insulin glargine
- CAS No.
- 160337-95-1
- Chemical Name:
- insulin glargine
- Synonyms
- Lantus;Solostar;Insulin, glycyl(A21)-arginyl(B31,B32)-;Unii-2zm8cx04rz;insulin glargine;Insulin Glargine RS;Insulin glargine CRS;Insulin glargine/C1A;Insulin Glargine EP/USP;Insulin Glargine (>90%)
- CBNumber:
- CB1547528
- Molecular Formula:
- C267H404N72O78S6
- Molecular Weight:
- 6062.89026
- MDL Number:
- MFCD09260251
- MOL File:
- 160337-95-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | -20°C, Inert atmosphere |
|---|---|
| solubility | Aqueous Acid (Very Slightly) |
| form | Liquid |
| color | White to Off-White |
| Sequence | A-chain: Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Gly; B-chain: Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Thr-Arg-Arg (Disulfide bridge: CysA6-CysA11, CysA7-CysB7, CysA20-CysB19) |
| InChIKey | COCFEDIXXNGUNL-RFKWWTKHSA-N |
| CAS DataBase Reference | 160337-95-1 |
| NCI Dictionary of Cancer Terms | insulin glargine; insulin glargine recombinant; Lantus |
| FDA UNII | 2ZM8CX04RZ |
| ATC code | A10AE04 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373 |
| Precautionary statements | P260-P314-P501 |
| WGK Germany | nwg |
| HS Code | 2937120000 |
| Storage Class | 11 - Combustible Solids |
insulin glargine price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001544 | Insulin glargine for peak identification European Pharmacopoeia (EP) Reference Standard | 160337-95-1 | 3.2 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0001542 | Insulin glargine European Pharmacopoeia (EP) Reference Standard | 160337-95-1 | 15 mg | $241 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1342059 | Insulin glargine United States Pharmacopeia (USP) Reference Standard | 160337-95-1 | 15.27MG | $537 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0001544 | Insulin glargine European Pharmacopoeia (EP) Reference Standard | 160337-95-1 | y0001544 | $220 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1342059 | Insulin glargine United States Pharmacopeia (USP) Reference Standard | 160337-95-1 | 15.06mg | $454 | 2022-05-15 | Buy |
insulin glargine Chemical Properties,Uses,Production
Uses
long-acting basal insulin analogue, helping control the blood sugar level of those with type 1 and type 2 diabetes mellitus. It is an analogue of human insulin made by replacing the asparagine residue at position A21 of the A-chain with glycine and adding
Uses
Insulin Glargine (>90%) is an insulin analogue used in the treatment of adults with type 1 or type 2 diabetes.
brand name
Lantus (Hoechst Marion Roussel).
Biological Activity
Insulin glargine is an approved long-acting insulin analog used for management of Diabetes Type 1 and Type 2. Insulin glargine is a human insulin analog where A-chain asparagine 21 was replaced by glycine and B-chain carboxy terminal was extended by two arginine residues.
in vivo
Insulin glargine (2-12.5 IU/kg; subcutaneous injection; 3-12 months) does not present a carcinogenic risk in rodents[2].
Insulin glargine (450 mg/kg; subcutaneous injection; 6 months) has an improving effect in a mouse model of diabetes[3].
| Animal Model: | Seven-week-old male db/db mice[3] |
| Dosage: | 450 mg/kg |
| Administration: | Subcutaneous injection (s.c.); 6 months |
| Result: | Significantly improved glucose tolerance. Upregulated pancreatic β-cell functional genes, such as INS1, Pdx1, Pax4 and Pax6. |
insulin glargine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yingxin Laboratory Equipment Co., Ltd. | 021-59178156 17002132182 | 3146474380@qq.com | China | 9997 | 58 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| China Nobel Chem Co., Limited | +86(0)21 60484900 | China | 762 | 50 | |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 | synchempharma@aliyun.com | China | 4988 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shandong Ono Chemical Co., Ltd. | 0539-6362799 20） | China | 9998 | 58 | |
| Jiaxing Deyi Chemical Co., Ltd. | 86-0573-85866609 18367600069 | 945717149@qq.com | China | 9507 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
