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Protamine sulfate

Protamine sulfate Structure
Protamine sulfate structure
CAS No.
9009-65-8
Chemical Name:
Protamine sulfate
Synonyms
Protamin sulfate;SALMINE;ProtaMine sulfates;PROTAMINE SULFATE SALT;Protamine sulfate, Salmine sulfate from salmon sperm;fluxema;usafd-4;dilangio;vasorelax;Ccris 8521
CBNumber:
CB7727744
Molecular Formula:
H2O4S
Molecular Weight:
0
MDL Number:
MFCD00132091
MOL File:
Mol file
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:05
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Protamine sulfate Properties

storage temp. -20°C
solubility H2O: 10 mg/mL
form amorphous powder
color white
Water Solubility It is sparingly soluble in water.
Sensitive Hygroscopic
Cosmetics Ingredients Functions SKIN CONDITIONING
FDA UNII 0DE9724IHC
EPA Substance Registry System Protamines, sulfates (9009-65-8)
UNSPSC Code 41116107
NACRES NB.21

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3
RTECS  VO9470000
F  21-10
TSCA  TSCA listed
HS Code  35040090
Storage Class 11 - Combustible Solids

Protamine sulfate price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2610 Protamine sulfate certified reference material, pharmaceutical secondary standard 9009-65-8 25MG $282 2026-04-30 Buy
Biosynth FP30984 Protamine sulfate 9009-65-8 1g $268.78 2026-06-04 Buy
Biosynth FP30984 Protamine sulfate 9009-65-8 2g $398.18 2026-06-04 Buy
Biosynth FP30984 Protamine sulfate 9009-65-8 5g $737.4 2026-06-04 Buy
Biosynth FP30984 Protamine sulfate 9009-65-8 10g $1092.4 2026-06-04 Buy
Product number Packaging Price Buy
PHR2610 25MG $282 Buy
FP30984 1g $268.78 Buy
FP30984 2g $398.18 Buy
FP30984 5g $737.4 Buy
FP30984 10g $1092.4 Buy

Protamine sulfate Chemical Properties,Uses,Production

Chemical Properties

White or almost white, hygroscopic powder.

Uses

It is suitable for personal care, cosmetic and pharmaceutical applications. It is used widely to reverse the anticoagulant effects of heparin. It acts as a heparin antagonist. It is also a weak anticoagulant. It may be used for the removal of DNA from protein samples or the purification of DNA binding proteins. Protamine sulfate may also be used as an alternative to polybrene in retroviral mediated gene transfer. Protamine sulfate has antibacterial properties and inhibits pepsin activity. Protamine sulfate and other polycations have been shown to inhibit the classical pathway of complement. It neutralizes the anticoagulant activity of heparin, and inhibits turnover of lipoproteins by lipoprotein lipase. The aggregation of erythrocytes in the presence of protamine sulfate, for application to the prediction of MN phenotypes, has been investigated.

Uses

Antidote (to heparin).

in vivo

Protamine sulfate can be used in animal modeling to create cystitis models[5].

Induction of cystitis model[5]
Background
The presence and activity of protamine sulfate may trigger the activation and inflammatory response of the host immune system. These immune responses can lead to the infiltration of inflammatory cells and the production of inflammatory mediators, such as cytokines and interleukins, which can lead to cystitis.
Specific Modeling Methods
Rat: Sprague-Dawley female &bull
Administration: 10 mg/mL irrigation in the urinary bladder once
Note
(1) 10 mg/ml protamine sulfate was injected into the rat bladder, and 2 mg/ml LPS was injected 30 minutes later
(2) 5 days later, the experimental animals were put to death under anesthesia, and the bladder was removed for observation.
Modeling Indicators
Physiological indicators: The turbidity, urine volume and the number of red blood cells in the urine of rats were detected.
Molecular changes: The levels of biomarkers IL-6, TNF-α and NF-κB in bladder tissues were detected.
Histological analysis: Hematoxylin and eosin staining were used to detect the number of mast cells in the bladder of rats.
Correlated Product(s): LPS (HY-D1056)
Opposite Product(s): /

Protamine sulfate Preparation Products And Raw materials

Raw materials

ASPHALTUM Protamine sulfate salt Salmon Talc Diethyl ether Ethanol 95%

Preparation Products

Protamine sulfate Suppliers

Global( 121)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Yingxin Laboratory Equipment Co., Ltd. 021-59178156 17002132182 3146474380@qq.com China 9997 58
Hydebio Labs Co., Limited 15961755722 mrkt@hydebiolabs.com China 145 58
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Spectrum Chemical Manufacturing Corp. 021-021-021-67601398-809-809-809 15221380277 marketing_china@spectrumchemical.com China 9643 60
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Shanghai Ruji Biology Technology Co., Ltd. +86-21-65211385-8001 36031160 sales@shruji.com China 3223 55
Nanjing Dulai Biotechnology Co., Ltd. 025-84699383-8003;025-846993838003-8003 18013301590 njduly@126.com China 3293 55
Shanghai BeiZhuo Biotech Co., Ltd. 021-61119791,13386096464 bzswkf@foxmail.com China 3916 50
Chengdu HuaXia Chemical Reagent Co. Ltd 400-1166-196 13458535857 cdhxsj@163.com China 13323 58
Supplier Advantage
Shanghai Yingxin Laboratory Equipment Co., Ltd. 58
Hydebio Labs Co., Limited 58
Adamas Reagent, Ltd. 59
Spectrum Chemical Manufacturing Corp. 60
Beijing HuaMeiHuLiBiological Chemical 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai Ruji Biology Technology Co., Ltd. 55
Nanjing Dulai Biotechnology Co., Ltd. 55
Shanghai BeiZhuo Biotech Co., Ltd. 50
Chengdu HuaXia Chemical Reagent Co. Ltd 58

View Lastest Price from Protamine sulfate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PROTAMINE SULFATE pictures 2026-09-14 PROTAMINE SULFATE
9009-65-8
 0.99 RongNa Biotechnology Co.,Ltd
Protamine sulfate pictures 2026-07-06 Protamine sulfate
9009-65-8
 $30.00-39.00 99.81% 10g TargetMol Chemicals Inc.
Protamine Sulfate pictures 2021-11-15 Protamine Sulfate
9009-65-8
 $200.00 100KG 98% 50ton/Month Qiuxian Baitai New Material Co., LTD

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