PPTN (free base)
- CAS No.
- 1160271-30-6
- Chemical Name:
- PPTN (free base)
- Synonyms
- PPTN（99.63%）;PPTN (free base);2-Naphthalenecarboxylic acid, 4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-
- CBNumber:
- CB15419923
- Molecular Formula:
- C29H24F3NO2
- Molecular Weight:
- 475.5
- MDL Number:
- MFCD34469294
- MOL File:
- 1160271-30-6.mol
PPTN (free base) price
PPTN (free base) Chemical Properties,Uses,Production
Uses
PPTN is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity[1].
Biological Activity
PPTN is a very potent (IC50 = 1 nM) P2Y14 receptor antagonist th at does not interact with any other P2Y receptor at concentrations up to 10 μM. PPTN blocks UDP-glucose inhibition of forskolin-induced cAMP accumulation, and neutrophil chemotaxis towards UDP-glucose gradients with nM potency.
References
[1] Barrett MO, et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84(1):41-9. DOI:10.1124/mol.113.085654
[2] Lin J, et al. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochem Int. 2019 Dec;131:104567. DOI:10.1016/j.neuint.2019.104567
PPTN (free base) Preparation Products And Raw materials
Raw materials
Preparation Products
PPTN (free base) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 984 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3907 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29545 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
| Guangzhou Yingze Biotechnology Co., Ltd. | 18933933202 | CHINA | 147 | 58 |
