Peficitinib hydrobromide

1353219-05-2

CAS-Nr.: 1353219-05-2

Englisch Name:: Peficitinib hydrobromide

Synonyma:: Peficitinib Hydrobromid;Peficitinib hydrobromide;Peficitinib hydrobromide (JAN/USAN);anti-4-((5-Hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide;4-(5-Hydroxytricyclo3.3.1.13,7dec-2-yl)amino-1H-pyrrolo2,3-bpyridine-5-carboxamide hydrobromide (1:1) stereoisomer

CBNumber:: CB14848254

Summenformel:: C18H22N4O2. HBr

Molgewicht:: 407.31

MOL-Datei:: 1353219-05-2.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 37

Peficitinib hydrobromide Eigenschaften

InChI: InChI=1S/C18H22N4O2.BrH/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10;/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22);1H

InChIKey: ZUVPMAPXNYGJQC-UHFFFAOYSA-N

SMILES: N(C1C(=CN=C2NC=CC=12)C(=O)N)C1C2CC3CC(O)(C2)CC1C3.Br

Sicherheit

Peficitinib hydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden

Mechanism of action

Peficitinib hydrobromide potently inhibits the JAK-STAT pathway and blocks the signaling of pro-inflammatory cytokines such as IL-6 and IFN-γ. It has the strongest inhibitory activity against JAK3 (IC₅₀ = 0.7 nM), while also taking into account other subtypes (JAK1/2/Tyk2 IC₅₀ 3.9–5.0 nM).

Synthese

Synthesis of Peficitinib hydrobromide Peficitinib hydrobromide synthesis

Peficitinib hydrobromide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Peficitinib hydrobromide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 37)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368	sales@sjar-tech.com	China	504	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39031	58
Taizhou Creating Bio-pharm co., ltd.	0576-88827176; +8613586099526	post@creatingbiopharm.com	China	219	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	19961	58
Shaanxi Dideu New Materials Co. Ltd	+86-18192503167	1036@dideu.com	China	6761	58
Chongqing jooe co., ltd	+86-19923400328 +86-15223382610	info@jooe.com	China	5617	58
Shanghai Hope Chem Co., Ltd.，	+21-18501659228 18501659228	info@hope-chem.com	China	489	55
Nanjing Yikangda Pharmaceutical Technology Co.LTD	18118984557; 18118984557	753016615@qq.com	China	484	58
Tsingxin Biopharmaceutical Co., Ltd	18908011947	3903467217@qq.com	China	134	58
Jiangsu Vcare PharmaTech Co., Ltd.	025-58741518 13327700685	sales@vcarepharmatech.com	China	307	61

Peficitinib hydrobromide (JAN/USAN)
Peficitinib hydrobromide
4-(5-Hydroxytricyclo3.3.1.13,7dec-2-yl)amino-1H-pyrrolo2,3-bpyridine-5-carboxamide hydrobromide (1:1) stereoisomer
Peficitinib Hydrobromid
anti-4-((5-Hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide
1353219-05-2
C18H22N4O2HBr