DROXIDOPA
- CAS No.
- 23651-95-8
- Chemical Name:
- DROXIDOPA
- Synonyms
- L-threo-3,4-Dihydroxyphenylserine;l-dops;Droxidopa (JAN);SM 5688;roxidopa;DROXIDOPA;Droxydopa;l-threodops;Droxidopa>Droxidopa-13C6
- CBNumber:
- CB1699324
- Molecular Formula:
- C9H11NO5
- Molecular Weight:
- 213.19
- MDL Number:
- MFCD00799030
- MOL File:
- 23651-95-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 232-235° (dec); mp 229-232° (dec) (Ohashi) |
|---|---|
| alpha | D20 -39° (c = 1 in 1N aq HCl); D20 -42.0° (c = 1 in 1N aq HCl) |
| Boiling point | 549.8±50.0 °C(Predicted) |
| Density | 1.608±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: ≥3mg/mL |
| form | powder |
| pka | 2.09±0.24(Predicted) |
| color | white to tan |
| Merck | 14,3457 |
| Stability | Hygroscopic |
| InChI | InChI=1/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/s3 |
| InChIKey | QXWYKJLNLSIPIN-WWXSATIUNA-N |
| SMILES | [C@H](C1C=CC(O)=C(O)C=1)(O)[C@H](N)C(=O)O |&1:0,10,r| |
| CAS DataBase Reference | 23651-95-8 |
| FDA UNII | J7A92W69L7 |
| ATC code | C01CA27 |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VT9626010 | |||||||||
| HS Code | 29225090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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DROXIDOPA price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D9446 | L-DOPS ≥98% (HPLC) | 23651-95-8 | 5mg | $162 | 2026-04-30 | Buy |
| Sigma-Aldrich | D9446 | L-DOPS ≥98% (HPLC) | 23651-95-8 | 25mg | $642 | 2026-04-30 | Buy |
| TCI Chemical | D4235 | Droxidopa >98.0%(HPLC)(T) | 23651-95-8 | 50mg | $129 | 2026-04-30 | Buy |
| TCI Chemical | D4235 | Droxidopa >98.0%(HPLC)(T) | 23651-95-8 | 200mg | $333 | 2026-04-30 | Buy |
| Cayman Chemical | 23779 | Droxidopa ≥95% | 23651-95-8 | 1mg | $36 | 2026-04-30 | Buy |
DROXIDOPA Chemical Properties,Uses,Production
Description
Droxidopa is a synthetic amino acid precursor of (-)-norepinephrine which is absorbed from the gut and metabolized to norepinephrine. In Parkinsonian patients, droxidopa added to existing levodopa/decarboxylase inhibitor therapy produces significant improvements in retropulsion, dysarthria and muscular rigidity refractory to other treatments; however, tremor was unaffected.
Description
Droxidopa (L-DOPS) is a synthetic precursor and prodrug of the neurotransmitter norepinephrine. It is transformed into norepinephrine through the action of DOPA decarboxylase. L-DOPS increases norepinephrine levels in the rat heart following intraperitoneal administration and in the brain following intracerebroventricular administration at doses of 125 and 100 μg/animal, respectively. It increases arterial pressure and mesenteric arterial resistance in rats with ligated portal vein or biliary ducts when used at doses of 25-50 mg/kg. L-DOPS crosses the blood brain barrier, however, its effects can be blocked by the peripherally-restricted DOPA decarboxylase inhibitor carbidopa , indicating that the mechanism is peripheral. Formulations containing droxidopa are used in the treatment of neurogenic orthostatic hypotension.
Chemical Properties
Off-White Solid
Originator
Sumitomo (Japan)
Uses
The L-threo-form Droxidopa. A synthetic amino acid precursor of Norepinephrine (N674500). Antiparkinsonian.
Uses
Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).
Uses
L-DOPS has been administered for clinical trial studies in mice with amyloid pathology.
Definition
ChEBI: A serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension
brand name
DOPS
General Description
L-DOPS, also called L-threo 3,4-Dihydroxyphenylserine or droxidopa is a catecholamine. L-DOPS has many clinical advantages and may be useful for treating norepinephrine deficiency. It is used for treating neurogenic orthostatic hypotension and improves norepinephrine levels. L-DOPS mediates reduction of amyloid plaques and could have a therapeutic potential for treating amyloid pathology.
Biochem/physiol Actions
L-DOPS is a norepinephrine precursor in vivo.
References
[1] J BARTHOLINI. The stereoisomers of 3,4-dihydroxyphenylserine as precursors of norepinephrine.[J]. Journal of Pharmacology and Experimental Therapeutics, 1975, 193 2: 523-532.
[2] MAR COLL. Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats[J]. Hepatology, 2012, 56 5: 1849-1860. DOI: 10.1002/hep.25845
[3] HORACIO KAUFMANN Jose A P Lucy Norcliffe Kaufmann. Droxidopa in neurogenic orthostatic hypotension.[J]. Expert Review of Cardiovascular Therapy, 2015, 13 8: 875-891. DOI: 10.1586/14779072.2015.1057504
DROXIDOPA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Tomums Life Science Co., Ltd. | 020-31155029 18902330969 | sales@tomums.cn | China | 4688 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4484 | 50 | |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
View Lastest Price from DROXIDOPA manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-12 | DROXIDOPA
23651-95-8
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
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2026-09-02 | DROXIDOPA
23651-95-8
|
$6.00-8.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
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2026-08-07 | DROXIDOPA
23651-95-8
|
$1.00-4.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd |
