Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
- CAS No.
- 2199-59-9
- Chemical Name:
- Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
- Synonyms
- Sunitinib Impurity 29;Sunitinib Impurity 38;3,5-Dimethyl-4-(ethoxycarbonyl)-;2,4-DIMETHYL-3-ETHOXYCARBONYL-5-FORMYLPYRROLE;Ethyl 2,4-dimethyl-5-formylpyrrole-3-carboxylate;ETHYL 3,5-DIMETHYL-2-FORMYLPYRROLE-4-CARBOXYLATE;Ethyl 5-ForMyl-2,4-diMethylpyrrole-3-carboxylate;Ethyl 5-Formyl-2,4-dimethyl-3-pyrrolecarboxylate;Ethyl5-Formyl-2,4-dimethyl-3-pyrrolecarboxylate>Ethyl5-formyl-2,4-dimethylpyrrole-3-carboxylate,95%
- CBNumber:
- CB6172930
- Molecular Formula:
- C10H13NO3
- Molecular Weight:
- 195.22
- MDL Number:
- MFCD00030352
- MOL File:
- 2199-59-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 164.0 to 168.0 °C |
|---|---|
| Boiling point | 358.4±42.0 °C(Predicted) |
| Density | 1.173±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 14.65±0.50(Predicted) |
| form | Solid |
| color | Beige |
| λmax | 297nm(EtOH)(lit.) |
| InChI | InChI=1S/C10H13NO3/c1-4-14-10(13)9-6(2)8(5-12)11-7(9)3/h5,11H,4H2,1-3H3 |
| InChIKey | GDISALBEIGGPER-UHFFFAOYSA-N |
| SMILES | N1C(C=O)=C(C)C(C(OCC)=O)=C1C |
| CAS DataBase Reference | 2199-59-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester(2199-59-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1051 | Ethyl 5-Formyl-2,4-dimethyl-3-pyrrolecarboxylate >98.0%(GC) | 2199-59-9 | 1g | $48 | 2026-04-30 | Buy |
| TCI Chemical | E1051 | Ethyl 5-Formyl-2,4-dimethyl-3-pyrrolecarboxylate >98.0%(GC) | 2199-59-9 | 5g | $188 | 2026-04-30 | Buy |
| Usbiological | 275906 | Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate Asreported | 2199-59-9 | 500mg | $340 | 2026-06-03 | Buy |
| Usbiological | 275906 | Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate Asreported | 2199-59-9 | 1g | $529 | 2026-06-03 | Buy |
| Usbiological | 275906 | Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate Asreported | 2199-59-9 | 2g | $726 | 2026-06-03 | Buy |
Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate Chemical Properties, Uses, Production
Chemical Properties
Brown crystals
Uses
5-ForMyl-2,4-diMethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is used as an intermediate in the synthesis of receptor tyrosine kinase (RTK) inhibitors and their metabolites.
Synthesis
2199-51-1
2199-59-9
The general procedure for the synthesis of ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate from ethyl 2,4-dimethylpyrrole-3-carboxylate was as follows: dimethylformamide (322 g) was mixed with dichloromethane (3700 mL) and cooled to 4 °C in an ice bath, followed by the slow addition of phosphorus trichloride (684 g) under stirring. Solid ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate (670 g) was added in batches over 15 min and the maximum temperature was controlled at 18 °C during the reaction. The reaction mixture was heated to a reflux state maintained for 1 h. Subsequently, the temperature was raised to 15 °C by cooling to 10 °C and rapid addition of 1.6 L of ice water. 10N hydrochloric acid (1.6L) was added with vigorous stirring and the temperature was raised to 22°C. The reaction was allowed to stand for 30 minutes to allow the two phases to separate. The two phases were allowed to separate by standing for 30 minutes, during which time the maximum temperature reached 40°C. The pH of the aqueous phase was adjusted to 12-13 with 10N potassium hydroxide (3.8L), and the temperature was maintained at 55°C during the adjustment. After adjustment, the mixture was cooled to 10°C and stirred for 1 hour. The product was collected by vacuum filtration and washed four times with water to afford ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate (778 g, 100% yield) as a yellow solid. The product was analyzed by 1H-NMR (DMSO-d6) and mass spectrometry to confirm the structure: 1H-NMR δ 1.25 (t, 3H, CH3), 2.44,2.48 (2*s, 2*3H, 2*CH3), 4.16 (q, 2H, CH2), 9.59 (s, 1H, CHO), 12.15 (br s, 1H, NH); MS m/z 195 [M+1].
References
[1] Patent: US2003/216410, 2003, A1
[2] Patent: US2003/130280, 2003, A1
[3] Patent: US2003/100555, 2003, A1
[4] Patent: US2002/32204, 2002, A1
[5] Patent: US2002/156292, 2002, A1
Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Chemtrue Bio-Tech Co.,Ltd. | 19967494293 | sales@chemtrue-bio.com | China | 303 | 58 |
| Hotechem Shanghai Co., Ltd., | 021-34621078 13120882795 | 465106944@qq.com | China | 859 | 56 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Suzhou haiyu Biochem Industrial Co., LTD | 512-68097639 18013585858 | 744942877@qq.com | China | 915 | 62 |
View Latest Price from Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-17 | Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
2199-59-9
|
1KG | 98%min | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
2199-59-9
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-04-04 | Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
2199-59-9
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
|
-
- Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
2199-59-9
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
2199-59-9
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
2199-59-9
- 98%
- Henan Aochuang Chemical Co.,Ltd.
2199-59-9 (Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate) Related Search:
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