IT603)
- CAS No.
- 292168-90-2
- Chemical Name:
- IT603)
- Synonyms
- IT603);(E/Z)-IT-603;IT-603 (IT 603;c-Rel Inhibitor, IT-603;(E/Z)-IT-603, 10 mM in DMSO;5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one;4-Imidazolidinone, 5-[(5-bromo-2-hydroxy-3-methoxyphenyl)methylene]-2-thioxo-;GVHD,Inhibitor,Nuclear factor-kappaB,(E/Z)IT603,immunomodulatory,(E/Z) IT 603,disease,inhibit,Nuclear factor-κB,therapy,NF-κB
- CBNumber:
- CB14844913
- Molecular Formula:
- C11H9BrN2O3S
- Molecular Weight:
- 329.17
- MDL Number:
- MFCD02109025
- MOL File:
- 292168-90-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
IT603) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0082234 | (E/Z)-IT-603 98.08% | 292168-90-2 | 5mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-0082234 | (E/Z)-IT-603 98.08% | 292168-90-2 | 10mg | $480 | 2021-12-16 | Buy |
| ChemScene | CS-0082234 | (E/Z)-IT-603 98.08% | 292168-90-2 | 25mg | $950 | 2021-12-16 | Buy |
| ChemScene | CS-0082234 | (E/Z)-IT-603 98.08% | 292168-90-2 | 50mg | $1450 | 2021-12-16 | Buy |
| ChemScene | CS-0082234 | (E/Z)-IT-603 98.08% | 292168-90-2 | 100mg | $2250 | 2021-12-16 | Buy |
IT603) Chemical Properties,Uses,Production
Uses
(E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). (E/Z)-IT-603 is also an I?Bα/c-Rel inhibitor. IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases[1].
Biological Activity
Cell permeable: yes', 'Primary Target
c-Rel', 'Reversible: yes
References
[1] Yusuke Shono, et al. A small molecule c-Rel inhibitor reduces alloactivation of T-cells without compromising anti-tumor activity. Cancer Discov. 2014 May; 4(5): 578-591. DOI:10.1158/2159-8290.CD-13-0585
[2] Huang X, et al. ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway. Front Immunol. 2025 Jan 9;15:1529226. DOI:10.3389/fimmu.2024.1529226
IT603) Preparation Products And Raw materials
Raw materials
Preparation Products
IT603) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4611 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6439 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
View Lastest Price from IT603) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-07 | (E/Z)-IT-603
292168-90-2
|
US $54.00-213.00 / mg | 98.97% | 10g | TargetMol Chemicals Inc. |
-
- (E/Z)-IT-603
292168-90-2
- US $54.00-213.00 / mg
- 98.97%
- TargetMol Chemicals Inc.