Dihydrochloride is a salt analog of Y-27632, which is Rho-kinase inhibitor.

Definition

ChEBI: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory acti ity against Rho-associated protein kinase (ROCK) enzyme.

Biological Activity

Selective inhibitor of the Rho-associated protein kinase p160ROCK. K i values are 0.14, 26, 25 and >250 μ M for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC 50 = 600nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation.

in vivo

Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group[3]. Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group)[4].

IC 50

ROCK-I: 220 nM (Ki); ROCK-II: 300 nM (Ki); PKN: 3.1 μM (Ki); Citron kinase: 5.3 μM (Ki); PKCα: 73 μM (Ki); PKA: 25 μM (Ki)

Background

Y-27632 is a potent and selective ATP-competitive inhibitor of Rho-associated kinases, with Ki values of 0.22 µM and 0.30 µM for ROCK1 and ROCK2, respectively. In vitro kinase assays demonstrate that Y-27632 exhibits a 20-fold greater preference for ROCK when compared to citron kinase and protein kinase N. Research studies show that Y-27632 treatment of cells leads to inhibition of ROCK phosphorylation of myosin phosphatase subunit 1 at both Thr853 and Thr696, with a much greater inhibition of Thr853 phosphorylation. Y-27632 selectively inhibits smooth-muscle contraction by inhibiting Ca2+ sensitization. Additional research indicates that Y-27632 inhibits dissociation-induced apoptosis of cultured human embryonic stem cells over numerous passages and increases cloning efficiency.

References

[1] ishizaki t1, uehata m, tamechika i, keel j, nonomura k, maekawa m, narumiya s. pharmacological properties of y-27632, a specific inhibitor of rho-associated kinases. mol pharmacol. 2000 may;57(5):976-83.

Y-27632 Preparation Products And Raw materials

Raw materials

Preparation Products

Y-27632 Suppliers

Global( 283)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou MgPlus Pharmtech Co., Ltd. 0512-66727658 18115508618 phoenix888.ok@163.com China 1186 58
Changsha Hanchen Biotechnology Co., LTD 18175992585 wanglin@hanchibio.cn China 194 58
Changzhou Yongfeng Biomedicine Co. Ltd. 15006117673 2973592490@qq.com China 268 58
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 13761310616 39324283@qq.com China 1360 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Ascent Scientific 4401179829988 customerservice@ascentscientific.co.uk United Kingdom 279 60
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Supplier Advantage
Suzhou MgPlus Pharmtech Co., Ltd. 58
Changsha Hanchen Biotechnology Co., LTD 58
Changzhou Yongfeng Biomedicine Co. Ltd. 58
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chembest Research Laboratories Limited 61
Ascent Scientific 60
VDM Biochemicals 64

View Lastest Price from Y-27632 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Y-27632 pictures 2026-07-15 Y-27632
146986-50-7
 $31.00-80.00 99.72% 10g TargetMol Chemicals Inc.
Y-27632 DIHYDROCHLORIDE pictures 2020-01-08 Y-27632 DIHYDROCHLORIDE
146986-50-7
 $2.00 1g 98%MIN Career Henan Chemical Co
  • Y-27632 pictures
  • Y-27632
    146986-50-7
  • $31.00-80.00
  • 99.72%
  • TargetMol Chemicals Inc.

Y-27632 Spectrum

Y-27632 DIHYDROCHLORIDE(146986-50-7)1HNMR

146986-50-7(Y-27632)Related Search:

Y-27632 dihydrochloride (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Y-27632 (2HCl), 5 mg Y6 N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE
Y320 (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide (R)-(+)-3-Butyn-2-ol (R)-(1-(4-nitrophenyl))ethanol Y-27632
1,4-Cyclohexanebis(methylamine)

1of3

ROCK INHIBITOR (R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL)-CYCLOHEXANECARBOXAMIDE 2HCL (R)-(+)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL)CYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE (+)-R-TRANS-4-(AMINOETHYL)-N-(4-PYRIDYL)-CYCLOHEXANECARBOXAMIDE 2HCL H2O Y-27632 TRANS-4-[(1R)-1-AMINOETHYL]-N-4-PYRIDINYLCYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE Y-276322HCl 4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide dihydrochloride (1R,4r)-4-((R)-1-aMinoethyl)-N-(pyridin-4-yl)cyclohexanecarboxaMide dihydrochloride CyclohexanecarboxaMide,4-[(1R)-1-aMinoethyl]-N-4-pyridinyl-, trans- Y-27632/Y27632 Y-27632, Free Base, >99% (+)-Trans-4-[1(r)-aminoethyl]-n-(4-pyridyl)cyclohexane-1-carboxamide Y-27632 (2HCl),98% 4-[(1R)-1-Aminoethyl]-N-(4-pyridinyl)cyclohexanecarboxamide (1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide Y-27632, free base 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide 4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide dihydrochloride CS-20 4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide (+)-(R)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4(1H)-ylidene)cyclohexanecarboxamide Y-27632 dihydrochlor Rock inhibitor y-27632 trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide , Y-27632 Y-27632, 10 mM in DMSO Y-27632 99.87% Y-27632Y125330 146986-50-7 BioChemical Cell Biology Cell Signaling and Neuroscience Kinase/Phosphatase Biology Rho Kinase (ROCK) Serine/Threonine Kinase Inhibitors Inhibitors Protein Kinase Signalling Inhibitor APIs SiChem