2,3-Difluoro-4-ethoxybenzeneboronic acid
- CAS No.
- 212386-71-5
- Chemical Name:
- 2,3-Difluoro-4-ethoxybenzeneboronic acid
- Synonyms
- 4-Ethoxy-2,3-difluorophenyl;4-Ethoxy-2,3-difluorphenylboronic acid;4-Ethoxy-2,3-difluorophenylboronic acid;2,3-Difluoro-4-ethoxyphenylboronic acid;2,3-Difluror-4-ethoxyphenylboronic acid;(4-ethoxy-2,3-difluorophenyl)boronicaci;2,3-Difluoro-4-ethoxybenzeneboronic acid;4-Ethoxy-2,3-difluorobenzeneboronic Acid;2,3-Difluoro-4-ethoxybenzeneboronicacid98%;B-(4-Ethoxy-2,3-difluorophenyl)boronic acid
- CBNumber:
- CB7958102
- Molecular Formula:
- C8H9BF2O3
- Molecular Weight:
- 201.96
- MDL Number:
- MFCD09258743
- MOL File:
- 212386-71-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 151-154 |
|---|---|
| Boiling point | 316.0±52.0 °C(Predicted) |
| Density | 1.29 |
| vapor pressure | 0.002Pa at 25℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| form | Solid |
| pka | 7.69±0.58(Predicted) |
| color | White to Almost white |
| Water Solubility | 145mg/L at 20℃ |
| InChI | InChI=1S/C8H9BF2O3/c1-2-14-6-4-3-5(9(12)13)7(10)8(6)11/h3-4,12-13H,2H2,1H3 |
| InChIKey | OBKSFBWOZSQGGC-UHFFFAOYSA-N |
| SMILES | B(C1=CC=C(OCC)C(F)=C1F)(O)O |
| LogP | 2.3 at 23℃ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2931900090 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2,3-Difluoro-4-ethoxybenzeneboronic acid price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1192 | 4-Ethoxy-2,3-difluorophenylboronic Acid (contains varying amounts of Anhydride) | 212386-71-5 | 1g | $21 | 2026-04-30 | Buy |
| TCI Chemical | E1192 | 4-Ethoxy-2,3-difluorophenylboronic Acid (contains varying amounts of Anhydride) | 212386-71-5 | 5g | $71 | 2026-04-30 | Buy |
| Apolloscientific | PC7277 | 2,3-Difluoro-4-ethoxybenzeneboronic acid >99% | 212386-71-5 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC7277 | 2,3-Difluoro-4-ethoxybenzeneboronic acid >99% | 212386-71-5 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC7277 | 2,3-Difluoro-4-ethoxybenzeneboronic acid >99% | 212386-71-5 | 5g | $29 | 2026-06-04 | Buy |
2,3-Difluoro-4-ethoxybenzeneboronic acid Chemical Properties, Uses, Production
Chemical Properties
off-white powder
Uses
suzuki reaction
Flammability and Explosibility
Not classified
Synthesis
156573-09-0
121-43-7
212386-71-5
General procedure for the synthesis of 2,3-difluoro-4-bromophenyl ethyl ether and trimethyl borate as raw materials for the synthesis of 2,3-difluoro-4-ethoxyphenylboronic acid: intermediate compound T-2 (129.5 g) obtained in Example 1 was dissolved in dry tetrahydrofuran (Dry THF, 500 ml) and the resulting solution was cooled to -70 °C. Under nitrogen protection, n-butyllithium (n-BuLi, 500 ml) was slowly added dropwise and the reaction was stirred at -70 °C for 2 hours. Subsequently, a dry tetrahydrofuran (Dry THF) solution of trimethyl borate (129.5 g) was added slowly dropwise at the same temperature. Upon completion of the reaction, the reaction solution was warmed to room temperature and stirring was continued for 16 hours. The reaction mixture was acidified by adding 2N hydrochloric acid (200 ml) to the reaction mixture and subsequently extracted with toluene. The organic layer was washed sequentially with water and saturated aqueous sodium chloride solution and then dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give a light brown solid. Purification by recrystallization (heptane: toluene = 4:1, v/v) resulted in colorless crystals T-20 (117.2 g, yield: 71%).
References
[1] Patent: EP2484658, 2012, A1. Location in patent: Page/Page column 42
[2] Patent: JP5663957, 2015, B2. Location in patent: Paragraph 0137-0138; 0140
[3] Patent: US2009/278089, 2009, A1. Location in patent: Page/Page column 13
2,3-Difluoro-4-ethoxybenzeneboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 2,3-Difluoro-4-ethoxybenzeneboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-12-29 | 2,3-Difluoro-4-ethoxybenzeneboronic acid
212386-71-5
|
1kg | 98% | Changzhou waston chemical technology Co.,Ltd | |||
 |
2025-04-04 | 2,3-Difluoro-4-ethoxybenzeneboronic acid
212386-71-5
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2023-05-04 | 2,3-Difluoro-4-ethoxybenzeneboronic acid cas
212386-71-5
|
$40.00-48.00 | 1KG | 99% | 200tons | Guangzhou Sunton Biotechnology Co., Ltd. |
-
- 2,3-Difluoro-4-ethoxybenzeneboronic acid
212386-71-5
- $0.00
- 98%
- Changzhou waston chemical technology Co.,Ltd
-
- 2,3-Difluoro-4-ethoxybenzeneboronic acid
212386-71-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2,3-Difluoro-4-ethoxybenzeneboronic acid cas
212386-71-5
- $40.00-48.00
- 99%
- Guangzhou Sunton Biotechnology Co., Ltd.
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