2-Chloro-6-fluorobenzoic acid
- CAS No.
- 434-75-3
- Chemical Name:
- 2-Chloro-6-fluorobenzoic acid
- Synonyms
- RARECHEM AL BO 0022;LABOTEST-BB LT00454355;2-Chloro-6-flurobenzoic acid;2-CHLORO-6-FLUOROBENZOIC ACID;2-Chloro-6-fluorobenzoicacid97%;Benzoic acid, 2-chloro-6-fluoro-;2-Chloro-6-fluorobenzoic Acid >2-CHLORO-6-FLUROBENZOIC ACID pure;2-Chloro-6-fluorobenzoic acid 97%;2-Chloro-6-fluorobenzoic acid, 98+%
- CBNumber:
- CB1688854
- Molecular Formula:
- C7H4ClFO2
- Molecular Weight:
- 174.56
- MDL Number:
- MFCD00002417
- MOL File:
- 434-75-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Chloro-6-fluorobenzoic acid for synthesis | 8.41200 | 25G | $233 |
| 2-Chloro-6-fluorobenzoic Acid >98.0%(T) | C0992 | 10g | $42 |
| 2-Chloro-6-fluorobenzoic acid 97% | PC1861 | 100g | $29 |
| 2-Chloro-6-fluorobenzoic acid 97% | PC1861 | 250g | $58 |
| 2-Chloro-6-fluorobenzoic acid 97% | PC1861 | 1kg | $175 |
| More product size | |||
| Melting point | 155-157 °C(lit.) |
|---|---|
| Boiling point | 263.7±20.0 °C(Predicted) |
| Density | 1.4016 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 2.04±0.10(Predicted) |
| form | powder to crystal |
| color | White to Gray to Brown |
| BRN | 973857 |
| InChI | InChI=1S/C7H4ClFO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,(H,10,11) |
| InChIKey | XNTIGDVFBDJLTQ-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=C(F)C=CC=C1Cl |
| CAS DataBase Reference | 434-75-3(CAS DataBase Reference) |
| FDA UNII | EUQ5BP41S0 |
| NIST Chemistry Reference | 2-Chloro-6-fluorobenzoic acid(434-75-3) |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-37/38-36-20/21/22 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Chloro-6-fluorobenzoic acid price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.41200 | 2-Chloro-6-fluorobenzoic acid for synthesis | 434-75-3 | 25G | $233 | 2026-04-30 | Buy |
| TCI Chemical | C0992 | 2-Chloro-6-fluorobenzoic Acid >98.0%(T) | 434-75-3 | 10g | $42 | 2026-04-30 | Buy |
| Apolloscientific | PC1861 | 2-Chloro-6-fluorobenzoic acid 97% | 434-75-3 | 100g | $29 | 2026-06-04 | Buy |
| Apolloscientific | PC1861 | 2-Chloro-6-fluorobenzoic acid 97% | 434-75-3 | 250g | $58 | 2026-06-04 | Buy |
| Apolloscientific | PC1861 | 2-Chloro-6-fluorobenzoic acid 97% | 434-75-3 | 1kg | $175 | 2026-06-04 | Buy |
2-Chloro-6-fluorobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
White to light yellow crystal powder
Uses
2-Chloro-6-fluorobenzoic Acid is a versatile reactant used in the synthesis of biaryls via decarboxylative Pd-catalyzed cross-coupling with aryl iodides. Also used in the preparation of fluorinated biaryls and heterobiaryls using copper catalyzed decarboxylative cross-coupling of aryl and heteroalyl iodides or bromides with potassium polyfluorobenzoates.
General Description
2-Chloro-6-fluorobenzoic acid is a two-fold halogenated derivative of benzoic acid.
Synthesis
387-45-1
434-75-3
General procedure for the synthesis of 2-chloro-6-fluorobenzoic acid from 2-chloro-6-fluorobenzaldehyde: H3PO4 (454 mg, 3.78 mmol) was added to a solution of 2-chloro-6-fluorobenzamide (1.0 g, 6.31 mmol) in 25 mL of THF and 10 mL of H2O. The reaction mixture was stirred at room temperature for 10 min, followed by the addition of NaClO (1.88 g, 20.81 mmol) and 1.4 mL H2O2 (30% w/w). The reaction was continued to be stirred for 3 h at room temperature. After completion of the reaction, the reaction mixture was extracted with EtOAc. The combined organic layers were washed with 1 M NaOH aqueous solution. The combined aqueous layer was acidified with 1 M HCl aqueous solution to pH ≈ 1 and extracted again with EtOAc. The combined organic layers were washed with brine and dried with anhydrous Na2SO4. After filtration, the solvent was removed in vacuum to afford 1.10 g (99% yield) of 2-chloro-6-fluorobenzoic acid as a colorless solid, which could be used without further purification.1H NMR (400 MHz, CDCl3) δ: 7.44-7.37 (m, 1H), 7.31-7.27 (m, 1H) , 7.10-7.07 (m, 1H).
References
[1] ChemMedChem, 2016, vol. 11, # 23, p. 2607 - 2620
[2] Patent: WO2018/52903, 2018, A1. Location in patent: Page/Page column 47-48
[3] Tetrahedron Letters, 1988, vol. 29, # 16, p. 1967 - 1970
[4] Chemische Berichte, 1936, vol. 69, p. 2253,2255
2-Chloro-6-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 923 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3970 | 58 |
View Lastest Price from 2-Chloro-6-fluorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-04 | 2-Chloro-6-fluorobenzoic acid
434-75-3
|
$60.00 | 1KG | 99% | 300MT/year | Speranza Chemical Co., Ltd. | |
 |
2025-04-04 | 2-Chloro-6-fluorobenzoic acid
434-75-3
|
25KG | 97% | 1tone | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2024-11-21 | 2-Chloro-6-Fluorobenzoic Acid
434-75-3
|
50kg | 98.5% | Hangzhou MolCore BioPharmatech Co.,Ltd. |
-
- 2-Chloro-6-fluorobenzoic acid
434-75-3
- $60.00
- 99%
- Speranza Chemical Co., Ltd.
-
- 2-Chloro-6-fluorobenzoic acid
434-75-3
- $0.00
- 97%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-Chloro-6-Fluorobenzoic Acid
434-75-3
- 98.5%
- Hangzhou MolCore BioPharmatech Co.,Ltd.
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