4-Ethoxyphenylboronic acid
- CAS No.
- 22237-13-4
- Chemical Name:
- 4-Ethoxyphenylboronic acid
- Synonyms
- AKOS BRN-0070;4-Boronophenetole;RARECHEM AH PB 0138;4-Ethoxyphenylboroni;4-Etoxyphenylboronic acid;P-ETHOXYPHENYLBORONIC ACID;4-ETHOXYPHENYLBORONIC ACID;(4-ethoxyphenyl)boronicaci;4-ETHOXYBENZENEBORONIC ACID;4-Ethoxybenzeneboronicacid,96%
- CBNumber:
- CB1724741
- Molecular Formula:
- C8H11BO3
- Molecular Weight:
- 165.98
- MDL Number:
- MFCD00674028
- MOL File:
- 22237-13-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 121-128 °C(lit.) |
|---|---|
| Boiling point | 317.6±44.0 °C(Predicted) |
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 8.98±0.10(Predicted) |
| form | solid |
| color | White to Light yellow |
| BRN | 3530408 |
| InChI | InChI=1S/C8H11BO3/c1-2-12-8-5-3-7(4-6-8)9(10)11/h3-6,10-11H,2H2,1H3 |
| InChIKey | WRQNDLDUNQMTCL-UHFFFAOYSA-N |
| SMILES | B(C1=CC=C(OCC)C=C1)(O)O |
| CAS DataBase Reference | 22237-13-4(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
4-Ethoxyphenylboronic acid price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 455539 | 4-Ethoxyphenylboronic acid | 22237-13-4 | 1g | $32.4 | 2023-01-07 | Buy |
| Sigma-Aldrich | 455539 | 4-Ethoxyphenylboronic acid | 22237-13-4 | 10g | $106 | 2023-01-07 | Buy |
| TCI Chemical | E0725 | 4-Ethoxyphenylboronic Acid (contains varying amounts of Anhydride) | 22237-13-4 | 1g | $20 | 2026-04-30 | Buy |
| TCI Chemical | E0725 | 4-Ethoxyphenylboronic Acid (contains varying amounts of Anhydride) | 22237-13-4 | 5g | $59 | 2026-04-30 | Buy |
| Biosynth | FE139723 | (4-Ethoxyphenyl)boronic acid | 22237-13-4 | 100g | $900 | 2026-06-04 | Buy |
4-Ethoxyphenylboronic acid Chemical Properties, Uses, Production
Chemical Properties
White crystalline powder
Uses
4-Methoxybenzeneboronic acid is used for suzuki reaction.
Application
Reactant involved in Suzuki cross coupling reactions
Reactant involved in the synthesis of biologically active molecules including:
Novel modulators of survival motor neuron protein for treatment of spinal muscular atrophy
Amino-trimethoxyphenyl-aryl thiazoles for use as microtubule inhibitors and antitumor agents
Bicyclic hydroxyphenyl methanone derivatives for use as hydroxysteroid dehydrogenase inhibitors
Dual immunosuppressive and anti-inflammatory agents
Antiproliferatives via Suzuki cross-coupling / amination reactions
Synthesis
A hexane solution of butyllithium (30 mL, 1.58 M, 47 mmol) was added dropwise to a THF solution (50 mL) of 2-bromo-,-trifluorotoluene (9.79 g, 43.5 mmol) at -78 C. The aryllithium was then transferred to a THF solution of B(OEt)3 (30 mL, 176 mmol) by cannulae. After stirring at this temperature for 3 hours, the resulting aryl lithium was transferred via cannula to a THF solution (100 mL) of triethyl borate (B(OEt)3, 30 mL, 176 mmol) (aryl lithium may be unstable at higher temperatures. We recommend making the transfer as soon as possible). Warm the reaction mixture to room temperature and stir overnight. Hydrochloric acid (2M, 80 mL) was added and the mixture was extracted with ethyl acetate. The combined organic layers were dried with anhydrous sodium sulfate and then evaporated under vacuum. The desired boric acid was dissolved in hot toluene and separated from the toluene-insoluble residue. The combined toluene solutions were evaporated and the remaining solid was recrystallized from toluene to give 4-ethoxyphenylboronic acid in 6.02 g, 73% yield. Yield 16%.
4-Ethoxyphenylboronic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Xinshengjiahe Technology Development Co., Ltd. | 022-83719186 13212251377 | 18522618860@163.com | China | 82 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Scientia Pharmaceutical Technology Co., Ltd. | 21-21-54301573 13917723525 | sales@scientiapharm.com | China | 260 | 62 |
View Latest Price from 4-Ethoxyphenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | 4-ETHOXYPHENYLBORONIC ACID
22237-13-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 4-ETHOXYPHENYLBORONIC ACID
22237-13-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 4-ETHOXYPHENYLBORONIC ACID
22237-13-4
|
$1.00 | 1kg | 98% | 1000kg | Career Henan Chemical Co |
-
- 4-ETHOXYPHENYLBORONIC ACID
22237-13-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-ETHOXYPHENYLBORONIC ACID
22237-13-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-ETHOXYPHENYLBORONIC ACID
22237-13-4
- $1.00
- 98%
- Career Henan Chemical Co
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