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Pseudouridine

Pseudouridine Structure
Pseudouridine structure
CAS No.
1445-07-4
Chemical Name:
Pseudouridine
Synonyms
PSEUDOURIDINE;Pseudo-UTP;β-Pseudouridine;5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;5-Ribosyluracil;y-Uridine;NSC 162405;Pseudoruidine;Pseudourindine;Pseudouricdine
CBNumber:
CB7125832
Molecular Formula:
C9H12N2O6
Molecular Weight:
244.2
MDL Number:
MFCD00038458
MOL File:
1445-07-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-25 20:17:46
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Pseudouridine Properties

Melting point 222 °C
Density 1.641±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility Methanol (Very Slightly, Heated), Water (Slightly, Sonicated, Heated)
pka 8.52±0.10(Predicted)
form Solid
color White to Off-White
PH ~9.0
biological source synthetic (chemical)
Water Solubility water: soluble
λmax 264nm(MeOH)(lit.)
InChI InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/s3
InChIKey PTJWIQPHWPFNBW-IZFRNLNUNA-N
SMILES O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O)O |&1:1,2,3,7,r|
FDA UNII 7R0R6H6KEG
UNSPSC Code 41106305
NACRES NA.79

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  WGK 3
HS Code  2934.99.9001
Storage Class 13 - Non Combustible Solids

Pseudouridine price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SMB00912 Pseudouridine ≥98% 1445-07-4 25mg $74.5 2026-04-30 Buy
Sigma-Aldrich SMB00912 Pseudouridine ≥98% 1445-07-4 100mg $250 2026-04-30 Buy
TCI Chemical P2939 Pseudouridine (Synthetic) 1445-07-4 100MG $154 2026-04-30 Buy
TCI Chemical P2396 Pseudouridine >98.0%(HPLC) 1445-07-4 50mg $393 2026-04-30 Buy
Cayman Chemical 23383 β-Pseudouridine ≥95% 1445-07-4 5mg $107 2026-04-30 Buy
Product number Packaging Price Buy
SMB00912 25mg $74.5 Buy
SMB00912 100mg $250 Buy
P2939 100MG $154 Buy
P2396 50mg $393 Buy
23383 5mg $107 Buy

Pseudouridine Chemical Properties,Uses,Production

Description

β-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine. It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. Pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes. In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner.

Uses

An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.

Definition

ChEBI: Pseudouridine is a C-glycosyl pyrimidine that consists of uracil having a beta-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine. It has a role as a fundamental metabolite.

Origin

Pseudouridine (Ψ) was the first modified ribonucleotide discovered 7 decades ago, and it has been found in tRNA, rRNA, snRNA, mRNA, and other types of RNA[2].

Biochem/physiol Actions

Pseudouridine is essential for rRNA folding and for regulating translational accuracy and it is required for stabilizing the tRNA structure. Pseudouridine in rRNA and tRNA has been shown to fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation. Pseudouridine in snRNA has been shown to enhance spliceosomal RNA-pre-mRNA interaction to facilitate splicing regulation[1].

target

Human Endogenous Metabolite

Structure and conformation

Pseudouridine, being one of them, is the C5-glycoside isomer of uridine that contains a C-C bond between C1 of the ribose sugar and C5 of uracil, rather than usual C1-N1 bond found in uridine. The C-C bond gives it more rotational freedom and conformational flexibility.In addition, pseudouridine has an extra hydrogen bond donor at the N1 position.

References

[1] Mingjia Chen, Claus-Peter Witte. “A Kinase and a Glycosylase Catabolize Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine Monophosphate Accumulation.” Plant Cell 32 3 (2020): 722–739.
[2] Pedro Morais,  Yi-Tao Yu,  Hironori Adachi. “The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines.” Frontiers in Cell and Developmental Biology (2021): 789427.

Pseudouridine synthesis

57100-18-2
1445-07-4
Synthesis of Pseudouridine from PSEUDOISOCYTIDINE

Pseudouridine Preparation Products And Raw materials

Raw materials

2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[(1,1-dimethylethyl)diphenylsilyl]-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]- D-Ribitol, 1,4-anhydro-1-C-(2,4-dimethoxy-5-pyrimidinyl)-, (1S)- α-Pseudouridine 2,4(1H,3H)-Pyrimidinedione, 5-[2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]- 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[(1,1-dimethylethyl)diphenylsilyl]-β-D-ribofuranosyl]-
5-O-(1-Methoxy-1-Methylethyl)-2,3-O-(1-Methylethylidene)-D-ribonic Acid γ-Lactone PSEUDOISOCYTIDINE D(+)-Ribonic acid gamma-lactone

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Preparation Products

Pseudouridine Suppliers

Global( 306)Suppliers
Supplier Tel Email Country ProdList Advantage
Zhejiang Huida Biotech Co., LTD 0571-89903022 18679456698 zilong@hizyme.com China 8001 58
Shanghai shuodian Biotechnology Co., Ltd 18221553137 ddwuyu@126.com China 1071 58
Wuxi Jingyao Bio-Technology Co., Ltd. 88770633 13961738808 jingyaobiotech@126.com China 389 55
Suzhou Biosynthetica Co., Ltd. 0512-89581819; 18915732708 657839514@qq.com China 22 58
microBioSyn Biotech Co,. Ltd. 15300487802 jlin@microbiosyn.com China 49 58
CHANGZHOU YUBO CHEMICAL CO.,LTD. 13961462977 15295086982 2360549695@qq.com China 225 58
Shanghai Peiling Biological Technology Co., Ltd 13127581762 13127581762 peilingchem@sina.com China 511 58
Zhejiang Huida Biotech Co., Ltd. 0571-89903022 18679456698 zilong@hizyme.com China 7853 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Hongene Biotech Corporation 021-64757213 info@hongene.com China 672 61
Supplier Advantage
Zhejiang Huida Biotech Co., LTD 58
Shanghai shuodian Biotechnology Co., Ltd 58
Wuxi Jingyao Bio-Technology Co., Ltd. 55
Suzhou Biosynthetica Co., Ltd. 58
microBioSyn Biotech Co,. Ltd. 58
CHANGZHOU YUBO CHEMICAL CO.,LTD. 58
Shanghai Peiling Biological Technology Co., Ltd 58
Zhejiang Huida Biotech Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Hongene Biotech Corporation 61

Related articles

View Lastest Price from Pseudouridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pseudouridine pictures 2026-09-11 Pseudouridine
1445-07-4
 $800.00-999.00 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Pseudouridine pictures 2026-09-11 Pseudouridine
1445-07-4
 1g 98%min 1000g WUHAN FORTUNA CHEMICAL CO., LTD
Pseudouridine pictures 2026-07-21 Pseudouridine
1445-07-4
 $30.00-93.00 99.69% 10g TargetMol Chemicals Inc.
  • Pseudouridine pictures
  • Pseudouridine
    1445-07-4
  • $800.00-999.00
  • 99%
  • HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
  • Pseudouridine pictures
  • Pseudouridine
    1445-07-4
  • $30.00-93.00
  • 99.69%
  • TargetMol Chemicals Inc.

Pseudouridine Spectrum

Pseudouridine(1445-07-4)1HNMR

1445-07-4(Pseudouridine)Related Search:

6-Hydroxypurine Urapidil Impurity 20 ZEBULARINE Uridine 5''-Monophosphate N,N-Dibutyl-1-butanamine URAPIDIL 5-METHYL-
6-[(3-chloropropyl)amino]-1,3-dimethyluracil 2-Demethoxy-4-methoxy urapidil 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 2,4(1H,3H)-Pyrimidinedione, 1-α-L-arabinofuranosyl- 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[(1,1-dimethylethyl)diphenylsilyl]-β-D-ribofuranosyl]-
2,4(1H,3H)-Pyrimidinedione, 1-β-L-arabinofuranosyl- Uracil Uridine 1,3-DIMETHYLPSEUDOURIDINE 1-methylpseudouridine
Pseudouridine PSEUDOURIDINE CEP PSEUDOURIDINE-5'-TRIPHOSPHATE LITHIUM SALT

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PSEUDOURIDINE 5-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione 5-β-D-ribofuranosyluracil BETA-PSEUDOURIDINE B-Pseudouridine 5-β-D-Ribofuranosyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 5-β-D-Ribofuranosylpyrimidine-2,4(1H,3H)-dione Pseudouridine C 5-Ribosyluracil NSC 162405 β-D-Pseudouridine 2,4(1H,3H)-PyriMidinedione, 5-b-D-ribofuranosyl- y-Uridine 2,4(1H,3H)-Pyrimidinedione, 5-β-D-ribofuranosyl- Uridine Impurity 20（β-Pseudouridine） Pseudourindine Pseudoruidine Pseudouridine, Beta-Pseudouridine, ψ Pseudouridine, natural antibiotics, RNA modified nucleosides Pseudouricdine Uridine Impurity 2 (Pseudouridine) Pseudouridine, 10 mM in DMSO BETA-PSEUDOURIDINE ，98%min β-Pseudouridine Pseudo-UTP 5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1445-07-4 445-07-4 Bases & Related Reagents Carbohydrates & Derivatives Heterocycles Nucleotides Pharmaceutical Nucleosides