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4,4'-Oxydianiline

4,4'-Oxydianiline Structure
4,4'-Oxydianiline structure
CAS No.
101-80-4
Chemical Name:
4,4'-Oxydianiline
Synonyms
ODA;Oxydianiline;Diaminodiphenyl ether;4,4-DIAMINODIPHENYL ETHER;4,4'-Diaminodiphenyl ether;ODC;Dadpe;4,4'-ODA;4,4-OXYDIANILINE;4-AMINOPHENYL ETHER
CBNumber:
CB1689134
Molecular Formula:
C12H12N2O
Molecular Weight:
200.24
MDL Number:
MFCD00007863
MOL File:
101-80-4.mol
MSDS File:
SDS
Last updated:2026-08-25 20:17:46
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4,4'-Oxydianiline Properties

Melting point 188-192 °C(lit.)
Boiling point 190 °C (0.1 mmHg)
Density 1.1131 (rough estimate)
vapor pressure 10 mm Hg ( 240 °C)
refractive index 1.6660 (estimate)
Flash point 426 °F
storage temp. Store below +30°C.
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 5.49±0.10(Predicted)
color White
Water Solubility Insoluble. <0.01 g/100 mL at 15 ºC
BRN 475735
Henry's Law Constant 6.6×105 mol/(m3Pa) at 25℃, HSDB (2015)
Stability Stable. Combustible. Incompatible with strong oxidizing agents. Hygroscopic.
Major Application cleaning products
cosmetics
environmental
food and beverages
personal care
InChI 1S/C12H12N2O/c13-9-1-5-11(6-2-9)15-12-7-3-10(14)4-8-12/h1-8H,13-14H2
InChIKey HLBLWEWZXPIGSM-UHFFFAOYSA-N
SMILES Nc1ccc(Oc2ccc(N)cc2)cc1
LogP 0.72 at 20℃
Toxicology and Carcinogenesis Bioassay of 4,4'-Oxydianiline for Possible Carcinogenicity (CASRN 101-80-4)
Substances of Very High Concern (SVHC) Candidate List 4,4'-oxydianiline and its salts (101-80-4)
CAS DataBase Reference 101-80-4(CAS DataBase Reference)
FDA UNII 28DLB4Z70T
Proposition 65 List 4,4'-Diaminodiphenyl ether (4,4'-Oxydianiline)
NIST Chemistry Reference Benzenamine, 4,4'-oxybis-(101-80-4)
IARC 2B (Vol. 29, Sup 7) 1987
EPA Substance Registry System 4,4'-Diaminodiphenyl ether (101-80-4)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)Environment (GHS09)
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301+H311+H331-H317-H340-H350-H361f-H410
Precautionary statements  P202-P273-P280-P301+P310-P302+P352+P312-P304+P340+P311
target organs Thyroid
Hazard Codes  T,N
Risk Statements  45-46-23/24/25-51/53-62-36/37/38-22-50/53-43
Safety Statements  53-45-61-36/37-26-20-60
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS  BY7900000
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  III
HS Code  29222900
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Aquatic Chronic 1
Carc. 1B
Muta. 1B
Repr. 2
Skin Sens. 1
STOT RE 2 Oral
Hazardous Substances Data 101-80-4(Hazardous Substances Data)
Toxicity LD50 orl-rat: 725 mg/kg HYSAAV 33,137,68
REACH Registrations Active
NFPA 704
0
3 0

4,4'-Oxydianiline price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46117 4,4′-Oxydianiline analytical standard 101-80-4 250mg $53.6 2022-05-15 Buy
TCI Chemical O0088 4,4'-Diaminodiphenyl Ether >98.0%(GC)(T) 101-80-4 25g $26 2026-04-30 Buy
TCI Chemical O0088 4,4'-Diaminodiphenyl Ether >98.0%(GC)(T) 101-80-4 500g $140 2026-04-30 Buy
TRC TRC-B405510-50G Bis(p-aminophenyl) Ether 101-80-4 50g $237 2026-06-03 Buy
TRC TRC-B405510-10G Bis(p-aminophenyl) Ether 101-80-4 10g $176 2026-06-03 Buy
Product number Packaging Price Buy
46117 250mg $53.6 Buy
O0088 25g $26 Buy
O0088 500g $140 Buy
TRC-B405510-50G 50g $237 Buy
TRC-B405510-10G 10g $176 Buy

4,4'-Oxydianiline Chemical Properties,Uses,Production

Uses

Bis(p-aminophenyl) Ether is a reagent used in the preparation of polyimide-silica composite membranes for gas separation techniques. In addition, it is used in the synthesis of polymer films for electrolyte membranes. Dyes and metabolites, Environmental Testing

Description

4,40-Oxydianiline is a white crystalline solid,or a beige powder. Molecular weight =200.26; Boilingpoint ≥300℃ (sublimes); Freezing/Meltingpoint = 186-187℃; Flash point =219℃. Very slightlysoluble in water.

Chemical Properties

Colorless crystalline

Chemical Properties

4-Aminophenyl ether is a resin used in the manufacture of a variety of industrial products. For example as, insulating varnishes, flame-retardant fi bers, wire enamels, coatings, and fi lms. It is also used for the manufacture of other fi re-resistant products.

Chemical Properties

4,40′-Oxydianiline is a white crystalline solid, or a beige powder.

Uses

Bis(p-aminophenyl) Ether is a reagent used in the preparation of polyimide-silica composite membranes for gas separation techniques. In addition, it is used in the synthesis of polymer films for elect rolyte membranes.

Uses

4,4'-diaminodiphenylether be used for preparation polyimide and epoxy resin material.

Uses

4,4'-Oxydianiline has been used to produce polyimide resins.

Production Methods

4-Aminophenyl ether was produced in relatively large volume (on the order of 100,000–1,000,000 lb) in the 1970s but has since declined significantly. The compound is used primarily in the production of polyimide and polyesterimide resins. These resins are used in the manufacture of temperature- resistant products such as wire enamels, coatings, film, insulating varnishes, and flame-retardant fibers.

Definition

ChEBI: 4-Aminophenyl ether is an aromatic ether.

General Description

Odorless colorless crystals or an odorless fine, beige powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4,4'-Oxydianiline oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. A mixture of liquid air and diethyl ether exploded spontaneously [MCA Case History 616(1960)].

Health Hazard

4-Aminophenyl ether is highly toxic to animals. There is suffi cient evidence as a carcinogenicity and has caused adenomas and carcinomas in the thyroid and liver of experimental rats.

Fire Hazard

4,4'-Oxydianiline is combustible.

Flammability and Explosibility

Not classified

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx

Potential Exposure

Intermediate in the manufacture of high-temperature-resistant, straight polyimide and poly (esterimide) resins capable of withstanding temperatures of Up to 480°C for short periods or 260°C for prolonged periods of time. Some p-phenylenediamine compounds have been used as rubber components, and DFG warns of danger of skin sensitization.

First aid

Skin Contact: Flood all areas of body that havecontacted the substance with water. Do not wait to removecontaminated clothing; do it under the water stream. Usesoap to help assure removal. Isolate contaminated clothingwhen removed to prevent contact by others. EyeContact: Remove any contact lenses at once. Immediatelyflush eyes well with copious quantities of water or normalsaline for at least 20-30 min. Seek medical attention.Inhalation: Leave contaminated area immediately; breathefresh air. Proper respiratory protection must be supplied toany rescuers. If coughing, difficult breathing, or any othersymptoms develop, seek medical attention at once, even ifsymptoms develop many hours after exposure. Ingestion:Contact a physician, hospital, or poison center at once. Ifthe victim is unconscious or convulsing, do not inducevomiting or give anything by mouth. Assure that thepatient’s airway is open and lay him on his side with hishead lower than his body and transport immediately to amedical facility. If conscious and not convulsing, give aglass of water to dilute the substance. Vomiting should notbe induced without a physician’s advice.

Carcinogenicity

4,4′-Oxydianiline is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in a refrigerator under an inert atmosphere.Protect from exposure to light and oxidizing agents. A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHAStandard 1910.1045.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides. Slowly hydrolyzes in water, releasing ammonia, and forming acetate salts. Decomposes at 265C releasing toxic oxides of nitrogen, sulfur, and carbon. Decomposed by strong ultraviolet light.

Waste Disposal

Incineration with provision for nitrogen oxides removal from flue gases.

4,4'-Oxydianiline synthesis

101-63-3
101-80-4
Synthesis of 4,4'-Oxydianiline from 4,4'-Dinitrodiphenyl ether

4,4'-Oxydianiline Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Sodium nitrite Ammonium chloride Sodium formate Hydrochloric acid
4-Nitrophenol Nitrobenzene EMULSIFIER Iron Potassium chloride
Activated carbon Sodium carbonate Citric acid

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Preparation Products

Polyimide film N,N'-(OXYDI-4,1-PHENYLENE)BISACETAMIDE 4,4'-Dinitrodiphenyl ether 4,4'-Oxydiphenol Acid Green 54

4,4'-Oxydianiline Suppliers

Global( 635)Suppliers
Supplier Tel Email Country ProdList Advantage
LinkChem Technology Co., Ltd. 58950110 13124863828 sales@linkchem.cn China 2993 58
Beijing Holiyang Chemical Co. Ltd. 13718199399 holiyangchem@163.com China 3271 56
Wuhan Qiaofeng Chemical Technology Co., Ltd. 18271818137 2814999308@qq.com China 299 58
Liling Chuangli Technology Co. LTD 0534-8101711 13606437406 sales@chuanglichem.com China 49 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd. 0519-85195575 15861192208;15861192208;13685253038 850305@sunkechem.com China 72 69
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
Supplier Advantage
LinkChem Technology Co., Ltd. 58
Beijing Holiyang Chemical Co. Ltd. 56
Wuhan Qiaofeng Chemical Technology Co., Ltd. 58
Liling Chuangli Technology Co. LTD 58
J & K SCIENTIFIC LTD. 76
Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd. 69
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56

Related articles

View Lastest Price from 4,4'-Oxydianiline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,4'-Oxydianiline pictures 2026-09-12 4,4'-Oxydianiline
101-80-4
 0.99 RongNa Biotechnology Co.,Ltd
4,4'-Oxydianiline pictures 2026-09-11 4,4'-Oxydianiline
101-80-4
 $2.00 1KG 99.5% 500mt/year Jinan Finer Chemical Co., Ltd
4,4'-Oxydianiline pictures 2026-09-11 4,4'-Oxydianiline
101-80-4
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD

4,4'-Oxydianiline Spectrum

4,4'-Oxydianiline(101-80-4)MS4,4'-Oxydianiline(101-80-4)1HNMR4,4'-Oxydianiline(101-80-4)IR14,4'-Oxydianiline(101-80-4)IR24,4'-Oxydianiline(101-80-4)Raman

101-80-4(4,4'-Oxydianiline)Related Search:

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Diethyl ether 2,2'-Oxydianiline 4,4'-DINITRODIPHENYL ETHER

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4,4'-Oxydianiline purified by sublimation, 99% 4,4'-Diaminodiphenyl ether for synthesis BIO-FARMA BF003088 BIS(4-AMINOPHENYL) ETHER BIS(P-AMINOPHENYL)ETHER 4,4'-DIAMINODIPHENYL OXIDE 4,4'-DIAMINOPHENYL ETHER 4,4'-DADPE 4,4'-DPE 4,4'-Diaminobiphenyl oxide 4,4'-Diaminophenyl oxide 4,4'-Oxybis[aniline] 4,4'-Oxydiphenylamine Aniline, 4,4'-oxydi- di(4-Aminophenyl) ether di-(4-aminophenyl)ether Ether, 4,4'-diaminodiphenyl- ether,4,4’-diaminodiphenyl NCI-C50146 oxybis(4-aminobenzene) Oxybis[4-aminobenzene] Oxydi-p-phenylenediamine p,p’-diaminodiphenylether p,p’-oxybis(aniline) p,p’-oxydianiline p,p'-Diaminodiphenyl ether p,p'-Oxybis(aniline) p,p'-Oxydianiline p-Aminophenyl ether p-aminophenylether 4-(4-Aminophenoxy)phenylamine 4,4’-biaminodiphenylether 4,4’-diaminobiphenyloxide 4,4’-diaminophenyloxide 4,4’-oxybisaniline 4,4’-oxybis-benzenamin 4,4’-oxybis-Benzeneamine 4,4’-oxydi-anilin 4,4’-oxydiphenylamine 4,4’-Bis(aminophenyl)ether 4,4'-diaminadiphenyl ether 4,4'-OXYDIANILINE, SUBLIMED, 99% 4,4'-OXYDIANILINE, SUBLIMED, ZONE-REFINE D, 99+% 4,4-OXYDIANILINE OEKANAL, 250 MG 4,4'-DIAMINODIPHENYL ETHER, ZONE REFINED 4 4'-OXYDIANILINE 98+% 4 4'-OXYDIANILINE 99.5% TIMTEC-BB SBB003546 ZERENEX ZX004984 4,4'-Diaminodiphenyl Oxide 4,4'-Oxydianiline ODA)4,4′-DiaMinodiphe 4,4′-Oxydianiline Solution, 100ppm 4,4'-DiaiMinodiphenyl ether 4,4- twoaMino twophenyl ether 4,4-Oxydianiline (ODA) 4-AMinophenyle 4,4'-OXYDIAMILINE(ODA) 4,4-DiaminodiphenylEther98%