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1-(Cyclopropylmethyl)piperazine

1-(Cyclopropylmethyl)piperazine Structure
1-(Cyclopropylmethyl)piperazine structure
CAS No.
57184-25-5
Chemical Name:
1-(Cyclopropylmethyl)piperazine
Synonyms
Cyclopropylmethyl-piperazin-1-;N-(Cyclopropylmethyl)piperazine;1-(Cyclopropylmethyl)piperazine;Piperazine, 1-(cyclopropylmethyl)-;1-(CYCLOPROPYLMETHYL)PIPERAZINE 97;[(Piperazin-1-yl)methyl]cyclopropane;1-(Cyclopropylmethyl)piperazine - [C13216];1-(cyclopropylmethyl)piperazine(SALTDATA: FREE);1-(CYCLOPROPYLMETHYL)PIPERAZINE 97 ISO 9001：2015 REACH;1-(Cyclopropylmethyl)piperazine, 97% colorless to yellow liquid
CBNumber:
CB1500178
Molecular Formula:
C8H16N2
Molecular Weight:
140.23
MDL Number:
MFCD00872053
MOL File:
57184-25-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:49:17
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1-(Cyclopropylmethyl)piperazine Properties

Boiling point 68 °C/3.5 mmHg
Density 0.943 g/mL at 25 °C
refractive index n20/D 1.489
Flash point 171 °F
storage temp. 2-8°C
pka 9.25±0.10(Predicted)
form liquid
color Light brown
InChI InChI=1S/C8H16N2/c1-2-8(1)7-10-5-3-9-4-6-10/h8-9H,1-7H2
InChIKey IVLIBVDZIYFXBZ-UHFFFAOYSA-N
SMILES N1(CC2CC2)CCNCC1
CAS DataBase Reference 57184-25-5
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H227-H315-H335-H318
Precautionary statements  P280-P305+P351+P338-P210e-P261-P280a-P405-P501a
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  41
Safety Statements  26-36/39
RIDADR  UN 1993 / PGIII
WGK Germany  2
Hazard Note  Irritant
HS Code  2933599590
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Dam. 1

1-(Cyclopropylmethyl)piperazine price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 658839 1-(Cyclopropylmethyl)piperazine 97% 57184-25-5 1g $67.4 2023-06-20 Buy
TCI Chemical C3858 1-(Cyclopropylmethyl)piperazine min. 95.0 % 57184-25-5 1G $31 2026-04-30 Buy
TCI Chemical C3858 1-(Cyclopropylmethyl)piperazine min. 95.0 % 57184-25-5 5G $99 2026-04-30 Buy
Biosynth HCA18425 1-(Cyclopropylmethyl)piperazine 57184-25-5 10g $354 2026-06-04 Buy
Biosynth HCA18425 1-(Cyclopropylmethyl)piperazine 57184-25-5 100g $2360 2026-06-04 Buy
Product number Packaging Price Buy
658839 1g $67.4 Buy
C3858 1G $31 Buy
C3858 5G $99 Buy
HCA18425 10g $354 Buy
HCA18425 100g $2360 Buy

1-(Cyclopropylmethyl)piperazine Chemical Properties, Uses, Production

Uses

1-(Cyclopropylmethyl)piperazine is a compound involved in the preparation of N-substituted piperazinopyridylsteroid derivatives as abiraterone analogs that inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines.

Synthesis

N-Boc-4-(Cyclopropylmethyl)piperazine

373608-50-5

1-(CYCLOPROPYLMETHYL)PIPERAZINE

57184-25-5

S3: In a 10L four-necked flask equipped with a mechanical stirrer and a thermometer, N-Boc-4-(cyclopropylmethyl)piperazine (2.00 kg, 8.32 mol) and 5 kg of isopropanol were added and heated up to 40 °C. Concentrated hydrochloric acid (2.04 kg, 20.80 mol) was slowly added dropwise, and the reaction temperature was controlled between 40°C and 50°C. After the dropwise addition, the reaction was maintained at 40°C to 50°C with stirring for 4 hours. Upon completion of the reaction, the reaction solution was concentrated to remove most of the isopropanol and cooled to 0 °C. The pH of the residue was adjusted to 10-11 with 5 mol/L aqueous sodium hydroxide. extraction was carried out with dichloromethane (5L x 3), the organic phases were combined and washed once with 5 kg of saturated aqueous sodium chloride. The organic phase was diluted with dichloromethane to give 1.11 kg of a light yellow liquid 1-cyclopropylmethylpiperazine in 94% yield. The NMR spectrum of the product was consistent with the standard spectrum.

References

[1] Patent: CN108341792, 2018, A. Location in patent: Paragraph 0030; 0035
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 11, p. 2833 - 2838
[3] Patent: EP2481739, 2012, A1. Location in patent: Page/Page column 68
[4] Patent: WO2018/5860, 2018, A1. Location in patent: Page/Page column 172; 201; 203

1-(Cyclopropylmethyl)piperazine Preparation Products And Raw materials

Raw materials

N-Boc-4-(Cyclopropylmethyl)piperazine Hydrochloric acid Isopropyl alcohol

Preparation Products

N-((1r,4r)-4-(4-(cyclopropylMethyl)piperazin-1-yl)cyclohexyl)acetaMide

1-(Cyclopropylmethyl)piperazine Suppliers

Global Suppliers ( 148)
Supplier Tel Email Country ProdList Advantage
Chengdu Aofan Pharmtech Co.,Ltd 15281070185; 13038283958 2865097598@qq.com China 111 55
Nantong Xiaochang Pharmaceutical Trading Co., Ltd. 0513-82104991 18862997351 sales11@btcpharm.com China 859 58
Shanghai Biobond Pharmaceutical Co.,Ltd. 21-68719686 18917373795; sales@sh-biobond.cn China 94 58
Sichuan Fanzhijian Biomedical Technology Co., Ltd 15281070185 2865097598@qq.com China 60 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Supplier Advantage
Chengdu Aofan Pharmtech Co.,Ltd 55
Nantong Xiaochang Pharmaceutical Trading Co., Ltd. 58
Shanghai Biobond Pharmaceutical Co.,Ltd. 58
Sichuan Fanzhijian Biomedical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Energy Chemical 61
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Adamas Reagent, Ltd. 59
Accela ChemBio Co.,Ltd. 64

View Latest Price from 1-(Cyclopropylmethyl)piperazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(CYCLOPROPYLMETHYL)PIPERAZINE 97 pictures 2026-08-20 1-(CYCLOPROPYLMETHYL)PIPERAZINE 97
57184-25-5
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
1-(CYCLOPROPYLMETHYL)PIPERAZINE 97 pictures 2024-02-26 1-(CYCLOPROPYLMETHYL)PIPERAZINE 97
57184-25-5
 1kg 98% BTC Nantong Pharmaceuticals Technology Co.,Ltd
1-(CYCLOPROPYLMETHYL)PIPERAZINE 97 pictures 2019-07-06 1-(CYCLOPROPYLMETHYL)PIPERAZINE 97
57184-25-5
 $1.00 1KG 99% 20kg Career Henan Chemical Co

1-(Cyclopropylmethyl)piperazine Spectrum

1-(CYCLOPROPYLMETHYL)PIPERAZINE(57184-25-5)1HNMR

57184-25-5 (1-(Cyclopropylmethyl)piperazine) Related Search:

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4-(3-Chloro-5-(trifluoromethyl)(2-pyridyl))piperazinyl 2-phenylcyclopropyl ketone 2-((4-(5-(Trifluoromethyl)-2-pyridyl)piperazinyl)carbonyl)cyclopropanecarboxylic acid 2-((4-(3-Chloro-5-(trifluoromethyl)-2-pyridyl)piperazinyl)carbonyl)cyclopropanecarboxylic acid 7-Benzyl-1,3-dimethyl-8-[4-(cyclopropylcarbonyl)piperazin-1-yl]-3,7-dihydro-1H-purine-2,6-dione [4-(1,3-Benzothiazol-2-yl)piperazino](cyclopropyl)methanone
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1-(cyclopropylmethyl)piperazine(SALTDATA: FREE) 1-(CYCLOPROPYLMETHYL)PIPERAZINE 97 [(Piperazin-1-yl)methyl]cyclopropane N-(Cyclopropylmethyl)piperazine Cyclopropylmethyl-piperazin-1- 1-(Cyclopropylmethyl)piperazine, 97% colorless to yellow liquid Piperazine, 1-(cyclopropylmethyl)- 1-(CYCLOPROPYLMETHYL)PIPERAZINE 97 ISO 9001：2015 REACH 1-(Cyclopropylmethyl)piperazine - [C13216] 1-(Cyclopropylmethyl)piperazine 57184-25-5 API intermediates Cycloalkanes Building Blocks Heterocyclic Building Blocks Piperazines Building Blocks C4 to C8 Chemical Synthesis Amines and Anilines Heterocycles Heterocyclic Building Blocks