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RA-9

RA-9 structure

CAS No.: 919091-63-7

Chemical Name:: RA-9

Synonyms: RA-9 UPS inhibitor;RA-9, 10 mM in DMSO;(3E,5E)-3,5-Bis[(4-nitrophenyl)methylene]-4-piperidinone;4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-, (3E,5E)-;Unfolded,RA-9,cancer,RA 9,DUBs,Inhibitor,Apoptosis,Response,Deubiquitinase,cells,inhibit,Protein,ovarian,RA9,survival

CBNumber:: CB16188329

Molecular Formula:: C19H15N3O5

Molecular Weight:: 365.34

MDL Number:: MFCD28400615

MOL File:: 919091-63-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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RA-9 Properties

Melting point	230-233 °C(Solv: ethyl ether (60-29-7); acetonitrile (75-05-8))
Boiling point	588.5±50.0 °C(Predicted)
Density	1.414±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 4.17 mg/mL (11.41 mM; ultrasonic and warming and heat to 80°C)
pka	5.13±0.20(Predicted)
form	Solid
color	Light yellow to yellow
InChI	1S/C19H15N3O5/c23-19-15(9-13-1-5-17(6-2-13)21(24)25)11-20-12-16(19)10-14-3-7-18(8-4-14)22(26)27/h1-10,20H,11-12H2/b15-9+,16-10+
InChIKey	YUYPWAMLWZVHAE-KAVGSWPWSA-N
SMILES	O=C(/C(CNC/1)=C/C2=CC=C([N+]([O-])=O)C=C2)C1=C\C3=CC=C([N+]([O-])=O)C=C3
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

RA-9 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1206	RA-9 ≥98% (HPLC)	919091-63-7	5 mg	$111	2026-04-30	Buy
Sigma-Aldrich	SML1206	RA-9 ≥98% (HPLC)	919091-63-7	25 mg	$433	2026-04-30	Buy
Cayman Chemical	40838	RA-9 ≥98%	919091-63-7	5mg	$50	2026-04-30	Buy
Cayman Chemical	40838	RA-9 ≥98%	919091-63-7	10mg	$80	2026-04-30	Buy
Cayman Chemical	40838	RA-9 ≥98%	919091-63-7	50mg	$198	2026-04-30	Buy

Product number	Packaging	Price	Buy
SML1206	5 mg	$111	Buy
SML1206	25 mg	$433	Buy
40838	5mg	$50	Buy
40838	10mg	$80	Buy
40838	50mg	$198	Buy

RA-9 Chemical Properties, Uses, Production

Uses

RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells[1].

Biological Activity

RA-9 is a potent and selective inhibitor of cell-permeable proteasome-associated deubiquitinating enzymes (DUBs) with favorable toxicity and anticancer activity. It selectively induces apoptosis in ovarian cancer cell lines.

in vivo

RA-9 (5 mg/kg; ip; one-day on, two-days off) inhibits human ovarian cancer cell growth in vivo and prolongs survival in a mouse model for ovarian cancer.

< td class="col1 fwb"> Animal Model:

Six-week-old female immunodeficient (NCr nu/nu) mice
Dosage:	5 mg/kg
Administration:	Ip; one-day on, two-days off
Result:	Significant reduction in tumor burden at day 12.

target

References

[1] Coughlin K, et al. Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses. Clin Cancer Res. 2014;20(12):3174-3186. DOI:10.1158/1078-0432.CCR-13-2658

RA-9 Preparation Products And Raw materials

Raw materials

Preparation Products

RA-9 Suppliers

Global Suppliers ( 37)

Target	Value
DUBs ()

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	9777	55
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9729	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774 400-920-5774	sales@glpbio.cn	China	6705	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6378	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11123	58
Shandong Jirun Biomedical Technology Co., Ltd.	0539-0539-8613587 17661611089	2639273505@qq.com	China	237	58
Jinan Jiuli Biotechnology Co. , Ltd.	15865264761	486064515@qq.com	China	5000	58

Supplier	Advantage
Shanghai YuanYe Biotechnology Co., Ltd.	60
Tianjin Kailiqi Biotechnology Co., Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58
Shanghai Hongye Biotechnology Co. Ltd	58
TargetMol Chemicals Inc.	58
InvivoChem	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Shandong Jirun Biomedical Technology Co., Ltd.	58
Jinan Jiuli Biotechnology Co. , Ltd.	58

View Latest Price from RA-9 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	RA-9 919091-63-7	$45.00-113.00		99.31%	10g	TargetMol Chemicals Inc.

RA-9
919091-63-7
$45.00-113.00
99.31%
TargetMol Chemicals Inc.

RA-9 Spectrum

RA-9(919091-63-7)¹HNMR

919091-63-7 (RA-9) Related Search:

RA375 PI-1840 9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(phenylmethoxy)imino]- [1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo- 1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-

Doxorubicin hydrochloride

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4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-, (3E,5E)- RA-9 UPS inhibitor Unfolded,RA-9,cancer,RA 9,DUBs,Inhibitor,Apoptosis,Response,Deubiquitinase,cells,inhibit,Protein,ovarian,RA9,survival RA-9, 10 mM in DMSO (3E,5E)-3,5-Bis[(4-nitrophenyl)methylene]-4-piperidinone 919091-63-7