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Peficitinib hydrobromide

Peficitinib hydrobromide Structure
Peficitinib hydrobromide structure
CAS No.
1353219-05-2
Chemical Name:
Peficitinib hydrobromide
Synonyms
RMA-849;Peficitinib Hydrobromid;Pemigatinib hydrobromide;Peficitinib hydrobromide;Peficitinib hydrobromide (JAN/USAN);anti-4-((5-Hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide;4-(5-Hydroxytricyclo3.3.1.13,7dec-2-yl)amino-1H-pyrrolo2,3-bpyridine-5-carboxamide hydrobromide (1:1) stereoisomer
CBNumber:
CB14848254
Molecular Formula:
C18H22N4O2.BrH
Molecular Weight:
407.31
MDL Number:
MFCD30747936
MOL File:
1353219-05-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Peficitinib hydrobromide Properties

InChI InChI=1S/C18H22N4O2.BrH/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10;/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22);1H
InChIKey ZUVPMAPXNYGJQC-UHFFFAOYSA-N
SMILES N(C1C(=CN=C2NC=CC=12)C(=O)N)C1C2CC3CC(O)(C2)CC1C3.Br
FDA UNII U55XHZ5X6P

Peficitinib hydrobromide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA020JEK Peficitinib hydrobromide 95% 1353219-05-2 100mg $810 2026-06-01 Buy
aablocks AA020JEK Peficitinib hydrobromide 95% 1353219-05-2 250mg $1575 2026-06-01 Buy
Product number Packaging Price Buy
AA020JEK 100mg $810 Buy
AA020JEK 250mg $1575 Buy

Peficitinib hydrobromide Chemical Properties, Uses, Production

Uses

Peficitinib (ASP015K) hydrobromide is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively[1].

Mechanism of action

Peficitinib hydrobromide potently inhibits the JAK-STAT pathway and blocks the signaling of pro-inflammatory cytokines such as IL-6 and IFN-γ. It has the strongest inhibitory activity against JAK3 (IC₅₀ = 0.7 nM), while also taking into account other subtypes (JAK1/2/Tyk2 IC₅₀ 3.9–5.0 nM).

Synthesis

Synthesis of Peficitinib hydrobromide    Peficitinib hydrobromide synthesis

in vivo

Peficitinib hydrobromide (1-30 mg/kg; p.o.; once daily for 24 days) shows dose-dependent efficacy both in prophylactic and therapeutic dosing regimens in an adjuvant-induced arthritis rat model[1].

Animal Model:Seven-weeks-old female Lewis rats, adjuvant-induced arthritis (AIA) model[1]
Dosage:1, 3, 10, and 30 mg/kg
Administration:Oral administration, once daily for 24 days
Result:Significantly inhibited the increase in paw volume at doses of 1 mg/kg or greater with an ED50 value of 2.7 mg/kg (95% confidence interval: 1.5–4.2 mg/kg). Significantly reduced the bone destruction score at 10 mg/kg or greater and almost fully ameliorated both paw swelling and bone destruction scores at 30 mg/kg.

IC 50

JAK3: 0.7 nM (IC50); JAK1: 3.9 nM (IC50); Tyk2: 4.8 nM (IC50); JAK2: 5 nM (IC50)

References

[1] Ito M, et al. A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model. J Pharmacol Sci. 2017 Jan;133(1):25-33. DOI:10.1016/j.jphs.2016.12.001

Peficitinib hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

Peficitinib hydrobromide Suppliers

Global Suppliers ( 46)
Supplier Tel Email Country ProdList Advantage
Shanghai Hope Chem Co., Ltd.， +21-18501659228 18501659228 info@hope-chem.com China 538 55
Cangzhou Enke Pharma-tech Co., Ltd. 0317-5296180 15533709196 enkepharma@126.com China 2495 55
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2969 58
Shenzhen Botel Biotechnology Co. Ltd. 13316949107 13316968096 1979313431@qq.com China 9619 58
Dideu Industries Group Limited +8617392712697 1022@dideu.com China 29089 58
Chengdu D-innovation Pharmaceutical Co.，LTD 028-85929779 18881048017 chenxuanruo@d-innovation.com China 208 58
Shanghai Yanze Chemical Co., Ltd. 15345144255 19901447308 260924549@qq.com China 9989 58
Anqing Benro pharmachem Technology Co.,Ltd. 05565209906 15391842992 794263564@qq.com China 125 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9867 58
Suzhou Lyco Pharmachem Co.,Ltd. 13771999217 13771999217 sales@lycopharmachem.com China 218 58
Supplier Advantage
Shanghai Hope Chem Co., Ltd.， 55
Cangzhou Enke Pharma-tech Co., Ltd. 55
Shanghai Rechem science Co., Ltd. 58
Shenzhen Botel Biotechnology Co. Ltd. 58
Dideu Industries Group Limited 58
Chengdu D-innovation Pharmaceutical Co.，LTD 58
Shanghai Yanze Chemical Co., Ltd. 58
Anqing Benro pharmachem Technology Co.,Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Suzhou Lyco Pharmachem Co.,Ltd. 58

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View Latest Price from Peficitinib hydrobromide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Peficitinib Hydrobromid pictures 2026-09-18 Peficitinib Hydrobromid
1353219-05-2
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Peficitinib Hydrobromid. pictures 2026-09-18 Peficitinib Hydrobromid.
1353219-05-2
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Peficitinib Hydrobromide pictures 2026-09-18 Peficitinib Hydrobromide
1353219-05-2
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

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1of2

Peficitinib hydrobromide (JAN/USAN) Peficitinib hydrobromide 4-(5-Hydroxytricyclo3.3.1.13,7dec-2-yl)amino-1H-pyrrolo2,3-bpyridine-5-carboxamide hydrobromide (1:1) stereoisomer Peficitinib Hydrobromid anti-4-((5-Hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide RMA-849 Pemigatinib hydrobromide 1353219-05-2 C18H22N4O2HBr