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ChemicalBook >> CAS DataBase List >>Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Structure
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate structure
CAS No.
2199-51-1
Chemical Name:
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
Synonyms
Sunitinib Impurity 28;Sunitinib Impurity 41;Sunitinib malate INT III;Ethyl 2,4-diMethyl-1H-pyr...;4-dimethyl-1H-pyrrole-3-carboxylate;ETHYL 2,4-DIMETHYL-PYRROLE-3-CARBOXYLATE;Ethyl2,4-Dimethylpyrrole-3-carboxylate>2,4-Dimethyl-3-(ethoxycarbonyl)-1H-pyrrole;Ethyl 2,4-dimethyl-1H-pyrrol-3-carboxylate;thyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
CBNumber:
CB1696136
Molecular Formula:
C9H13NO2
Molecular Weight:
167.21
MDL Number:
MFCD01365811
MOL File:
2199-51-1.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:46
Product description Number Pack Size Price
Ethyl 2,4-Dimethylpyrrole-3-carboxylate >98.0%(GC) E1075 1g $43
Ethyl 2,4-Dimethylpyrrole-3-carboxylate >98.0%(GC) E1075 5g $171
2,4-Dimethyl-1H-pyrrole-3-carboxylicAcidEthylEster D477995 10g $130
2,4-Dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester 040268 10g $150
Ethyl2,4-dimethylpyrrole-3-carboxylate,≥98%(GC) ≥98%(GC) 43755 5G $161.78
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Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Properties

Melting point 122-123°C
Boiling point 162°C/11mmHg(lit.)
Density 1.1222 (rough estimate)
refractive index 1.4680 (estimate)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Soluble), Chloroform (Slightly), Methanol (Slightly)
pka 16.44±0.50(Predicted)
form Solid
color Red to Very Dark Red
λmax 258nm(EtOH)(lit.)
InChI InChI=1S/C9H13NO2/c1-4-12-9(11)8-6(2)5-10-7(8)3/h5,10H,4H2,1-3H3
InChIKey QWSFDUPEOPMXCV-UHFFFAOYSA-N
SMILES N1C=C(C)C(C(OCC)=O)=C1C
CAS DataBase Reference 2199-51-1(CAS DataBase Reference)
NIST Chemistry Reference 2,4-Dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester(2199-51-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301+H331-H315-H319-H360-H371-H373-H317-H334-H341-H350-H410
Precautionary statements  P501-P273-P272-P260-P270-P202-P201-P271-P264-P280-P284-P302+P352-P391-P337+P313-P305+P351+P338-P308+P311-P362+P364-P333+P313-P301+P310+P330-P304+P340+P311-P403+P233-P405
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39-45-22
Hazard Note  Irritant
HS Code  29337900

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical E1075 Ethyl 2,4-Dimethylpyrrole-3-carboxylate >98.0%(GC) 2199-51-1 1g $43 2025-07-31 Buy
TCI Chemical E1075 Ethyl 2,4-Dimethylpyrrole-3-carboxylate >98.0%(GC) 2199-51-1 5g $171 2025-07-31 Buy
TRC D477995 2,4-Dimethyl-1H-pyrrole-3-carboxylicAcidEthylEster 2199-51-1 10g $130 2021-12-16 Buy
Oakwood 040268 2,4-Dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester 2199-51-1 10g $150 2021-12-16 Buy
Chem-Impex 43755 Ethyl2,4-dimethylpyrrole-3-carboxylate,≥98%(GC) ≥98%(GC) 2199-51-1 5G $161.78 2021-12-16 Buy
Product number Packaging Price Buy
E1075 1g $43 Buy
E1075 5g $171 Buy
D477995 10g $130 Buy
040268 10g $150 Buy
43755 5G $161.78 Buy

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Chemical Properties,Uses,Production

Chemical Properties

White to light brown crystalline

Uses

2,4-Dimethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is used in the preparation of blue pyrrole dyes. 2,4-Dimethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is also used as an intermediate in the synthesis of receptor tyrosine kinase (RTK) inhibitors and their metabolites.

Uses

ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate is used in the preparation of blue pyrrole dyes. It is also used as an intermediate in the synt hesis of receptor tyrosine kinase (RTK) inhibitors and their metabolites.

Synthesis

3,5-Dimethylpyrrole-2,4-dicarboxylic acid 2-t-butyl ester-4-ethyl ester

86770-31-2

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

2199-51-1

Step (ii): Preparation of 2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester In a 10-liter four-necked round-bottomed flask equipped with a mechanical stirrer, thermometer casing, gas introduction tube, and air condenser, 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester (II) (1.5 kg, 5.6 mol) and isopropanol (4.5 L) were added and stirred at 25-30 °C. Concentrated hydrochloric acid (2.2 L) was added slowly through the addition funnel. After addition, the reaction mixture was warmed up to 45-50 °C and maintained at this temperature until complete cessation of gas release. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the solution was cooled to 25-30 °C and quenched in an ice-water bath. The product was separated by filtration and dried at 50 °C. A dried product of 721.3 g was obtained with 77.3% yield and >96% HPLC purity.

References

[1] Synlett, 2010, # 17, p. 2561 - 2564
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3062 - 3065
[3] Journal of the American Chemical Society,
[4] Journal of the American Chemical Society, 2009, vol. 131, p. 8578 - 8586
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 1, p. 139 - 146

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate synthesis

5442-91-1
2199-51-1
Synthesis of Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate from 4-(Ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Preparation Products And Raw materials

Raw materials

1H-Pyrrole-1,3-dicarboxylic acid, 2,4-dimethyl-, 1-(1,1-dimethylethyl) 3-ethyl ester 2-BENZYL 4-ETHYL 3,5-DIMETHYL-1H-PYRROLE-2,4-DICARBOXYLATE ETHYL 3-METHYL-4-OXOCROTONATE 4-(Ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid 3,5-Dimethylpyrrole-2,4-dicarboxylic acid 2-t-butyl ester-4-ethyl ester
Diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate Methyllithium Ethyl acetoacetate Acetonitrile Hydrochloric acid

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Preparation Products

(Z)-ethyl 5-((5-fluoro-2-oxoindolin-3-ylidene)Methyl)-2,4-diMethyl-1H-pyrrole-3-carboxylate ETHYL 2,4-DIMETHYL-5-NITRO-1H-PYRROLE-3-CARBOXYLATE 1H-Pyrrole-3-carboxylicacid,2,4-dimethyl-5-(1-oxopropyl)-,ethylester(9CI) Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Suppliers

Global( 254)Suppliers
Supplier Tel Email Country ProdList Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16513 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 880 50
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29830 58
Jinan Shengqi pharmaceutical Co,Ltd 		86+18663751872 christine@shengqipharm.com CHINA 491 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2953 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Supplier Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Shanghai Time Chemicals CO., Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
career henan chemical co 		58
Jinan Shengqi pharmaceutical Co,Ltd 		58
Jinan Finer Chemical Co., Ltd 		58
Standardpharm Co. Ltd. 		58

View Lastest Price from Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate pictures 2026-03-13 Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
2199-51-1
 US $0.00 / KG 1KG 98%min 100kg WUHAN FORTUNA CHEMICAL CO., LTD
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate pictures 2025-10-13 Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
2199-51-1
 US $1.60-6.60 / kg 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate pictures 2023-12-04 Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
2199-51-1
 US $0.00-0.00 / kg 0.1kg 98%+ 100kg Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Spectrum

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate(2199-51-1)1HNMR

2199-51-1(Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate)Related Search:

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3,4-Dimethylaniline Dimethyl carbonate RESMETHRIN Dimethyl sulfate ETHANE
Pyrrole Dimethyl ether 2,4-Dimethyl aniline Dimethyl fumarate Dacthal
2,5-Dimethylpyrrolidine Dimethyl sulfoxide Polyvinylpyrrolidone

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2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL 2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLATE ETHYL 2,4-DIMETHYL-PYRROLE-3-CARBOXYLATE ETHYL 2,4-DIMETHYLPYRROLE-3-CARBOXYLIC ACID 1H-Pyrrole-3-carboxylic acid, 2,4-dimethyl-, ethyl ester Sunitinib Impurity 28 Sunitinib malate INT III Ethyl 2,4-dimethylpyrrole-3-carboxylate 98% Pyrrole-3-carboxylic acid, 2,4-dimethyl-, ethyl ester 2,4-Dimethyl-1H-pyrrole-3-carboxylic acid ethyl Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 98% 2,4-Dimethylpyrrole-3-carboxylic acid ethyl ester Ethyl 2,4-diMethyl-1H-pyr... Pyrrole-3-carboxylicacid, 2,4-diMethyl-, ethyl ester (6CI,7CI,8CI) 2,4-Dimethyl-3-(ethoxycarbonyl)-1H-pyrrole Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 2,4-Dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylatethyl-1H-pyrrole-3-carboxylic acid Ethyl2,4-Dimethylpyrrole-3-carboxylate> 4-dimethyl-1H-pyrrole-3-carboxylate Sunitinib Impurity 41 Ethyl 2,4-dimethyl-1H-pyrrol-3-carboxylate thyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 2199-51-1 Sunitinib Intermediate Intermediate of sunitinib malate Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines Pharmaceutial intermediates 2199-51-1