PPTN (free base)
- CAS No.
- 1160271-30-6
- Chemical Name:
- PPTN (free base)
- Synonyms
- PPTN（99.63%）;PPTN (free base);2-Naphthalenecarboxylic acid, 4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-
- CBNumber:
- CB15419923
- Molecular Formula:
- C29H24F3NO2
- Molecular Weight:
- 475.5
- MDL Number:
- MFCD34469294
- MOL File:
- 1160271-30-6.mol
- MSDS File:
- SDS
| Boiling point | 598.8±50.0 °C(Predicted) |
|---|---|
| Density | 1.259±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 10mg/mL, clear |
| pka | 4.02±0.30(Predicted) |
| form | powder |
| color | white to beige |
| InChIKey | UAHMBIXBIRLMAG-UHFFFAOYSA-N |
| SMILES | OC(C1=CC2=CC(C3=CC=C(C(F)(F)F)C=C3)=CC=C2C(C4=CC=C(C5CCNCC5)C=C4)=C1)=O.FC(F)(C(O)=O)F |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
PPTN (free base) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1809 | PPTN trifluoroacetate salt ≥98% (HPLC) | 1160271-30-6 | 5 mg | $192 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1809 | PPTN trifluoroacetate salt ≥98% (HPLC) | 1160271-30-6 | 25 mg | $770 | 2026-04-30 | Buy |
| ChemScene | CS-0079526 | PPTN 99.63% | 1160271-30-6 | 5mg | $130 | 2026-06-04 | Buy |
| ChemScene | CS-0079526 | PPTN 99.63% | 1160271-30-6 | 10mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-0079526 | PPTN 99.63% | 1160271-30-6 | 25mg | $422 | 2026-06-04 | Buy |
PPTN (free base) Chemical Properties, Uses, Production
Uses
PPTN is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity[1].
Biological Activity
PPTN is a very potent (IC50 = 1 nM) P2Y14 receptor antagonist th at does not interact with any other P2Y receptor at concentrations up to 10 μM. PPTN blocks UDP-glucose inhibition of forskolin-induced cAMP accumulation, and neutrophil chemotaxis towards UDP-glucose gradients with nM potency.
References
[1] Barrett MO, et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84(1):41-9. DOI:10.1124/mol.113.085654
[2] Lin J, et al. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochem Int. 2019 Dec;131:104567. DOI:10.1016/j.neuint.2019.104567
PPTN (free base) Preparation Products And Raw materials
Raw materials
Preparation Products
PPTN (free base) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 9998 | 58 |
| Shanghai Shengkun Biomedical Co., Ltd. | 15065661979 15065661979 | stonebiopharm@163.com | China | 1524 | 58 |
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