RA375
- CAS No.
- 2649154-57-2
- Chemical Name:
- RA375
- Synonyms
- RA375;Acetamide, N-[(1S)-2-[(3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-4-oxo-1-piperidinyl]-2-oxo-1-(phenylmethyl)ethyl]-2-chloro-
- CBNumber:
- CB18175875
- Molecular Formula:
- C30H25ClN4O7
- Molecular Weight:
- 589
- MDL Number:
- MOL File:
- 2649154-57-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 857.537±65.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| Density | 1.428±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| solubility |
Acetonitrile: Slightly soluble: 0.1-1 mg/ml DMSO: Sparingly soluble: 1-10 mg/ml |
| pka | 12.718±0.46(predicted) |
| form | Solid |
| color | Light yellow to yellow |
RA375 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41541 | RA-375 ≥98% | 2649154-57-2 | 1mg | $83 | 2026-04-30 | Buy |
| Cayman Chemical | 41541 | RA-375 ≥98% | 2649154-57-2 | 5mg | $207 | 2026-04-30 | Buy |
| Cayman Chemical | 41541 | RA-375 ≥98% | 2649154-57-2 | 10mg | $330 | 2026-04-30 | Buy |
| ChemScene | CS-0131470 | RA375 99.87% | 2649154-57-2 | 1mg | $81 | 2026-06-04 | Buy |
| ChemScene | CS-0131470 | RA375 99.87% | 2649154-57-2 | 5mg | $200 | 2026-06-04 | Buy |
RA375 Chemical Properties, Uses, Production
Uses
RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead[1].
in vivo
RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1].
| Animal Model: | RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1]. |
| Dosage: | 10 mg/kg. |
| Administration: | IP for a 5 days on, 2 days off cycle for two weeks. |
| Result: | Reduced ovarian tumor burden in mice. |
| Animal Model: | Female Balb/c mice[1]. |
| Dosage: | 5, 10, 20, 40, 60, 100 mg/kg (Pharmacological Analysis). |
| Administration: | IP single dose. |
| Result: | The dose of 40 mg/kg on alternate days for two weeks produced no observable toxicities or weight loss. |
References
[1] Ravi K Anchoori, et al. Structure-function Analyses of Candidate Small Molecule RPN13 Inhibitors With Antitumor Properties. PLoS One. 2020 Jan 15;15(1):e0227727. DOI:10.1371/journal.pone.0227727
RA375 Preparation Products And Raw materials
Raw materials
Preparation Products
RA375 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 10000 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
