Glycyrrhizic acid ammonium salt
- CAS No.
- 53956-04-0
- Chemical Name:
- Glycyrrhizic acid ammonium salt
- Synonyms
- MONOAMMONIUM GLYCYRRHIZINATE;Magnasweet;monoammoniumglycyrrhizate;glycyrrhizin monoammonium salt;Monoammonium Glycyrrhizinate S;GLYCYRRHIZINATE MONOAMMONIUM SALT;GLYCYRRHIZIC ACID MONOAMMONIUM SALT;GLYCAMIL;icorice);t from g
- CBNumber:
- CB1492372
- Molecular Formula:
- C42H65NO16
- Molecular Weight:
- 839.97
- MDL Number:
- MFCD00167400
- MOL File:
- 53956-04-0.mol
- MSDS File:
- SDS
| Melting point | >200°C (dec.) |
|---|---|
| Boiling point | 768.56°C (rough estimate) |
| Density | 1.1846 (rough estimate) |
| refractive index | 49 ° (C=1.5, EtOH) |
| FEMA | 2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.) |
| storage temp. | 2-8°C |
| solubility | Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides. |
| form | Powder or Crystals |
| color | Yellow to yellow-green |
| Odor | bland |
| optical activity | [α]20/D +48±4°, c = 1% in ethanol: water (1:1) |
| BRN | 3897076 |
| Stability | Hygroscopic |
| InChIKey | ILRKKHJEINIICQ-YDYGGSECSA-N |
| LogP | -0.9 |
| CAS DataBase Reference | 53956-04-0 |
| Substances Added to Food (formerly EAFUS) | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.) |
| SCOGS (Select Committee on GRAS Substances) | Ammoniated Glycyrrhizin |
| EWG's Food Scores | 4 |
| FDA UNII | 3VRD35U26C |
| EPA Substance Registry System | .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt (53956-04-0) |
| UNSPSC Code | 85151701 |
| NACRES | NA.76 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | LZ6500000 | |||||||||
| F | 3-10 | |||||||||
| HS Code | 29389090 | |||||||||
| NFPA 704 |
|
Glycyrrhizic acid ammonium salt price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000433 | Ammonium glycyrrhizate European Pharmacopoeia (EP) Reference Standard | 53956-04-0 | 70 mg | $225 | 2025-07-31 | Buy |
| Sigma-Aldrich | PHL82467 | Glycyrrhizin ammonium salt phyproof? Reference Substance | 53956-04-0 | 100MG | $268 | 2025-07-31 | Buy |
| Sigma-Aldrich | G0460000 | Glycyrrhizate monoammonium European Pharmacopoeia (EP) Reference Standard | 53956-04-0 | 300 mg | $164 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1029929 | Ammonium glycyrrhizate United States Pharmacopeia (USP) Reference Standard | 53956-04-0 | 100mg | $423 | 2025-07-31 | Buy |
| Sigma-Aldrich | 356780 | Glycyrrhizin, Ammonium Salt - CAS 53956-04-0 - Calbiochem | 53956-04-0 | 5G | $111 | 2022-05-15 | Buy |
Glycyrrhizic acid ammonium salt Chemical Properties,Uses,Production
Description
§ 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza. Licorice extract is that portion of the licorice root that is, after maceration, extracted by boiling water. The extract can be further purified by filtration and by treatment with acids and ethyl alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried powder. (2) Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation followed by neutralization with dilute ammonia. Monoammonium glycyrrhizinate (C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.
Chemical Properties
Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation, followed by neutral- ization with dilute ammonia Monoammonium glycyrrhizinate (C42H62O16NH45H2O) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.
Chemical Properties
white to slightly yellow powder
Uses
Ammonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-infl ammatory drugs with which Ammonium Glycyrrhizinate is associated.
Uses
anti-cancer agent
Uses
pharmaceutical excipient, GRAS, sweetener
Uses
Glycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings.
Definition
ChEBI: Monoammonium glycyrrhizinate is an organic molecular entity.
General Description
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
Biochem/physiol Actions
Biologically active constituent in the sweet root of Glycyrrhiza species (licorice). Antiviral.
Anticancer Research
Glycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide.
Safety Profile
Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NH3.
target
ROS
Purification Methods
Crystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.]
Glycyrrhizic acid ammonium salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-17392712697 | 1022@dideu.com | China | 3995 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12338 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5251 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 9028 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21622 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2988 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
View Lastest Price from Glycyrrhizic acid ammonium salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-17 | Glycyrrhizic acid ammonium salt
53956-04-0
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-09-17 | Glycyrrhizic acid ammonium salt
53956-04-0
|
US $0.00 / KG | 1KG | 98.0% | 1000kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-09-11 | Glycyrrhizic acid ammonium salt
53956-04-0
|
US $0.00 / KG | 1KG | ≥98% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. |
-
- Glycyrrhizic acid ammonium salt
53956-04-0
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Glycyrrhizic acid ammonium salt
53956-04-0
- US $0.00 / KG
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Glycyrrhizic acid ammonium salt
53956-04-0
- US $0.00 / KG
- ≥98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
