Methyl alpha-bromoacrylate 95
- CAS No.
- 4519-46-4
- Chemical Name:
- Methyl alpha-bromoacrylate 95
- Synonyms
- Methyl α-bromoacrylate;methyl α-bromoacrylate;Methyl 2-bromoprop-2-enoate;Methyl alpha-bromoacrylate 95;Methyl alpha-bromoacrylate 95%;2-Bromopropenoic acid methyl ester;2-bromopropyl-2-eneacidmethyl ester;Methyl α-bromoacrylate, CAS 4519-46-4;2-Propenoic acid, 2-broMo-, Methyl ester
- CBNumber:
- CB1505148
- Molecular Formula:
- C4H5BrO2
- Molecular Weight:
- 164.99
- MDL Number:
- MFCD08276754
- MOL File:
- 4519-46-4.mol
- MSDS File:
- SDS
| Boiling point | 70-75 °C48 mm Hg(lit.) |
|---|---|
| Density | 1.556 g/mL at 25 °C(lit.) |
| Flash point | 134 °F |
| storage temp. | -20°C |
| Appearance | Colorless to light yellow Liquid |
| InChI | InChI=1S/C4H5BrO2/c1-3(5)4(6)7-2/h1H2,2H3 |
| InChIKey | HVJXPDPGPORYKY-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C(Br)=C |
| CAS DataBase Reference | 4519-46-4 |
| UNSPSC Code | 12162002 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H226-H315-H319-H335 |
| Precautionary statements | P210-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| HazardClass | 3 |
| PackingGroup | Ⅲ |
| HS Code | 2916199590 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
Methyl alpha-bromoacrylate 95 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 588466 | Methyl α-bromoacrylate 95% | 4519-46-4 | 1g | $506 | 2026-04-30 | Buy |
| Apolloscientific | OR941547 | Methyl 2-bromoacrylate 99% | 4519-46-4 | 1g | $22 | 2026-06-04 | Buy |
| Apolloscientific | OR941547 | Methyl 2-bromoacrylate 99% | 4519-46-4 | 5g | $100 | 2026-06-04 | Buy |
| Apolloscientific | OR941547 | Methyl 2-bromoacrylate 99% | 4519-46-4 | 25g | $476 | 2026-06-04 | Buy |
| Apolloscientific | OR941547 | Methyl 2-bromoacrylate 99% | 4519-46-4 | 100g | $1881 | 2026-06-04 | Buy |
Methyl alpha-bromoacrylate 95 Chemical Properties, Uses, Production
Uses
Methyl α-bromoacrylate can undergo radical copolymerization with vinyl triacetoxysilane (VTAS) in the presence of azobisisobutyronitrile as the initiator. Dibromocyclopropanation of methyl α-bromoacrylate can yield methyl 1,1,2-tribromocyclopropanecarboxylate. It may be reduced with zinc dust and deuterium oxide to synthesize. Methyl acrylate-α-d with a high isotopic purity. These may undergo conjugate addition with methoxide, thiolates, oxime anions, hydrazones and EtZnCl to afford ester enolates.
Synthesis
292638-85-8
4519-46-4
Example-1 Preparation of α-bromo methyl acrylate: methyl acrylate (100 g) was mixed with dichloromethane (300 mL) and cooled to 0-5°C. Bromine (60 mL) was slowly added dropwise at 0-5°C and the dropwise process lasted for 1 hour. After completion of the reaction, the reaction mixture was stirred at 25-30 °C for 4-5 hours. Subsequently, 10% NaHCO3 solution (100 mL) was added, stirred for 30 minutes and left to stratify. Sodium carbonate (250 g) and triethylamine (160 mL) were added to the dichloromethane layer and stirred at 25-30 °C for 1 hour. The mixture was kept at the same temperature for 2 hours and then filtered. To the filtrate, 20% HCl solution (100 mL) was added, stirred for 30 minutes and left to stratify. The organic layer was washed with 20% HCl solution (100 mL). Finally, the solvent was removed by distillation under reduced pressure at less than 30 °C to give α-bromoacrylic acid methyl ester. Yield: 140 g.
References
[1] Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8561 - 8563
[2] Patent: WO2012/25936, 2012, A2. Location in patent: Page/Page column 8-9
[3] Patent: US2013/184469, 2013, A1. Location in patent: Paragraph 0027
[4] Patent: US2016/287726, 2016, A1. Location in patent: Paragraph 0079; 0080
Methyl alpha-bromoacrylate 95 Preparation Products And Raw materials
Methyl alpha-bromoacrylate 95 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Brain Biotechnology Co., Ltd. | 13564638271 | shhjiang1977@163.com | China | 2985 | 55 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 1999 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Nanjing Abix Biochemical Technology Co., Ltd. | 025-87193546 18652950785; | chemweiao@163.com | China | 9009 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Latest Price from Methyl alpha-bromoacrylate 95 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Methyl 2-bromoacrylate
4519-46-4
|
$22.00-88.00 | 1kg | 99% | 20kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-08-07 | METHYL ALPHA-BROMOACRYLATE 95
4519-46-4
|
$11.00-25.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-10 | Methyl 2-bromoacrylate
4519-46-4
|
$1.00 | 1g | 95--99% | 1ton | Career Henan Chemical Co |
-
- Methyl 2-bromoacrylate
4519-46-4
- $22.00-88.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- METHYL ALPHA-BROMOACRYLATE 95
4519-46-4
- $11.00-25.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Methyl 2-bromoacrylate
4519-46-4
- $1.00
- 95--99%
- Career Henan Chemical Co
