α-Pseudouridine
- CAS No.
- 10017-66-0
- Chemical Name:
- α-Pseudouridine
- Synonyms
- carbauridine;Pseudouridine B;α-Pseudouridine;α-Pseudouricdine;ALPHA-Pseudouridine;5-(β-D-Ribofuranosyl)uracil from wheat bran;5-α-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione;PSEUDOURIDINE NATURAL B ISOMER*FROM WHEAT BRAN;5-(α-D-Ribofuranosyl)-2,4(1H,3H)-pyrimidinedione
- CBNumber:
- CB1504121
- Molecular Formula:
- C9H12N2O6
- Molecular Weight:
- 244.2
- MDL Number:
- MFCD00038458
- MOL File:
- 10017-66-0.mol
- MSDS File:
- SDS
| Density | 1.642±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
|---|---|
| pka | 8.413±0.10(predicted) |
| InChI | InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7-/s3 |
| InChIKey | PTJWIQPHWPFNBW-DVJSAIJENA-N |
| SMILES | C1(=O)NC=C([C@@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C(=O)N1 |&1:5,6,8,10,r| |
α-Pseudouridine Chemical Properties,Uses,Production
Description
Alpha-pseudouridine is an unusual nucleoside with a "glycosidic" carbon-carbon bond.
Uses
Alpha-Pseudouridine is an isomer of Pseudouridine. It is a by-product of the chemical synthesis of beta-pseudouridine, is eliminated in EnginZyme’s enzymatic synthesis process. Pseudouridine is a fundamental component of RNA, found in all classes and species except the messenger (mRNA) variety. It most abundant RNA modification, found in all three phylogenic domains of life. When used in place of uridine in artificial mRNA, pseudouridine has proven to be critical to the success of mRNA vaccines (such as those for Covid-19) and future mRNA-based treatments.
References
[1] BARáT V, CHEN A, LIM Y H. An improved stereodivergent and practical synthesis of α- and β-pseudouridines[J]. Reaction Chemistry & Engineering, 2022, 4: 798-803. DOI:10.1039/D2RE00381C.
[2] HAIQI XU. Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome[J]. Nature Methods, 2024, 21 11: 2024-2033. DOI:10.1038/s41592-024-02439-8.
[3] MARTIN HENGESBACH. Formation of a stalled early intermediate of pseudouridine synthesis monitored by real-time FRET.[J]. RNA, 2010, 16 3: 610-620. DOI:10.1261/rna.1832510.
α-Pseudouridine Preparation Products And Raw materials
α-Pseudouridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| Zhengzhou convergence chemical co., LTD | 037155153829 18003835034 | 3897192574@qq.com | China | 9982 | 58 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80514535 19917294565 | et@chemextension.com | China | 5061 | 58 |
| Shaanxi Didu New Material Co., Ltd | 81124267 17392282731 | 1046@dideu.com | China | 10000 | 58 |
| Shanghai Yanchun Biopharmaceutical Technology Co., Ltd | 4001-009266 17349750668 | product@sci-e.com | China | 2808 | 58 |
| Hangzhou Huiyi Biotechnology Co., LTD | 0571-89918262 13357170655 | chenlingwei@hizyme.com | China | 105 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 38862 | 58 |
| Pushan Industry (Shaanxi) Co., Ltd | 029-81310890 18165209495 | 2929288192@qq.com | China | 9768 | 58 |
| Wuhan pushida biotechnology co., Ltd | 18163336578 | 2139086656@qq.com | China | 2240 | 58 |
| Shanghai meikai technology co., ltd | 021-68689288 15300790979 | info@mkbio.com.cn | China | 9988 | 58 |
