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6-Chloro-1-benzothiophene-2-carboxylic acid

6-Chloro-1-benzothiophene-2-carboxylic acid Structure
6-Chloro-1-benzothiophene-2-carboxylic acid structure
CAS No.
26018-73-5
Chemical Name:
6-Chloro-1-benzothiophene-2-carboxylic acid
Synonyms
6-Chlorobenzo[b]thiophene-2-carboxylic acid;2-Carboxy-6-chlorobenzo[b]thiophene;6-chlorobenzothiophene-2-carboxylic acid;6-chloro-2-benzothiophenecarboxylic acid;6-Chlorobenzo[b]thiophen-2-carboxylic acid;6-Chloro-1-benzothiophene-2-carboxylic acid;Benzo[b]thiophene-2-carboxylic acid, 6-chloro-;2-Carboxy-6-chlorobenzo[b]thiophene, 2-Carboxy-6-chloro-1-benzothiophene, 2-Carboxy-6-chlorothianaphthene
CBNumber:
CB1730610
Molecular Formula:
C9H5ClO2S
Molecular Weight:
212.65
MDL Number:
MFCD07377059
MOL File:
26018-73-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:50:04
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6-Chloro-1-benzothiophene-2-carboxylic acid Properties

Melting point 271-274
Boiling point 408.6±25.0 °C(Predicted)
Density 1.546±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
form Solid
pka 3.34±0.30(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C9H5ClO2S/c10-6-2-1-5-3-8(9(11)12)13-7(5)4-6/h1-4H,(H,11,12)
InChIKey AVAGKGZNBMZOLD-UHFFFAOYSA-N
SMILES C12=CC(Cl)=CC=C1C=C(C(O)=O)S2

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xi
HazardClass  IRRITANT
HS Code  2934999090

6-Chloro-1-benzothiophene-2-carboxylic acid price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR14043 6-Chlorobenzo[b]thiophene-2-carboxylic acid ≥95% 26018-73-5 500mg $21 2026-06-04 Buy
Apolloscientific OR14043 6-Chlorobenzo[b]thiophene-2-carboxylic acid ≥95% 26018-73-5 1g $24 2026-06-04 Buy
Matrix Scientific 047320 6-Chloro-1-benzothiophene-2-carboxylic acid 26018-73-5 1.00g $33 2026-05-18 Buy
Matrix Scientific 047320 6-Chloro-1-benzothiophene-2-carboxylic acid 26018-73-5 5.00g $134 2026-05-18 Buy
Matrix Scientific 047320 6-Chloro-1-benzothiophene-2-carboxylic acid 26018-73-5 25.00g $400 2026-05-18 Buy
Product number Packaging Price Buy
OR14043 500mg $21 Buy
OR14043 1g $24 Buy
047320 1.00g $33 Buy
047320 5.00g $134 Buy
047320 25.00g $400 Buy

6-Chloro-1-benzothiophene-2-carboxylic acid Chemical Properties, Uses, Production

Synthesis

Methyl 6-chlorobenzo[b]thiophene-2-carboxylate

104795-85-9

6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID

26018-73-5

1. To a solution of DMF (7 mL) containing 600 mg (3.23 mmol) of 4-chloro-2-nitrobenzaldehyde was added 559 mg (4.04 mmol) of potassium carbonate and 294 μL (3.23 mmol) of methyl thioglycolate sequentially at 0°C. The reaction mixture was stirred for 30 min. at 0°C followed by continued stirring at room temperature for 24 hours. The reaction mixture was stirred at 0°C for 30 minutes, followed by continued stirring at room temperature for 24 hours. Upon completion of the reaction, the mixture was poured into ice water, the precipitate was collected by filtration, and the precipitate was dissolved in ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate and concentrated to give 630 mg (86% yield) of methyl 6-chlorobenzo[b]thiophene-2-carboxylate as a white solid.1H NMR (CDCl3, 300 MHz): δ 3.95 (s, 3H), 7.88 (dd, J = 8.6, 1.9 Hz, 1H), 7.79 (d, J = 8.6 Hz, 1H), 7.85 (d, J = 8.6 Hz, 1H), 7.79 (d, J = 8.6 Hz, 1H). 7.85 (d, J = 1.9 Hz, 1H), 8.02 (s, 1H). 2. 6.95 mL of aqueous 1N LiOH was added to a 630 mg (2.78 mmol) solution of methyl 6-chlorobenzo[b]thiophene-2-carboxylate in THF (5 mL), and the reaction mixture was stirred for 4 h at room temperature. Upon completion of the reaction, the pH was adjusted to 2-3 with 1N HCl and subsequently extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated to give 579 mg (98% yield) of 6-chlorobenzo[b]thiophene-2-carboxylic acid as a white solid.MS (ISP): 211.0 (M-H)-. 3. 139 mg (0.65 mmol) of 6-chlorobenzo[b]thiophene-2-carboxylic acid was converted to 52 mg (0.14 mmol) of (6-chlorobenzo[b]thiophen-2-ylmethyl)-[2-(3,4-dichlorophenyl)ethyl]amine by reference to the method of Example S3 (Steps a to b), the product was a colorless liquid.MS (ISP): 370.0 (M+H )+.

References

[1] Patent: US2007/185113, 2007, A1. Location in patent: Page/Page column 13
[2] Patent: WO2016/100184, 2016, A1. Location in patent: Paragraph 00270
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 20, p. 4793 - 4807

6-Chloro-1-benzothiophene-2-carboxylic acid synthesis

104795-85-9
26018-73-5
Synthesis of 6-Chloro-1-benzothiophene-2-carboxylic acid from Methyl 6-chlorobenzo[b]thiophene-2-carboxylate

6-Chloro-1-benzothiophene-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Ethyl Thioglycolate Ethanol N,N-Dimethylformamide 4-Chloro-2-fluorobenzaldehyde Potassium carbonate
Lithium hydroxide monohydrate Tetrahydrofuran Ethyl acetate Ethyl 6-chloro-1-benzothiophene-2-carboxylate Methyl 6-chlorobenzo[b]thiophene-2-carboxylate

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Preparation Products

6-Chloro-1-benzothiophene-2-carboxylic acid Suppliers

Global Suppliers ( 78)
Supplier Tel Email Country ProdList Advantage
ShldaTech. Co., Ltd. 18014808303 3674571109@qq.com China 33 58
Sichuan Fanzhijian Biomedical Technology Co., Ltd 15281070185 2865097598@qq.com China 60 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16306 64
Xi’an chemsoar Medical Technology Co., ltd 029-86538357 China 234 57
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
SynAsst Chemical. 021-60343070 China 12731 55
Supplier Advantage
ShldaTech. Co., Ltd. 58
Sichuan Fanzhijian Biomedical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Adamas Reagent, Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
Xi’an chemsoar Medical Technology Co., ltd 57
9ding chemical ( Shanghai) Limited 56
SynAsst Chemical. 55

View Latest Price from 6-Chloro-1-benzothiophene-2-carboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID pictures 2026-07-08 6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID
26018-73-5
 1kg 98% 10000kgS Shaanxi Dideu New Materials Co. Ltd
6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID pictures 2020-02-17 6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID
26018-73-5
 $7.00 1KG 99% 100KG Career Henan Chemical Co

6-Chloro-1-benzothiophene-2-carboxylic acid Spectrum

6-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID(26018-73-5)1HNMR

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6-chloro-2-benzothiophenecarboxylic acid 6-chlorobenzothiophene-2-carboxylic acid 2-Carboxy-6-chlorobenzo[b]thiophene 2-Carboxy-6-chlorobenzo[b]thiophene, 2-Carboxy-6-chloro-1-benzothiophene, 2-Carboxy-6-chlorothianaphthene Benzo[b]thiophene-2-carboxylic acid, 6-chloro- 6-Chlorobenzo[b]thiophen-2-carboxylic acid 6-Chlorobenzo[b]thiophene-2-carboxylic acid 6-Chloro-1-benzothiophene-2-carboxylic acid 26018-73-5