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Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Structure
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate structure
CAS No.
2199-51-1
Chemical Name:
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
Synonyms
2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID ETHYL ESTER;Sunitinib Impurity 28;Sunitinib Impurity 41;Sunitinib malate INT III;Ethyl 2,4-diMethyl-1H-pyr...;2,4-Dimethyl-3-carbethoxypyrrole;4-dimethyl-1H-pyrrole-3-carboxylate;ETHYL 2,4-DIMETHYL-PYRROLE-3-CARBOXYLATE;Ethyl2,4-Dimethylpyrrole-3-carboxylate>2,4-Dimethyl-3-(ethoxycarbonyl)-1H-pyrrole
CBNumber:
CB1696136
Molecular Formula:
C9H13NO2
Molecular Weight:
167.21
MDL Number:
MFCD01365811
MOL File:
2199-51-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:44:06
Request For Quotation

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Properties

Melting point 122-123°C
Boiling point 162°C/11mmHg(lit.)
Density 1.1222 (rough estimate)
refractive index 1.4680 (estimate)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Soluble), Chloroform (Slightly), Methanol (Slightly)
pka 16.44±0.50(Predicted)
form Solid
color Red to Very Dark Red
λmax 258nm(EtOH)(lit.)
InChI InChI=1S/C9H13NO2/c1-4-12-9(11)8-6(2)5-10-7(8)3/h5,10H,4H2,1-3H3
InChIKey QWSFDUPEOPMXCV-UHFFFAOYSA-N
SMILES N1C=C(C)C(C(OCC)=O)=C1C
CAS DataBase Reference 2199-51-1(CAS DataBase Reference)
NIST Chemistry Reference 2,4-Dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester(2199-51-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)Environment (GHS09)
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301+H331-H315-H319-H360-H371-H373-H317-H334-H341-H350-H410
Precautionary statements  P501-P273-P272-P260-P270-P202-P201-P271-P264-P280-P284-P302+P352-P391-P337+P313-P305+P351+P338-P308+P311-P362+P364-P333+P313-P301+P310+P330-P304+P340+P311-P403+P233-P405
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39-45-22
Hazard Note  Irritant
HS Code  29337900

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical E1075 Ethyl 2,4-Dimethylpyrrole-3-carboxylate >98.0%(GC) 2199-51-1 1g $38 2026-04-30 Buy
TCI Chemical E1075 Ethyl 2,4-Dimethylpyrrole-3-carboxylate >98.0%(GC) 2199-51-1 5g $152 2026-04-30 Buy
Usbiological 270842 2,4-Dimethylpyrrole-3-carboxylic acid ethyl ester Asreported 2199-51-1 250mg $333 2026-06-03 Buy
Usbiological 270842 2,4-Dimethylpyrrole-3-carboxylic acid ethyl ester Asreported 2199-51-1 500mg $468 2026-06-03 Buy
Usbiological 270842 2,4-Dimethylpyrrole-3-carboxylic acid ethyl ester Asreported 2199-51-1 1g $612 2026-06-03 Buy
Product number Packaging Price Buy
E1075 1g $38 Buy
E1075 5g $152 Buy
270842 250mg $333 Buy
270842 500mg $468 Buy
270842 1g $612 Buy

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Chemical Properties,Uses,Production

Chemical Properties

White to light brown crystalline

Uses

2,4-Dimethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is used in the preparation of blue pyrrole dyes. 2,4-Dimethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is also used as an intermediate in the synthesis of receptor tyrosine kinase (RTK) inhibitors and their metabolites.

Uses

ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate is used in the preparation of blue pyrrole dyes. It is also used as an intermediate in the synt hesis of receptor tyrosine kinase (RTK) inhibitors and their metabolites.

Synthesis

3,5-Dimethylpyrrole-2,4-dicarboxylic acid 2-t-butyl ester-4-ethyl ester

86770-31-2

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

2199-51-1

Step (ii): Preparation of 2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester In a 10-liter four-necked round-bottomed flask equipped with a mechanical stirrer, thermometer casing, gas introduction tube, and air condenser, 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester (II) (1.5 kg, 5.6 mol) and isopropanol (4.5 L) were added and stirred at 25-30 °C. Concentrated hydrochloric acid (2.2 L) was added slowly through the addition funnel. After addition, the reaction mixture was warmed up to 45-50 °C and maintained at this temperature until complete cessation of gas release. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the solution was cooled to 25-30 °C and quenched in an ice-water bath. The product was separated by filtration and dried at 50 °C. A dried product of 721.3 g was obtained with 77.3% yield and >96% HPLC purity.

References

[1] Synlett, 2010, # 17, p. 2561 - 2564
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3062 - 3065
[3] Journal of the American Chemical Society,
[4] Journal of the American Chemical Society, 2009, vol. 131, p. 8578 - 8586
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 1, p. 139 - 146

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate synthesis

5442-91-1
2199-51-1
Synthesis of Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate from 4-(Ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Preparation Products And Raw materials

Raw materials

1H-Pyrrole-1,3-dicarboxylic acid, 2,4-dimethyl-, 1-(1,1-dimethylethyl) 3-ethyl ester 2-Benzyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate Ethyl 3-methyl-4-oxocrotonate 4-(Ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid 3,5-Dimethylpyrrole-2,4-dicarboxylic acid 2-t-butyl ester-4-ethyl ester
Diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate Methyllithium Ethyl acetoacetate Acetonitrile Hydrochloric acid

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Preparation Products

(Z)-ethyl 5-((5-fluoro-2-oxoindolin-3-ylidene)Methyl)-2,4-diMethyl-1H-pyrrole-3-carboxylate Ethyl 2,4-dimethyl-5-nitro-1H-pyrrole-3-carboxylate 1H-Pyrrole-3-carboxylicacid,2,4-dimethyl-5-(1-oxopropyl)-,ethylester(9CI) Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Suppliers

Global( 261)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Guangchen Pharmaceutical Technology Co., Ltd 18563726319 2845578351@qq.com China 7026 58
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD 0838-2809458 13350585791 pharm@biots.cn China 747 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Sichuan Tongsheng Amino acids Co.,Ltd. 0838-2274206 17340404235 sales@biots.cn China 300 66
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Suzhou haiyu Biochem Industrial Co., LTD 512-68097639 18013585858 744942877@qq.com China 915 62
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Supplier Advantage
Jinan Guangchen Pharmaceutical Technology Co., Ltd 58
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD 58
J & K SCIENTIFIC LTD. 76
Sichuan Tongsheng Amino acids Co.,Ltd. 66
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
Suzhou haiyu Biochem Industrial Co., LTD 62
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64

View Lastest Price from Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate pictures 2026-09-11 Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
2199-51-1
 1KG 98%min 100kg WUHAN FORTUNA CHEMICAL CO., LTD
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate pictures 2026-08-25 Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
2199-51-1
 $1.60-6.60 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate pictures 2023-12-04 Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
2199-51-1
 98%+ 100kg Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Spectrum

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate(2199-51-1)1HNMR

2199-51-1(Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate)Related Search:

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ETHYL 2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLATE ETHYL 2,4-DIMETHYL-PYRROLE-3-CARBOXYLATE ETHYL 2,4-DIMETHYLPYRROLE-3-CARBOXYLIC ACID 1H-Pyrrole-3-carboxylic acid, 2,4-dimethyl-, ethyl ester Sunitinib Impurity 28 Sunitinib malate INT III Ethyl 2,4-dimethylpyrrole-3-carboxylate 98% Pyrrole-3-carboxylic acid, 2,4-dimethyl-, ethyl ester 2,4-Dimethyl-1H-pyrrole-3-carboxylic acid ethyl Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 98% 2,4-Dimethylpyrrole-3-carboxylic acid ethyl ester Ethyl 2,4-diMethyl-1H-pyr... Pyrrole-3-carboxylicacid, 2,4-diMethyl-, ethyl ester (6CI,7CI,8CI) 2,4-Dimethyl-3-(ethoxycarbonyl)-1H-pyrrole Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 2,4-Dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylatethyl-1H-pyrrole-3-carboxylic acid Ethyl2,4-Dimethylpyrrole-3-carboxylate> 4-dimethyl-1H-pyrrole-3-carboxylate Sunitinib Impurity 41 Ethyl 2,4-dimethyl-1H-pyrrol-3-carboxylate thyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 2,4-Dimethyl-3-carbethoxypyrrole 2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID ETHYL ESTER 2199-51-1 Sunitinib Intermediate Intermediate of sunitinib malate Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines Pharmaceutial intermediates 2199-51-1